3-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]-N-dodecylpropanamide | 1018999-00-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]-N-dodecylpropanamide
• CAS: 1018999-00-2
• 化学式: C₄₇H₉₅N₅O₃
• 分子量: 778.303
• InChiKey: QXQYMNUQLAYDHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  55
• 可旋转键数：
  45
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  103
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]-N-dodecylpropanamide 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 3,3'-((2-((3-(dodecylamino)-3-oxopropyl)(2-oxoethyl)amino)ethyl)azanediyl)bis(N-dodecylpropanamide)
  参考文献：
  名称：

  WO2008/42973

  摘要：

  公开号：
• 作为产物：
  描述：

  N-十二烷基丙烯酰胺 、 乙二胺 在 硼酸 作用下， 以 水 为溶剂， 反应 96.0h， 生成 N-dodecyl-3-[2-[[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]propanamide 、 3-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]-N-dodecylpropanamide 、 3-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]-N-dodecylpropanamide
  参考文献：
  名称：

  WO2008/42973

  摘要：

  公开号：

文献信息

• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• US9006487B2
  申请人：——

  公开号：US9006487B2

  公开（公告）日：2015-04-14
• WO2008/42973
  申请人：——

  公开号：——

  公开（公告）日：——