1-amino-dodecan-1-ol | 40899-01-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-amino-dodecan-1-ol
• 英文别名: 1-Aminododecan-1-OL
• CAS: 40899-01-2
• 化学式: C₁₂H₂₇NO
• 分子量: 201.352
• InChiKey: KAFWCKOMHCHXFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  十二醛 在 ammonium hydroxide 作用下， 生成 1-amino-dodecan-1-ol
  参考文献：
  名称：

  Structure and chemistry of the aldehyde ammonias. 1-Amino-1-alkanols, 2,4,6-trialkyl-1,3,5-hexahydrotriazines, and N,N-dialkylidene-1,1-diaminoalkanes

  摘要：

  DOI：

  10.1021/jo00959a010

文献信息

• POLYMER-CARBOHYDRATE CONJUGATES FOR DRUG DELIVERY TECHNOLOGY
  申请人：Wu Nian

  公开号：US20150157721A1

  公开（公告）日：2015-06-11

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  该发明包括化合物、制备方法和使用方法。这些化合物可能具有线性或环状的骨架，以及三个或四个附加的功能基团：一个或两个疏水化合物，包括固醇或“脂溶性”维生素，一个或两个亲水性聚合物，以及一个或两个碳水化合物。公开了一组具有中心骨架和三个附加功能基团的聚合物-碳水化合物共轭物，其中一个疏水性化合物不含类固醇酸。该共轭物可能以脂肪酸作为主要疏水载体，一个亲水性聚合物和一个碳水化合物。特定的功能基团可以根据在制备药物、化妆品、营养保健品等方面的具体应用而选择。共轭物的典型偶联反应可能涉及一种或多种或组合或串联的烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化化学过程。还可以选择各种连接剂连接骨架和功能基团之间，以修改载体或中心骨架以进行偶联反应并优化共轭物的性能。
• [EN] POLYMER-CYCLODEXTRIN-LIPID CONJUGATES<br/>[FR] CONJUGUÉS POLYMÈRE-CYCLODEXTRINE-LIPIDE
  申请人：WU NIAN

  公开号：WO2016209732A1

  公开（公告）日：2016-12-29

  The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three or four appended functional groups are disclosed, wherein one of the hydrophilic components is cyclodextrin. The compounds may have a backbone with three or four appended functional groups: one or two lipophilic compounds including sterols or "fat soluble" vitamins or fatty acids, one or two hydrophilic polymer and one cyclodextrin. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the center backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  该发明涵盖了化合物、制备方法和使用方法。公开了一组具有中心骨架和三个或四个附加功能基团的聚合物-环糊精-脂质共轭物，其中一个亲水成分是环糊精。这些化合物可能具有一个带有三个或四个附加功能基团的骨架：一个或两个疏水化合物，包括甾醇或“脂溶性”维生素或脂肪酸，一个或两个亲水性聚合物和一个环糊精。特定的功能基团可以针对制备药物、化妆品、营养保健品等特定应用进行选择。共轭物的典型偶联反应可能涉及一种或多种或组合或串联的烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化化学过程。还可以选择各种连接剂连接中心骨架和功能基团，以修改载体或中心骨架用于偶联反应并优化共轭物的性能。
• [EN] METHOD FOR PRODUCING AN AMINE<br/>[FR] PROCÉDÉ DE PRODUCTION D'UNE AMINE
  申请人：RHODIA OPERATIONS

  公开号：WO2020098937A1

  公开（公告）日：2020-05-22

  The invention relates to a method for producing an amine by reacting an alcohol, aldehyde and/or ketone with hydrogen and nitrogen-containing compound in the presence of a silver and/or ruthenium promoted cobalt catalyst. The nitrogen-containing compound is selected from ammonia, primary amines and secondary amines.

  这项发明涉及一种通过在存在银和/或钌促进的钴催化剂的情况下，将醇、醛和/或酮与氢气和含氮化合物反应来生产胺的方法。所述含氮化合物选自氨、一级胺和二级胺。
• POLYMER-CARBOHYDRATE-LIPID CONJUGATES
  申请人：Wu Nian

  公开号：US20120202890A1

  公开（公告）日：2012-08-09

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.

  该发明包括化合物、制备方法和使用方法。这些化合物可能具有一个主干和三个附加的功能基团：一个脂质基团、一个亲水性聚合物基团和一个碳水化合物基团。特定的功能基团可以根据在制备药物、化妆品、营养保健品等方面的具体应用而选择。还可以选择各种连接剂来优化主干和功能基团之间的性能。
• THERMAL ENERGY STORAGE AND TEMPERATURE STABILIZATION PHASE CHANGE MATERIALS COMPRISING ALKANOLAMIDES AND DIESTERS AND METHODS FOR MAKING AND USING THEM
  申请人：Entropy Solutions Inc.

  公开号：US20170044414A1

  公开（公告）日：2017-02-16

  This invention generally relates to thermoregulation and temperature stabilization, thermal protection and insulation, and nucleating agents. In particular, in alternative embodiments, provided are organic phase change materials comprising diesters and alkanolamides. In alternative embodiments, provided are Phase Change Material (PCMs) compositions comprising diesters and alkanolamides, and methods for making and using them. In alternative embodiments, the Phase Change Material (PCMs) compositions are used for thermal energy management, including energy storage and/or temperature stabilization, in various applications such as building, automotive, packaging, garment and footwear, textiles, fabrics, synthetic fibers, foods, microcapsules and other energy storage systems.

  这项发明通常涉及热调节和温度稳定、热保护和隔热以及成核剂。特别是，在替代实施方案中，提供了包括二酯和脂肪醇胺的有机相变材料。在替代实施方案中，提供了包括二酯和脂肪醇胺的相变材料（PCM）组合物，并提供了制备和使用它们的方法。在替代实施方案中，相变材料（PCM）组合物用于热能管理，包括在建筑、汽车、包装、服装和鞋类、纺织品、织物、合成纤维、食品、微胶囊和其他能量存储系统等各种应用中的能量存储和/或温度稳定。