4,4′‑(phenylmethylene)bis(3‑phenyl‑1‑p‑tolyl‑1H‑pyrazol‑5‑ol) | 39084-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4′‑(phenylmethylene)bis(3‑phenyl‑1‑p‑tolyl‑1H‑pyrazol‑5‑ol)
• 英文别名: 2,5,2',5'-tetraphenyl-1,2,1',2'-tetrahydro-4,4'-phenylmethanediyl-bis-pyrazol-3-one；Benzyliden-bis-/diphenylpyrazolinon)
• CAS: 39084-10-1
• 化学式: C₃₇H₂₈N₄O₂
• 分子量: 560.655
• InChiKey: BIABULGKZKFEBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.98
• 重原子数：
  43.0
• 可旋转键数：
  7.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  76.1
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  4,4′‑(phenylmethylene)bis(3‑phenyl‑1‑p‑tolyl‑1H‑pyrazol‑5‑ol) 、 乙烷,三氯氟- 以 甲醇 为溶剂， 生成 2-(4-Methylphenyl)-4,6,8,10,12-pentakis-phenyl-2,4,5,11,12-pentazatricyclo[7.3.0.03,7]dodeca-1(9),3(7),5,10-tetraene
  参考文献：
  名称：

  Ahluwalia, V. K.; Sharma, Pooja; Goyal, Bindu, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 11, p. 1059 - 1061

  摘要：

  DOI：
• 作为产物：
  描述：

  4-benzylidene-4,5-dihydro-1,3-diphenyl-1H-pyrazol-5-one 在 乙酸铵 、 phenacylpyridinium salt 、 苯甲醛 作用下， 以 溶剂黄146 、 甲苯 为溶剂， 反应 2.0h， 以55%的产率得到4,4′‑(phenylmethylene)bis(3‑phenyl‑1‑p‑tolyl‑1H‑pyrazol‑5‑ol)
  参考文献：
  名称：

  Pyridinium N-Ylides and (Arylmethylene)azol-5-ones. Reaction Cascade Leading to an Unusual Spiroisoxazolinone Ring

  摘要：

  The reaction of a series of (arylmethylene)azol-5-ones with phenacylpyridinium salt 3 in glacial acetic acid/ammonium acetate mixture gives different results depending on the starting azolone. The isoxazol-5-ones 1 give the unusual spirans 6 in a reaction cascade involving Michael- and retro-Michael reactions, C-alkylation, aldol addition, and diastereospecific cyclization. The reaction performed with oxazol-5-ones 11 has shown that a literature re po rt has to he corrected since no oxazolopyridines 12 hut rather arylideneimidazol-5-ones 13 are produced. In the case of pyrazolin-5-ones 14, the unavoidable formation of bis-adducts 15 always prevents any other type of reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00921-2

文献信息

• Silica-bonded DABCO hydrogen sulfate ((SB-DABCO)HSO4): a new dual-interphase catalyst for the diversity-oriented pseudo-five-component synthesis of bis(pyrazolyl)methanes and novel 4-[bis(pyrazolyl)methane]phenylmethylene-bis(indole)s
  作者：Mohsen Shekouhy、Reza Kordnezhadian、Ali Khalafi-Nezhad

  DOI：10.1007/s13738-018-1424-x

  日期：2018.10

  and was successfully applied for the diversity-oriented synthesis of bis(pyrazolyl)methanes via a one-pot pseudo-five-component condensation reaction. This approach provides a versatile range of available substrates and high diversity of desired products. Moreover, ((SB-DABCO)HSO4) was successfully applied for the synthesis of some novel [bis(pyrazolyl)methane]-bis(indole)s as more complex molecules

  硅胶键合的正丙基-4-氮杂-1-氮杂双环[ 2.2.2 ]辛烷硫酸氢盐（（SB-DABCO）HSO 4）被制备为新型的相间双催化剂，并成功地用于多元定向合成双（吡唑基）甲烷通过一锅假五组分缩合反应。这种方法提供了多种可用基材，并提供了所需产品的高度多样性。此外，（（SB-DABCO）HSO 4）作为更复杂的分子已成功地用于一些新型[双（吡唑基）甲烷]-双（吲哚）的合成。
• DHAL P. N.; ACHARY T. E.; NAYAK A., J. INDIAN CHEM. SOC. <JICS-AH>, 1975, 52, NO 12, 1196-1199
  作者：DHAL P. N.、 ACHARY T. E.、 NAYAK A.

  DOI：——

  日期：——