5-(bromomethyl)-2-nitrophenol | 26386-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(bromomethyl)-2-nitrophenol
• 英文别名: Phenol, 5-(bromomethyl)-2-nitro-
• CAS: 26386-82-3
• 化学式: C₇H₆BrNO₃
• 分子量: 232.034
• InChiKey: KNYZFJUGKIWQJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(bromomethyl)-2-nitrophenol 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 生成 (3-羟基-4-硝基-苯基)-乙酸
  参考文献：
  名称：

  Structure−Activity Studies for a Novel Series of N-(Arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines Possessing Dual 5-HT Uptake Inhibiting and α₂-Antagonistic Activities

  摘要：

  In search of an alpha(2)-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the alpha(2)-receptor (K-i = 6.71 nM) and the 5-HT uptake site (20.6 nM). A series of tertiary amine analogs of 3 were synthesized and assayed for their affinity at both the alpha(2)-receptor and the 5-HT uptake site. The structure-activity relationship reveals that a variety of structural modifications to the arylethyl fragment are possible with retention of this dual activity. On the tetralin portion, 5-OMe substitution and the (R) stereochemistry at C-l are optimal with alternate substitutions producing compounds retaining high affinity for the alpha(2)-receptor but lacking affinity for the 5-HT uptake site. Data for several rigidified 5-O-alkyl analogs suggests that the favored orientation of the oxygen lone pairs may be away from the g-position of the tetralin.

  DOI：

  10.1021/jm960723m
• 作为产物：
  描述：

  3-羟基-4-硝基苯甲酸 在 吡啶硼烷 、 硼酸三甲酯 、 四溴化碳 、 三氟化硼乙醚 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 5-(bromomethyl)-2-nitrophenol
  参考文献：
  名称：

  Diphenylpolyene-cholesterol conjugates as fluorescent probes for microheterogeneous media

  摘要：

  Extrinsically conjugated fluorescent diphenylpolyene cholesterol derivatives are synthesized and spectroscopic investigations in homogeneous and aqueous micellar solutions are described. The emission of these cholesterol conjugates reveals characteristic intra-molecular charge transfer (ICT) behaviour in homogeneous solvents with a mono-exponential decay. Spectroscopic evidence in micellar aqueous solutions reveals a bi-exponential decay. This indicates the presence of two preferred locations of the cholesterol conjugated diphenylpolyenes sites of lower polarity and interfacial sites. The sensitivity of these fluorophores was utilized to determine the critical micelle concentrations. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2014.02.013

文献信息

• [EN] SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF<br/>[FR] SYNTHÈSE DE COMPOSÉS ET DE DÉRIVÉS HYDROXYSTILBÈNE SUBSTITUÉS ET UTILISATIONS DE CEUX-CI
  申请人：KYNAN DUKE IP LLC

  公开号：WO2021127743A1

  公开（公告）日：2021-07-01

  The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

  本公开涉及替代羟基芪类化合物及其衍生物，具体为2-取代羟基芪类化合物及其衍生物，这些化合物的合成以及它们在治疗中的应用。
• Selective Detection of the Carbohydrate-Bound State of Concanvalin A at the Single Molecule Level
  作者：James J. La Clair

  DOI：10.1021/ja964366g

  日期：1997.8.1
• US5958673A
  申请人：——

  公开号：US5958673A

  公开（公告）日：1999-09-28
• US6140041A
  申请人：——

  公开号：US6140041A

  公开（公告）日：2000-10-31
• [EN] FLUORESCENT DYE<br/>[FR] COLORANT FLUORESCENT
  申请人：NOVARTIS AG

  公开号：WO1999038919A1

  公开（公告）日：1999-08-05

  (EN) Fluorescent dyes possess reactive linkers for conjugating to nucleic acids, carbohydrates and peptides. The conjugates fluoresce in the visible and UV spectrum and have an excellent solvochromatic response as compared to other fluorescence or chromatic labels. The conjugates are stable but also have medium sensitive. The fluorescent dyes have little triplet state formation and are not photoreactive, making them an excellent substance for biological investigations. Uses for the dyes include protein labeling, DNA labeling, single molecule spectroscopy and fluorescence. A synthesis of the dyes is disclosed. Methods of use include the detection of carbohydrate-protein interactions.(FR) L'invention concerne des colorants fluorescents possédant des segments de liaison réactifs pour se conjuguer aux acides nucléiques, hydrates de carbone et peptides. Les conjugués sont fluorescents dans le spectre visible et ultraviolet et possèdent une excellente réponse solvochromatique comparés à d'autres marqueurs fluorescents ou chromatiques. Les conjugués sont stables mais possèdent également un milieu sensible. Les colorants fluorescents forment peu de triplets et ne sont pas photoréactifs, ce qui en fait une excellente substance pour les recherches biologiques. On peut utiliser les colorants pour le marquage de protéines, le marquage d'ADN, la spectroscopie et la fluorescence de molécule unique. L'invention concerne également une synthèse des colorants. Les procédés selon l'invention comprennent la détection d'interactions hydrates de carbone-protéines.