4-chloro-N-hexyl-1,8-naphthalimide | 93881-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-chloro-N-hexyl-1,8-naphthalimide
• 英文别名: 6-chloro-2-hexyl-1H-benzo[de]isoquinoline-1,3(2H)-dione；6-chloro-2-hexyl-benz[de]isoquinoline-1,3-dione；6-Chlor-2-hexyl-benz[de]isochinolin-1,3-dion；6-Chloro-2-hexylbenzo[de]isoquinoline-1,3-dione
• CAS: 93881-60-8
• 化学式: C₁₈H₁₈ClNO₂
• 分子量: 315.799
• InChiKey: OCVDMWKCRHHRQZ-UHFFFAOYSA-N

物化性质

• 熔点：
  71-73 °C(Solv: isopropanol (67-63-0))
• 沸点：
  469.9±28.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-N-hexyl-1,8-naphthalimide 在 一水合肼 作用下， 以 二甲基亚砜 为溶剂， 反应 4.0h， 以43%的产率得到4-hydrazino-N-hexyl-1,8-naphthalimide
  参考文献：
  名称：

  Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I

  摘要：

  Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections. Enzyme hydrolysis releases 2-hexyl-6-hydrazino-1H-benzo[de]isoquinoline-1,3(2H)-dione, which couples with piperonal to form insoluble fluorescent hydrazone, precipitating on the enzyme locations and marking them. The fluorescent technique reveals precisely the enzymes locations at the lack of background noise in a single incubation step. It avoids most of the drawbacks of the previously proposed fluorescent histochemical techniques and can be valuable for the in situ studies of these enzymes in norm and pathology. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.036
• 作为产物：
  描述：

  4-氯-1,8-萘二甲酸酐 以 苯甲腈 为溶剂， 反应 26.0h， 生成 4-chloro-N-hexyl-1,8-naphthalimide
  参考文献：
  名称：

  与先前的报道相反 ，4-取代的1,8-萘二甲酰亚胺的杂环对亲核攻击不是惰性的†

  摘要：

  据报道具有抗亲核攻击性的N-芳基-4-氯-1,8-萘二甲酰亚胺的杂环在室温下与伯胺亲核试剂反应，得到4-氯-N-烷基-1,8-萘二甲酰亚胺。该反应在萘二甲酰亚胺中是一级的。哈米特图是线性的（R 2 0.996），具有大的正斜率（+3.0），与活化的配合物中氮上的大量负电荷形成一致。

  DOI：

  10.1039/c3ob40639c

文献信息

• Novel polymers, compositions comprising them, processes therefor and use thereof
  申请人：Luukas Timo

  公开号：US20050220732A1

  公开（公告）日：2005-10-06

  Disclosed herein are novel block polymers comprising at least one monomer with an optical effect, and cosmetic compositions comprising the polymers, such as nail varnish compositions, foundation compositions, and anti-ageing compositions. Also disclosed herein are a cosmetic treatment process comprising applying to a keratin material the cosmetic composition as disclosed herein, and the use of these polymers as tensioning agents.

  本文揭示了包含至少一种具有光学效应的单体的新型块聚合物，以及包含这些聚合物的化妆品组合物，如指甲油组合物、粉底组合物和抗衰老组合物。本文还揭示了一种化妆品处理过程，包括将本文所述的化妆品组合物应用于角蛋白材料，并将这些聚合物用作紧肤剂。
• Composition comprising a monomeric compound with an optical effect, process using said composition, monomeric compound, polymer comprising the same and use thereof
  申请人：Luukas Timo

  公开号：US20070189987A1

  公开（公告）日：2007-08-16

  The invention relates to a cosmetic or pharmaceutical composition containing, in a physiologically-acceptable medium, at least one polymer comprising at least one novel monomeric compound having optical effect properties. The invention also relates to a cosmetic method of making up or caring for keratin materials, such as the skin belonging to the body or face, lips, nails, eyelashes, eyebrows and/or hair, consisting in applying one such cosmetic composition to said materials. The invention further relates to novel monomeric compounds having formula (I) and optical properties, the polymers comprising same and the uses thereof in a composition in order to provide said composition with optical effects, e.g. fluorescence or optical brightening.

  该发明涉及一种化妆品或药用组合物，包含至少一种聚合物，该聚合物包含至少一种具有光学效应性能的新型单体化合物，在生理可接受的介质中。该发明还涉及一种化妆方法，用于化妆或护理角质素材料，如属于身体或面部的皮肤、嘴唇、指甲、睫毛、眉毛和/或头发，包括将这种化妆品组合物应用于这些材料。该发明还涉及具有式（I）和光学性能的新型单体化合物，包含这些单体化合物的聚合物以及在组合物中使用它们以赋予所述组合物光学效果，例如荧光或光学增白效果。
• Composition Comprising a Monomer Compound Exhibiting an Optical Property, Method Making Use of Said Composition, a Monomer Compound and a Polymer Containing Said Monomer Compound and the Use Thereof
  申请人：Luukas Timo

  公开号：US20080226581A1

  公开（公告）日：2008-09-18

  The invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one type of polymer containing at least one type of novel monomer compound exhibiting optical properties. Said invention also relates to a cosmetic method for making up or treating keratinous materials, in particular a body or face skin, lips, nails, eyebrows, eyelashes and/or hairs, including the application of said cosmetic composition to said materials. Novel monomer compounds exhibiting optical properties, polymers containing said compounds and the use thereof in a composition in order to transfer the optical properties thereto, in particular fluorescent or optical brightener properties are also disclosed.

  该发明涉及一种化妆品或药用组合物，包括在生理上可接受的介质中，至少一种含有至少一种表现出光学特性的新型单体化合物的聚合物。该发明还涉及一种化妆方法，用于化妆或处理角质材料，特别是身体或面部皮肤、嘴唇、指甲、眉毛、睫毛和/或头发，包括将该化妆品组合物应用于所述材料。还公开了表现出光学特性的新型单体化合物、含有该化合物的聚合物以及将其用于组合物中以转移光学特性，特别是荧光或光亮剂特性。
• MOLECULES AND METHODS FOR FLUORESCENCE MICROSCOPY
  申请人：Hartsel C. Scott

  公开号：US20060205760A1

  公开（公告）日：2006-09-14

  The present invention provides molecules and methods for fluorescent microscopy and visualization of biomolecules, such as cholesterol. In a preferred embodiment, the present invention provides a compound having the structure: wherein R 1 and R 2 are selected from the group consisting of H, C n H 2n+1 , (CH 2 ) m NH 2 , (CH 2 ) m NH—SO 2 —R′, and CH 2 CH 2 OCH 2 CH 2 NH 2 wherein n has a value between 4 and 18, wherein m has a value between 2 and 8, and wherein R′ is selected from the group consisting of CH 3 , C 6 H 4 , C 6 H 4 CH 3 , C 6 H 4 CO 2 H an its cyclic imide, C 6 H 4 Br, anthraquinon-2-yl, and 5-formyl-2-furyl, 2-carboxyphenyl.

  本发明提供了用于荧光显微镜和生物分子可视化的分子和方法，例如胆固醇。在一种优选实施例中，本发明提供了一种具有以下结构的化合物：其中R1和R2选自H，CnH2n+1，(CH2)mNH2，(CH2)mNH—SO2—R′和CH2CH2OCH2CH2NH2的群组，其中n的值在4到18之间，m的值在2到8之间，而R′选自CH3，C6H4，C6H4CH3，C6H4CO2H及其环戊二酰亚胺，C6H4Br，蒽醌-2-基和5-甲酰基-2-呋喃基，2-羧基苯基。
• Nouveaux polymères séquencés, compositions les comprenant, procédés et utilisation
  申请人：L'OREAL

  公开号：EP1580204A1

  公开（公告）日：2005-09-28

  La présente demande concerne de nouveaux polymères séquencés comprenant au moins un monomère à effet optique, les compositions cosmétiques les comprenant, notamment les compositions de vernis à ongles, de fond de teint et les compositions anti-age. L'invention concerne également un procédé de traitement cosmétique employant ladite composition, et l'utilisation de ces polymères comme tenseurs.

  本申请涉及包含至少一种光学效应单体的新型嵌段聚合物，以及包含这些单体的化妆品组合物，特别是指甲油组合物、粉底组合物和抗衰老组合物。 本发明还涉及使用上述组合物的化妆品处理方法，以及将这些聚合物用作张力剂。