3-乙氧基-2-甲基-1-丙烯 | 24309-28-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-乙氧基-2-甲基-1-丙烯
• 英文名称: 3-ethoxy-2-methyl-1-propene
• 英文别名: 2-methyl-2-propenyl ethyl ether；ether d'ethyle et de methallyle；3-Ethoxy-2-methyl-1-propen；3-ethoxy-2-methylpropene；ethyl methallyl ether；3-ethoxy-2-methyl-propene；3-ethoxy-2-methylprop-1-ene
• CAS: 24309-28-2
• 化学式: C₆H₁₂O
• 分子量: 100.161
• InChiKey: CVEARUDSOVGFAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

反应信息

• 作为反应物：
  描述：

  3-乙氧基-2-甲基-1-丙烯 在 二(氰基苯)二氯化钯 作用下， 反应 72.0h， 以6%的产率得到1-乙氧基-2-甲基丙-1-烯
  参考文献：
  名称：

  Pd(II)催化剂存在下叠氮化物与不饱和醚之间的氮烯转移反应

  摘要：

  在 PdCl2(PhCN)2 的催化下，叠氮甲酸酯与烯丙基醚反应生成 1-烷氧基-1-(烷氧基羰基亚氨基)烷烃。通过叠氮化物与相应乙烯基醚的非催化反应，几乎定量地形成了相同的亚胺。发现催化反应的速率在烯丙基醚和叠氮化物中分别为一级。从烯丙基醚形成亚胺的难易程度取决于叠氮化物的性质，按 N3SO2Me>N3CO2Me>N3Ph 的顺序递减。基于这些结果，提出了催化反应最可能的机理。

  DOI：

  10.1246/bcsj.61.931
• 作为产物：
  描述：

  3-氯-2-甲基丙烯 在 氢氧化钾 作用下， 生成 3-乙氧基-2-甲基-1-丙烯
  参考文献：
  名称：

  Tamele et al., Industrial and Engineering Chemistry, 1941, vol. 33, p. 119

  摘要：

  DOI：

文献信息

• Tandem Hydroformylation/Fischer Indole Synthesis:  A Novel and Convenient Approach to Indoles from Olefins
  作者：Petra Köhling、Axel M. Schmidt、Peter Eilbracht

  DOI：10.1021/ol0350184

  日期：2003.9.1

  [reaction: see text] A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.

  [反应：见正文]描述了一种通过串联加氢甲酰化/费歇尔吲哚合成从烯烃和芳基肼开始的新颖的一锅合成。如果使用未取代的苯肼，则该串联过程直接导致3-取代的吲哚，而如果使用对或邻取代的芳基肼，则直接导致3,5-分别为3,7-二取代的吲哚。
• ORGANIC COMPOUNDS AND THEIR USES
  申请人：Brandl Trixl

  公开号：US20100204159A1

  公开（公告）日：2010-08-12

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

  本申请描述了对人类疾病的治疗、预防和/或改善有用的有机化合物。
• A NEW REACTION OF AZIDOFORMATE WITH UNSATURATED ETHERS CATALYZED BY DICHLORO-BIS(BENZONITRILE)PALLADIUM
  作者：Toshihiko Migita、Nobuhiro Saitoh、Hisao Iizuka、Chikataka Ogyu、Masanori Kosugi、Setsuko Nakaido

  DOI：10.1246/cl.1982.1015

  日期：1982.7.5

  In the presence of dichloro-bis(benzonitrile)palladium, azidoformate reacts with various unsaturated ethers to give 1-alkoxy-1-carboalkoxyiminoalkanes. Reaction with 1-methyl-2-propenyl ether was accompaied by methyl migration, giving 1-alkoxy-1-carboalkoxyimino-2-methylpropane.

  在二氯双（苄腈）钯存在下，叠氮甲酸酯与各种不饱和醚反应生成 1-烷氧基-1-碳烷氧基亚氨基烷烃。与1-甲基-2-丙烯基醚的反应伴随着甲基迁移，得到1-烷氧基-1-碳烷氧基亚氨基-2-甲基丙烷。
• Metalated allylic ethers as homoenolate anion equivalents
  作者：D. A. Evans、G. C. Andrews、B. Buckwalter

  DOI：10.1021/ja00824a039

  日期：1974.8

  a Reference 6 . Assigned to conform to predicted values, Calculated from uNu) values for 3,4, and 6 by the relation 1 = 3 + 3[(6 4)/4]. * Calculated from ax(%) values by the relation 1 = 6 + 6[(3 4)/4]. e Calculated from 2 = 3 + 3[(5 4)/4]. fCalculated from 2 = 5 + 5[(3 4)/4]. 0 Average values for R = Me and i-Pr from ref 5, plus R = Et from ref 10. This work. Average of values for acyclic trialkylhydrazyls

  a 参考文献 6。分配以符合预测值，根据 3,4 和 6 的 uNu) 值通过关系 1 = 3 + 3[(6 4)/4] 计算。* 根据 ax(%) 值通过关系 1 = 6 + 6[(3 4)/4] 计算。e 由 2 = 3 + 3[(5 4)/4] 计算。f 由 2 = 5 + 5[(3 4)/4] 计算。0 参考文献 5 中 R = Me 和 i-Pr 的平均值，加上参考文献 10 中的 R = Et。这项工作。无环三烷基肼的平均值，Le.，R1 = Me 和 i-Pr，其中 RZ = R3 = Me。我这项工作。R = i-Pr。j 系列 3、4、5 和 6 中的线性插值。 R = Me 和 PhCHn 的平均值，
• TWO -PHOTON UPCONVERTING DYES AND APPLICATIONS
  申请人：——

  公开号：US20030022105A1

  公开（公告）日：2003-01-30

  The present invention is directed to styryl dyes having the formula: 1 wherein D is an electron donating group; Q is an electron acceptor selected from the group consisting of electron acceptors having the formulae: 2 W is an electron accepting group, R 3 is selected from the group consisting of substituted or unsubstituted alkyl or substituted or unsubstituted aryl moieties, n is an integer from 0 to 4, A, B, and C are substituents of their rings and are each independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, sulfoalkyl, carboxyalkyl, and hydrogen, and Y is a counterion and compositions thereof. The dyes and compositions exhibit superior two-photon absorption cross-sections and are useful in two-photon pumped cavity lasing, two-photon pumped up-conversion lasing, optical power limiting, optical power stabilization, optical signal reshaping, and infrared beam detection and indication. The present invention is also directed to a multiphasic nanostructured composite including a glass having pores, an optically active coating material on the pore surface, such as a sytryl dye of the present invention, and a polymeric material in the pores. Optionally, the polymeric material can have a second optically active material dispersed therein. These composites are useful in producing multifunctional optical materials, such as broadly tunable lasers. The present invention is also directed to a method for killing cells and viruses. The method includes providing proximate to the cells or viruses a photosensitizer, such as a porphyrin, and a two-photon upconverting dye, such as a styryl dye of the present invention. The dye is then exposed to light in the presence of oxygen under conditions effective to produce a cytotoxic effect on the cells or viruses. These methods are especially useful to kill cells and viruses in biological materials, such as in photodynamic therapy of tumors and cancers or blood purification protocols. In another aspect, the present invention discloses media and methods for recording data. A three-dimensional matrix including a plurality of dye molecules, such a styryl dye molecule of the present invention, is provided. A first volume element in the matrix is exposed to actinic radiation for a duration and at an intensity effective to alter detectably a fraction between 0.3 and 0.7 of the dye molecules contained therein. The detectably altered dye molecules are substantially uniformly dispersed in the first volume element. The data storage methods and media of the present invention have approximately 10 12 volume elements per square centimeter, and each of the volume elements can store a single bit, digital information of approximately 8 bits, or analog information. The data storage methods and media of the present invention are particularly useful for storing or archiving a series of two-dimensional black and white or color images, such as frames of a movie. Methods for reading data stored in the data storage media of the present invention using confocal microscopy are also disclosed.

  本发明涉及具有以下公式的苯乙烯染料：1其中D为电子供体基团；Q为从具有以下公式的电子受体组成的组中选择的电子受体：2W为电子受体基团；R3从取代或未取代的烷基或取代或未取代的芳基基团组成的组中选择；n为0到4的整数；A、B和C是它们的环的取代基，且每个独立地从烷基、烷氧基、羟基烷基、磺基烷基、羧基烷基和氢中选择；Y为一个计数离子。该染料和组合物表现出优越的双光子吸收截面，并可用于双光子泵浦腔激光、双光子泵浦上转换激光、光功率限制、光功率稳定、光信号重塑和红外光束检测和指示。本发明还涉及一种多相纳米结构复合材料，包括具有孔道的玻璃、孔表面上的光学活性涂层材料，例如本发明的苯乙烯染料，以及孔内的聚合物材料。可选地，聚合物材料中可以分散有第二种光学活性材料。这些复合材料可用于生产多功能光学材料，例如广泛可调谐激光器。本发明还涉及一种杀死细胞和病毒的方法。该方法包括在靠近细胞或病毒的位置提供光敏剂，例如卟啉，以及本发明的苯乙烯染料等双光子上转换染料。然后，在氧气存在的条件下，将染料暴露于光下，以对细胞或病毒产生细胞毒作用。这些方法特别适用于在生物材料中杀死肿瘤和癌症或血液净化协议等细胞和病毒。在另一方面，本发明揭示了用于记录数据的介质和方法。提供了一个三维矩阵，其中包括多个染料分子，例如本发明的苯乙烯染料分子。将矩阵中的第一个体积元素暴露于光化学辐射下，以在0.3和0.7之间改变其中所含的染料分子的分数。经过可检测的改变的染料分子在第一个体积元素中被均匀分散。本发明的数据存储方法和介质每平方厘米有大约1012个体积元素，每个体积元素可以存储一个比特、大约8个比特的数字信息或模拟信息。本发明的数据存储方法和介质特别适用于存储或归档一系列二维黑白或彩色图像，例如电影帧。还揭示了使用共聚焦显微镜读取本发明的数据存储介质中存储的数据的方法。