N-(1-氧代庚基)甘氨酸乙酯 | 574010-47-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(1-氧代庚基)甘氨酸乙酯
• 英文名称: Ethyl 2-(heptanoylamino)acetate
• CAS: 574010-47-2
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.293
• InChiKey: NOUDHEXRRCCQLU-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于氯仿、DCM、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(1-氧代庚基)甘氨酸乙酯 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以98%的产率得到N-庚酰甘氨酸
  参考文献：
  名称：

  Tetramic Acids as Scaffolds: Synthesis, Tautomeric and Antibacterial Behaviour

  摘要：

  报道了四咪酸在环氮上有各种取代基的高效合成途径、它们在溶液中的互变行为及其抗菌活性。

  DOI：

  10.1055/s-0029-1217745
• 作为产物：
  描述：

  庚醛 、 2-胺基乙酸乙酯 在 叔丁基过氧化氢 、 copper(l) iodide 、 silver(I) iodate 、 calcium carbonate 作用下， 以 水 、 乙腈 为溶剂， 反应 6.0h， 以39%的产率得到N-(1-氧代庚基)甘氨酸乙酯
  参考文献：
  名称：

  THE PREPARATION OF AMIDES BY COPPER-MEDIATED OXIDATIVE COUPLING OF ALDEHYDES AND AMINE HYDROCHLORIDE SALTS

  摘要：

  DOI：

  10.15227/orgsyn.088.0014

文献信息

• Highly efficient and recyclable copper based ionic liquid catalysts for amide synthesis
  作者：Poonam Rani、Rajendra Srivastava

  DOI：10.1039/c6nj01711h

  日期：——

  Copper based ionic liquids have been successfully prepared for the synthesis of primary, secondary and tertiary amides under mild reaction conditions.

  铜基离子液体已成功制备用于在温和反应条件下合成伯、仲和叔酰胺。
• Modulation of Bacterial Quorum Sensing With Synthetic Ligands
  申请人：Blackwell Helen E.

  公开号：US20110212860A1

  公开（公告）日：2011-09-01

  The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
• Tetramic Acids as Scaffolds: Synthesis, Tautomeric and Antibacterial Behaviour
  作者：Mark Moloney、Yong-Chul Jeong

  DOI：10.1055/s-0029-1217745

  日期：2009.9

  Efficient synthetic routes for tetramic acids variously substituted on the ring nitrogen, their tautomeric behaviour in solution and their antibiotic activity are reported.

  报道了四咪酸在环氮上有各种取代基的高效合成途径、它们在溶液中的互变行为及其抗菌活性。
• THE PREPARATION OF AMIDES BY COPPER-MEDIATED OXIDATIVE COUPLING OF ALDEHYDES AND AMINE HYDROCHLORIDE SALTS
  作者：Giguère-Bisson, Maxime、Yoo, Woo-Jin、Li, Chao-Jun

  DOI：10.15227/orgsyn.088.0014

  日期：——