benzylammonium perchlorate | 18720-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzylammonium perchlorate
• 英文别名: Benzylammonium perchlorate；benzylazanium;perchlorate
• CAS: 18720-46-2
• 化学式: C₇H₉N*ClHO₄
• 分子量: 207.614
• InChiKey: BSLSAYVLBLAJDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.98
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  97.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  苄基丙酮 、 benzylammonium perchlorate 在 三正丁基氢锡 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以88%的产率得到N-苄基-4-苯基-2-丁胺
  参考文献：
  名称：

  Suwa, Toshihiro; Sugiyama, Erika; Shibata, Ikuya, Synlett, 2000, # 4, p. 556 - 558

  摘要：

  DOI：
• 作为产物：
  描述：

  异硫氰酸苯甲酯 在 高氯酸 作用下， 以 水 为溶剂， 生成 benzylammonium perchlorate
  参考文献：
  名称：

  Joseph, V. Bernadette; Satchell, Derek P. N.; Satchell, Rosemary S., Journal of the Chemical Society. Perkin transactions II, 1992, # 3, p. 339 - 342

  摘要：

  DOI：
• 作为试剂：
  描述：

  在 benzylammonium perchlorate 作用下， 以 二甲基亚砜 为溶剂， 生成 2,4,6-三硝基甲苯 、 苄胺
  参考文献：
  名称：

  Brooke, David N.; Crampton, Michael R., Journal of the Chemical Society. Perkin transactions II, 1982, p. 231 - 238

  摘要：

  DOI：

文献信息

• Cation complexing properties of synthetic macrocyclic polyether-diester ligands containing the pyridine subcyclic unit
  作者：J. S. Bradshaw、G. E. Maas、J. D. Lamb、R. M. Izatt、J. J. Christensen

  DOI：10.1021/ja00522a004

  日期：1980.1

  Ten new macrocyclic polyether-diester compounds containing a pyridine subcyclic unit substituted in the 4 position with chloro or methoxy groups have been prepared. These compounds along with their unsubstituted pyridine analogues form strong complexes with alkylammonium and some metal cations. Complexation with alkylammonium and potassium cations was accompanied by significant chemical-shift changes

  已经制备了 10 种新的大环聚醚二酯化合物，其含有在 4 位被氯或甲氧基取代的吡啶亚环单元。这些化合物及其未取代的吡啶类似物与烷基铵和一些金属阳离子形成强配合物。与烷基铵和钾阳离子的络合伴随着 /sup 1/H NMR 光谱中的显着化学位移变化。烷基铵配合物解离的相对活化自由能 (..delta..G/sup 不等于/) 由它们的温度依赖性/sup 1/H NMR 光谱确定。甲氧基取代配体与所有研究的烷基铵离子的配合物具有更大的 ..delta..G/sup 不等于/比氯取代的配体的那些更大。地层常数以及 ..delta..H 和 T..delta.. S 值通过量热技术测定 Na/sup +/、K/sup +/、Rb/sup +/、Ag/sup +/、NH/sub 4//sup +/ 和 Ba/sup 的反应2 +/ 具有包含吡啶和 4-氯吡啶亚环基团的 18 个环成员的配体。碱金属阳离子和这些配体之间形成的配合物几乎与
• Substituent effects upon rates of deamination and base strengths of substituted N-tritylamines
  作者：Moisés Canle L.、Ibrahim Demirtas、Howard Maskill

  DOI：10.1039/b104916j

  日期：——

  Substituted N-tritylamines undergo deamination in aqueous acidic solution containing organic cosolvents, and follow a pseudo first-order specific acid-catalysis rate law (kobs = k0 + kH[H3O+]); the products are the corresponding trityl alcohols in equilibrium with the trityl carbenium ions, and ammonium ions. The change from 4,4′-dimethoxy- to 4,4′,4″-trimethoxy-tritylamine increases reactivity by a factor of about 30 in both k0 and kH, but N-alkyl and N-aryl groups have much greater effects (ca. 106 for both k0 and kH for 4,4′-dimethoxytritylamine) which are largely independent of the nature of the N-alkyl and N-aryl groups. The anions of the catalytic strong acids (perchlorate, chloride, bromide, and nitrate) have only small effects as also does the concentration of acetonitrile as cosolvent; ethanoic acid as cosolvent is mildly rate-enhancing. Substituents in the aniline residue of N-(4,4′-dimethoxytrityl)anilines have virtually no effect upon either k0 or kH (ρ = 0 for both). The results are interpreted by a mechanism involving a pre-equilibrium heterolysis of the (substituted) tritylammonium ion to give an ion–molecule pair which may undergo diffusional or acid-catalysed dissociation before the (substituted) trityl cation undergoes equilibrium nucleophilic capture by water. Base strengths of some substituted N-tritylamines have been measured; the substituted N-trityl group causes all amines (aliphatic and aromatic) to be comparably strongly basic (pKBH+ca. 9).

  替代的N-三苯基胺在含有有机共溶剂的酸性水溶液中发生脱氨反应，并遵循伪一级的特定酸催化速率定律（kobs = k0 + kH[H3O+]); 产生的产物是相应的三苯基醇，与三苯基阳离子和铵离子处于平衡状态。从4,4′-二甲氧基到4,4′,4″-三甲氧基三苯基胺的变化使反应性增加了大约30倍，在k0和kH中都是如此，但N-烷基和N-芳基取代基对反应性的影响更大（对于4,4′-二甲氧基三苯基胺，k0和kH的影响约为106），且这些影响在很大程度上独立于N-烷基和N-芳基取代基的性质。催化强酸的阴离子（高氯酸盐、氯离子、溴离子和硝酸盐）对反应的影响很小，乙腈作为共溶剂的浓度也没有显著影响；乙酸作为共溶剂略微增强了反应速率。在N-(4,4′-二甲氧基三苯基)苯胺的苯胺残基上的取代基对k0或kH几乎没有影响（ρ = 0）。这些结果通过一种机制进行了解释，该机制涉及（替代的）三苯基铵离子的前平衡异裂，形成一个离子-分子对，该对可能在（替代的）三苯基阳离子通过水进行平衡亲核捕获之前，发生扩散性或酸催化解离。一些替代的N-三苯基胺的碱性已被测量；替代的N-三苯基基团使所有胺（包括脂肪族和芳香族）具有相似的强碱性（pKBH+约为9）。
• Polypeptides modified by carbonates of polyalkylene oxide polymers
  申请人：NOVO NORDISK A/S

  公开号：EP0893439A1

  公开（公告）日：1999-01-27

  Poly(ethyhlene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

  本发明公开了聚乙二醇-N-琥珀酰亚胺碳酸盐及其制备方法。聚乙二醇（PEG）被转化为其 N-琥珀酰亚胺碳酸盐衍生物。这种形式的聚合物很容易与水缓冲液中蛋白质的氨基发生反应。经修饰的蛋白质通过稳定、耐水解的氨基甲酸乙酯连接，将 PEG 链接枝到多肽骨架上。
• Proton-ionizable crown compounds. 1. Synthesis, complexation properties, and structural studies of macrocyclic polyether-diester ligands containing a triazole subcyclic unit
  作者：Jerald S. Bradshaw、David A. Chamberlin、Paul E. Harrison、Bruce E. Wilson、Giuseppi Arena、N. Kent Dalley、John D. Lamb、Reed M. Izatt、Frederick G. Morin、David M. Grant

  DOI：10.1021/jo00217a010

  日期：1985.8
• Reduction and reductive coupling of imines by Sm(II)-based reagents
  作者：Myeongseob Kim、Brian W Knettle、Anders Dahlén、Göran Hilmersson、Robert A Flowers

  DOI：10.1016/j.tet.2003.06.004

  日期：2003.12

  The reductive coupling of aldimines and ketimines by a series of Sm(II)-based reagents (SmI2, SmI2-HMPA, SmBr2, SmN[Si(CH3)(3)](2)}(2), and SmI2/triethylamine/water) were examined. In general, aldimines and ketimines were efficiently reduced or coupled using reductants that are more powerful than SmI2, and the use of SmN[Si(CH3)(3)](2)}(2) led to higher diastereoselectivities in reductive coupling reactions. Surprisingly, only the combination of SMI2/triethylamine/water was capable of reducing and coupling para-substituted benzaldimines and coupling ketimines. (C) 2003 Elsevier Ltd. All rights reserved.