十二烷基丁酸酯 | 3724-61-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十二烷基丁酸酯
• 英文名称: butyric acid dodecyl ester
• 英文别名: Buttersaeure-dodecylester；Dodecyl butyrate；dodecyl butanoate
• CAS: 3724-61-6
• 化学式: C₁₆H₃₂O₂
• 分子量: 256.429
• InChiKey: JEPXJYKYHMEESP-UHFFFAOYSA-N

物化性质

• 熔点：
  -36°C (estimate)
• 沸点：
  299.67°C (estimate)
• 密度：
  0.8561 (estimate)
• LogP：
  7.09
• 物理描述：
  Liquid; Slightly fruity light aroma
• 溶解度：
  Insoluble in water; soluble in non-polar solvents
• 折光率：
  1.433-1.438
• 保留指数：
  1761;1763;1765;1767;1768;1771;1768;1773

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  十二烷基丁酸酯 、 ((6-bromohexyl)oxy)dimethylsilane 在 BrF(F₃s)₂ borane 作用下， 以 甲苯 为溶剂， 以96 %的产率得到6-Bromohexoxy-(1-dodecoxybutoxy)-dimethylsilane
  参考文献：
  名称：

  [EN] IONIZABLE CATIONIC LIPIDS INCORPORATING SILICON
  [FR] LIPIDES CATIONIQUES IONISABLES COMPRENANT DU SILICIUM

  摘要：

  The invention relates to a novel ionizable cationic lipid family incorporating silicon, which belongs to the trademark LipexSil™ 1st generation lipids wherein at least one of the two side chains contains silyl acetal linker. Lipids containing silyl acetal linker(s) so far are unprecedented in the art and are effective as ionizable cationic lipids in the formulation of empty or loaded lipid nanoparticles (LNPs). The novel linkers according to the invention are designed by means of borane catalysts [WO 2022/129966]. The invention describes the synthesis of the lipids of formula (I), formation and characterization of nanoparticles and biological experiments demonstrating that the lipid nanoparticles prepared with these novel lipids can efficiently deliver their cargo (e.g. RNA, DNA, mRNA, siRNA, pDNA, circular DNA, small biologically active molecules) into the cells.

  公开号：

  WO2024023174A2
• 作为产物：
  描述：

  十二烷醇 、 丁酸丁酯 在 tungsten(VI) oxide 作用下， 生成 十二烷基丁酸酯
  参考文献：
  名称：

  Mastagli; Francois, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959, vol. 249, p. 134

  摘要：

  DOI：

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Direct Conversion of Trimethylsilyl and Tetrahydropyranyl Ethers into Esters with Acid Chlorides in the Presence of Montmorillonite K-10
  作者：Barahman Movassagh、Kobra Atrak

  DOI：10.1081/scc-120026313

  日期：2003.12

  Abstract A simple method is described for an efficient conversion of variety of trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers into their corresponding esters with acid chlorides in the presence of montmorillonite K-10.

  摘要 描述了一种在蒙脱石 K-10 存在下将各种三甲基甲硅烷基 (TMS) 和四氢吡喃基 (THP) 醚有效转化为相应的酰氯酯的简单方法。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Lewis acid catalyst composition
  申请人：——

  公开号：US20040242411A1

  公开（公告）日：2004-12-02

  A Lewis acid catalyst composition comprising a specific mixed medium and a Lewis acid catalyst, wherein the Lewis acid catalyst is at least one compound selected from the group consisting of compounds respectively represented by the following formulae (1) and (2): [(R f 1 SO 2 )(R f 2 SO 2 )N] n M  (1), and [(R f 1 SO 2 )(R f 2 SO 2 )(R f 3 SO 2 )C] n M  (2). A method for continuously performing a reaction which proceeds in the presence of the above-mentioned Lewis acid catalyst by using a specific mixed medium and the above-mentioned Lewis acid catalyst. A novel Lewis acid catalyst.

  一种Lewis酸催化剂组合物，包括特定混合介质和Lewis酸催化剂，其中Lewis酸催化剂是从以下式(1)和(2)所代表的化合物组成的化合物中至少选择一种：[(Rf1SO2)(Rf2SO2)N]nM  (1)，以及[(Rf1SO2)(Rf2SO2)(Rf3SO2)C]nM  (2)。一种使用特定混合介质和上述Lewis酸催化剂连续进行反应的方法。一种新型Lewis酸催化剂。
• LIPID CONTAINING FORMULATIONS
  申请人：Manoharan Muthiah

  公开号：US20090023673A1

  公开（公告）日：2009-01-22

  Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

  本文介绍了用于管理基于核酸的治疗的组合物和方法，例如关联复合物，如脂质体和脂质复合物。

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