6-tert-butyl-5-indanol | 1623-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 6-tert-butyl-5-indanol
• 英文别名: 6-tert-butyl-indan-5-ol；6-tert.-Butylindanol-(5)；6-t-Butyl-5-indanol；6-tert-butyl-2,3-dihydro-1H-inden-5-ol
• CAS: 1623-09-2
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: CJQCYICTQKBKLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-tert-butyl-5-indanol 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 生成 6-tert-butyl-2,3-dihydro-1H-indene-5-thiol
  参考文献：
  名称：

  4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme

  摘要：

  5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S-1, S-2, S-1', and S-2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S-1' and S-2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00332-7
• 作为产物：
  描述：

  5-茚醇 、 叔丁醇 在 磷酸 作用下， 生成 6-tert-butyl-5-indanol
  参考文献：
  名称：

  4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme

  摘要：

  5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S-1, S-2, S-1', and S-2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S-1' and S-2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00332-7

文献信息

• Catalyst components for the polymerization of olefins
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP2803678A1

  公开（公告）日：2014-11-19

  A solid catalyst component for the polymerization of olefins comprising Mg, Ti, Cl and at least an electron donor compound which is the reaction product obtained by bringing into contact a Mg compound and a Ti compound having at least a Ti-halogen bond with an electron donor selected from specific diphenol derivatives.

  一种用于烯烃聚合的固体催化剂组分，包括Mg、Ti、Cl和至少一种电子供体化合物，该化合物是通过将Mg化合物和至少含有一种Ti-卤素键的Ti化合物与选自特定二酚衍生物的电子供体接触而获得的反应产物。
• HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
  申请人：Olesen Preben Houlberg

  公开号：US20100041657A1

  公开（公告）日：2010-02-18

  The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

  本发明涉及公式I的化合物，其中R5，R6和R7中至少有一个是SR12，S（O）R12或S（O）2R12基团，其中R12是C1-6卤代烷基基团，可作为化学解偶联剂。本发明的化合物在治疗，包括预防肥胖症，糖尿病以及与之相关的许多疾病或病况方面非常有用。
• CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS
  申请人：BASELL POLIOLEFINE ITALIA S.R.L.

  公开号：US20160115261A1

  公开（公告）日：2016-04-28

  A solid catalyst component for the polymerization of olefins comprising Mg, Ti, Cl and at least an electron donor compound which is the reaction product obtained by bringing into contact a Mg compound and a Ti compound having at least a Ti-halogen bond with an electron donor selected from specific diphenol derivatives.

  用于烯烃聚合的固体催化剂组分，包括Mg、Ti、Cl和至少一种电子供体化合物，该电子供体化合物是通过将Mg化合物和至少具有Ti-卤素键的Ti化合物与特定的二苯酚衍生物中选择的电子供体接触而获得的反应产物组成的。
• WO2006/120178
  申请人：——

  公开号：——

  公开（公告）日：——
• Mannich base synthesis of bisphenols
  申请人：UNION CARBIDE CORP

  公开号：US02839586A1

  公开（公告）日：1958-06-17