6-tert-butyl-2,3-dihydro-1H-indene-5-thiol | 245741-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 6-tert-butyl-2,3-dihydro-1H-indene-5-thiol
• CAS: 245741-46-2
• 化学式: C₁₃H₁₈S
• 分子量: 206.352
• InChiKey: ZXIMGIKBPMYTRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-tert-butyl-2,3-dihydro-1H-indene-5-thiol 在 potassium carbonate 、 三乙胺 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 生成 5-(6-tert-butylindan-5-yl)sulfanyl-4-hydroxy-2-phenethyl-2-phenyl-3H-pyran-6-one
  参考文献：
  名称：

  4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme

  摘要：

  5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S-1, S-2, S-1', and S-2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S-1' and S-2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00332-7
• 作为产物：
  描述：

  S-[(6-tert-butyl-2,3-dihydro-1H-inden-5-yl)] N,N-dimethylcarbamothioate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以95%的产率得到6-tert-butyl-2,3-dihydro-1H-indene-5-thiol
  参考文献：
  名称：

  4-Hydroxy-5,6-Dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1′ and S2′ of the HIV-1 protease enzyme

  摘要：

  5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S-1, S-2, S-1', and S-2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S-1' and S-2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00332-7

文献信息

• POLYCARBONATE RESIN COMPOSITION
  申请人：Mitsubishi Engineering-Plastics Corporation

  公开号：EP3546521A1

  公开（公告）日：2019-10-02

  Provided is a polycarbonate resin composition that can block ultraviolet light as well as light on the visible light side therefrom at wavelengths of 400 to 420 nm, and that is free of the problem of gas generation during molding. The polycarbonate resin composition characteristically comprises, per 100 parts by mass of a polycarbonate resin (A), (i) 0.02 to 1 parts by mass of a sesamol group-containing benzotriazole ultraviolet absorber (B1) having a maximum absorption wavelength of at least 375 nm in the absorption curve determined according to JIS K 7105 using the following formula, or (ii) 0.08 to 1 parts by mass of a sesamol group-containing benzotriazole ultraviolet absorber (B2) having a maximum absorption wavelength of at least 360 nm and less than 375 nm in the absorption curve determined according to JIS K 7105 using the following formula; and 0.01 to 0.5 % by mass of a stabilizer (C).

  本发明提供了一种聚碳酸酯树脂组合物，它可以阻挡波长为 400 至 420 纳米的紫外线和可见光，并且在成型过程中不会产生气体。该聚碳酸酯树脂组合物的特征在于，每 100 份聚碳酸酯树脂（A）中包含：(i) 0.02 至 1 份（质量份）含芝麻酚基团的苯并三唑紫外线吸收剂（B1），在根据 JIS K 7105 使用下式测定的吸收曲线中，该吸收剂的最大吸收波长至少为 375 纳米；或 (ii) 0.08 至 1 份（质量份）含芝麻酚基团的苯并三唑紫外线吸收剂（B2），在根据 JIS K 7105 使用下式测定的吸收曲线中，该吸收剂的最大吸收波长至少为 375 纳米。08 至 1 质量份的含芝麻酚基团的苯并三唑紫外线吸收剂 (B2)，在根据 JIS K 7105 使用下式测定的吸收曲线中，其最大吸收波长至少为 360 纳米且小于 375 纳米；以及 0.01 至 0.5 质量％的稳定剂 (C)。