三唑磷 | 24017-47-8

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机磷杀虫剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 三唑磷
• 中文别名: O,O-二乙基-O-(1-苯基-1,2,4-三唑-3-基)硫逐磷酸酯；三唑硫磷；0,0-二乙基-0-(1-苯基-1,2,4-三唑-3-基)硫代磷酸酯；0,0-二乙基-0-1-苯基-1,2,4-三唑-3-硫代磷酸酯；O,O-二乙基-O-(1-苯基-1,2,4-三唑-3-基)硫代磷酸酯
• 英文名称: triazophos
• 英文别名: O,O-diethyl O-1-phenyl-1H-1,2,4-triazol-3-yl phosphorothioate；O,O-diethyl-O-1-phenyl-1H-1,2,4-triazol-3-yl phosphorothioate；O,O-diethyl O-(1-phenyl-1,2,4-triazole-3-yl)thiophosphate；O,O-diethyl O-1-phenyl-1H-imidazol-4-yl phosphorothioate；3-(o,o-diethyl)-1-phenyl thiophosphoryl-1,2,4-triazol；diethoxy-[(1-phenyl-1,2,4-triazol-3-yl)oxy]-sulfanylidene-λ5-phosphane
• CAS: 24017-47-8
• 化学式: C₁₂H₁₆N₃O₃PS
• mdl: MFCD00055327
• 分子量: 313.317
• InChiKey: AMFGTOFWMRQMEM-UHFFFAOYSA-N

物化性质

• 熔点：
  0-5°C
• 沸点：
  260°C
• 密度：
  1.247
• 闪点：
  25 °C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 物理描述：
  Yellowish oil. Used to control insects, mites, and nematodes. Not registered as a pesticide in the U.S. (EPA, 1998)
• 颜色/状态：
  Yellowish-brown oil
• 蒸汽压力：
  2.9X10-6 mm Hg at 30 °C
• 稳定性/保质期：

  避免接触强氧化剂

• 保留指数：
  2280.3

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  90.5
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

在大鼠中，通过橄榄油管饲给予放射性化合物，剂量为每只大鼠0.56毫克（相当于每天每千克体重3.1-4.3毫克），连续12天。...尿液中的主要代谢物是尿素-14C，占通过此途径排出的放射活性的85%。在尿液中检测到的其他代谢物包括与葡萄糖醛酸结合的(3-14C)1-苯基-1,2,4-三唑-3-醇、(3-14C)1-苯基半碳酰胺和(14C)半碳酰胺，这三种代谢物各占尿液中消除的14C的3-5%。还发现了两种未知代谢物的低浓度。在粪便中，未改变的(14C)三唑磷（占粪便中总活性的40%）和(3-14C)1-苯基-1,2,4-三唑-3-醇（占活性的60%）被确定。...

... In male and female rats intubated with the radioactive compound in olive oil at a dose of 0.56 mg/rat (equivalent to 3.1-4.3 mg/kg bw per day) for 12 consecutive days. ... The main urinary metabolite was urea-14C, representing 85% of the radioactivity excreted by this route. Other metabolites detected in the urine were (3-14C)1-phenyl-1,2,4-triazol-3-ol, (3-14C)1-phenylsemicarbazide and (14C)semicarbazide, all conjugated with glucuronic acid. Each of these three metabolites accounted for 3-5% of the 14C eliminated in urine. Low concentrations of two unidentified metabolites were also found. In the feces, unchanged (14C)triazophos (40% of the total activity in feces) and (3-14C)1-phenyl-1,2,4-triazol-3-ol (60% of the activity) were identified. ...

来源:Hazardous Substances Data Bank (HSDB)

代谢

三唑磷在比格犬体内的代谢命运进行了研究...通过胃插管给两只母犬以芝麻油为溶剂的(14C)三唑磷，剂量为4.4-4.8 mg/kg体重。尿液排泄占主导，24小时后平均占给药剂量的85%，48小时后达到92%。粪便消除在24小时后占给药剂量的0.3%，48小时后为7.2%。血药浓度在2小时后达到最大值。48小时后，血液中检测不到放射性。...因为没有在实验结束时杀死动物，所以没有测定组织中的残留浓度。从定性上看，三唑磷在犬体内的代谢命运与大鼠相似。尿液中含有与大鼠相同的三个代谢物，即1-苯基-3-羟基-(1H)-1,2,4-三唑(占给药剂量的18%)及其葡萄糖苷酸(60%)和硫酸(5%)结合物。一种仅在犬尿液中发现的代谢物(占给药剂量的11%)，被认为是1-苯基-3-羟基-(1H)-1,2,4-三唑代谢物的另一种硫酸酯结合物。从定量上看，这种代谢物在分析时犬尿液中的含量(占给药剂量的18%)比大鼠(43%)少。在犬体内也观察到了葡萄糖苷酸结合物的不稳定性及其潜在转化为自由代谢物，而犬尿液中葡萄糖苷酸代谢物(占给药剂量的60%)比大鼠(36%)略高的浓度被认为不具有显著性。尿液中未检测到未改变的三唑磷。粪便中含有低浓度的三唑磷和自由的1-苯基-3-羟基-(1H)-1,2,4-三唑代谢物以及约0.7、0.3和7.3%给药剂量的五种未识别的代谢物。...

The metabolic fate of triazophos was examined in beagle dogs ... two female dogs were treated by gastric intubation with (14C)triazophos at a dose of 4.4-4.8 mg/kg bw in sesame oil. Urinary excretion predominated, representing an average of 85% of the administered dose after 24 hr and 92% after 48 hr. Fecal elimination accounted for 0.3% of the administered dose after 24 hr and and 7.2% after 48 hr. Maximal blood concentrations were attained after 2 hr. After 48 hr, no radioactivity was detectable in blood. ... Residual concentrations in tissues were not determined because the animals were not killed at termination. Qualitatively, the metabolic fate of triazophos in dogs was similar to that in rats. The urine contained the same three metabolites as in rats, namely 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole (18% of the administered dose) and its glucuronide (60%) and sulfate (5%) conjugates. One metabolite was found only in dog urine (representing 11% of the administered dose), which was thought to be another sulfate ester conjugate of the 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole metabolite. Quantitatively, less of this metabolite was present in dog urine (18% of the administered dose) at the time of analysis than in rats (43%). The instability of the glucuronide conjugate and its potential conversion to the free metabolite were also observed in dogs, and the somewhat higher concentration of the glucuronide metabolite in the urine of dogs (60% of the administered dose) than of rats (36%) was considered not to be significant. Unchanged triazophos was not detected in urine. The feces contained low concentrations of triazophos and the free 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole metabolite as well as five unidentified metabolites at about 0.7, 0.3 and 7.3% of the administered dose, respectively. ...

来源:Hazardous Substances Data Bank (HSDB)

代谢

有机磷杀虫剂三唑磷在23只雌性Wistar（WISKf（SPF 71））大鼠体内的代谢命运进行了研究，这些大鼠通过胃管单次口服给予了约5 mg/kg体重的标记在第3位的放射性三唑磷（放射性纯度为98%）的芝麻油溶液...三唑磷的葡萄糖苷酸缀合物不稳定，在室温下明显转化为母化合物。尿液中未检测到未改变的三唑磷。...

The metabolic fate of triazophos was studied in 23 female Wistar (WISKf (SPF 71)) rats given triazophos labeled at the 3 position (radiochemical purity, 98%) as a single oral dose of about 5 mg/kg bw in sesame oil by gastric intubation...The glucuronide was unstable and was apparently converted to the parent compound at room temperature. Unchanged triazophos was not detected in urine. ...

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

其他毒物 - 有机磷

Other Poison - Organophosphate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

大鼠LC50 = 450毫克/立方米/4小时

LC50 (rat) = 450 mg/m3/4h

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

一个昏迷的病人，全身出汗，瞳孔缩小，衣物或呼吸中有杀虫剂的气味，并且肌肉出现颤动，这是有机磷中毒的典型表现。... 管理的具体步骤包括以下内容。1. 去污。... 2. 气道。如有必要，建立气道。... 3. 呼吸状态。事实上，这些病人由于多种原因经常出现呼吸窘迫。... 4. 心脏监测。... 5. 胆碱酯酶水平。... 6. 普瑞洛昔姆。普瑞洛昔姆是有机磷中毒的首选治疗方法，应几乎用于所有临床上有显著有机磷中毒的病人，特别是那些肌肉颤动和虚弱的病人。... 7. 阿托品。阿托品是有机磷中毒的生理性拮抗剂。当怀疑有机磷中毒时，应基于临床情况给予试验剂量的阿托品。/有机磷中毒/

A comatose patient who is diaphoretic, has pinpoint pupils and the odor of an insecticide on clothing or breath, and is noted to have muscle fasciculations represents the classic presentation of organophosphate poisoning. ... Specific steps in management include the following. 1. Decontamination. ... 2. Airway. Establish an airway if necessary. ... 3. Respiratory Status. Respiratory distress, in fact, is commonly found in these patients from multiple causes. ... 4. Cardiac Monitoring. ... 5. Cholinesterase Level. ... 6. Pralidoxime. Pralidoxime is the treatment of choice for organophosphate poisoning and should be used for nearly all patients with clinically significant organophosphate poisoning, particularly those patients with muscular fasciculations and weakness. ... 7. Atropine. Atropine is the physiologic antidote for organophosphate poisoning. A trial dose of atropine should be instituted on clinical ground when one suspects organophosphate intoxication. /Organophosphate poisoning/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

阿托品是治疗有机磷中毒的首选解毒药。虽然通常需要的阿托品总量较少，但推荐的初始剂量相同。普拉立多辛通常也是必需的，可能会降低阿托品的效果（尤其是与甲萘威一起使用时）。...患者需要大约6-12小时的阿托品治疗，但所有严重中毒的患者在最后一次阿托品剂量后至少应观察24小时。/有机磷中毒/

Atropine is the antidote of choice as in organophosphate poisoning. Although the total amount of atropine required usually is less, the same initial doses are recommended. Pralidoximine usually is necessary and may reduce the effectiveness of atropine (especially with carbaryl). ... Patients require approximately 6-12 hr of atropine treatment, but all significantly poisoned patients should be observed at least 24 hr after the last atropine dose. /Organophosphate poisoning/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

气道保护。确保呼吸道畅通。必要时对患者进行气管插管，并使用大口径吸痰设备吸出分泌物。如果呼吸抑制，通过机械辅助肺通气给予氧气。在给予阿托品之前尽可能改善组织氧合，以最小化心室颤动的风险。在严重中毒的情况下，可能需要机械支持肺通气数天。/有机磷农药/

Airway protection. Ensure that a clear airway exists. Intubate the patients and aspirate the secretions with a large-bore suction device if necessary. Administer oxygen by mechanically assisted pulmonary ventilation if respiration is depressed. Improve tissue oxygenation as much as possible before administering atropine, so as to minimize the risk of ventricular fibrillation. In severe poisonings, it may be necessary to support pulmonary ventilation mechanically for several days. /Organophosphate pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

三唑磷在比格犬体内的代谢命运进行了研究... 两只母犬通过胃管饲喂的方式接受了含有14C标记的三唑磷，剂量为4.4-4.8 mg/kg体重，用芝麻油作为溶剂。尿液排泄为主要途径，24小时后平均占给药剂量的85%，48小时后达到92%。粪便排泄在24小时后占给药剂量的0.3%，48小时后为7.2%。血药浓度在2小时后达到最高。48小时后，血液中检测不到放射性。... 由于在实验结束时没有处死动物，因此没有测定组织中的残留浓度。从质的方面来看，三唑磷在犬体内的代谢命运与大鼠相似。尿液中含有与大鼠相同的三个代谢物，即1-苯基-3-羟基-(1H)-1,2,4-三唑（占给药剂量的18%）及其葡萄糖苷酸（60%）和硫酸（5%）结合物。犬尿液中还发现了一种仅存在于犬尿液中的代谢物（占给药剂量的11%），认为这是1-苯基-3-羟基-(1H)-1,2,4-三唑代谢物的另一种硫酸酯结合物。从量的方面来看，在分析时，犬尿液中这种代谢物的含量（占给药剂量的18%）比大鼠（43%）少。在大鼠中也观察到了葡萄糖苷酸结合物的不稳定性及其潜在转化为自由代谢物，狗尿液中葡萄糖苷酸代谢物（占给药剂量的60%）的浓度略高于大鼠（36%）被认为是无统计学意义的。尿液中未检测到未改变的三唑磷。粪便中含有低浓度的三唑磷和自由的1-苯基-3-羟基-(1H)-1,2,4-三唑代谢物以及大约占给药剂量0.7%，0.3%和7.3%的五种未识别的代谢物。...

The metabolic fate of triazophos was examined in beagle dogs ... two female dogs were treated by gastric intubation with (14C)triazophos at a dose of 4.4-4.8 mg/kg bw in sesame oil. Urinary excretion predominated, representing an average of 85% of the administered dose after 24 hr and 92% after 48 hr. Fecal elimination accounted for 0.3% of the administered dose after 24 hr and 7.2% after 48 hr. Maximal blood concentrations were attained after 2 hr. After 48 hr, no radioactivity was detectable in blood. ... Residual concentrations in tissues were not determined because the animals were not killed at termination. Qualitatively, the metabolic fate of triazophos in dogs was similar to that in rats. The urine contained the same three metabolites as in rats, namely 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole (18% of the administered dose) and its glucuronide (60%) and sulfate (5%) conjugates. One metabolite was found only in dog urine (representing 11% of the administered dose), which was thought to be another sulfate ester conjugate of the 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole metabolite. Quantitatively, less of this metabolite was present in dog urine (18% of the administered dose) at the time of analysis than in rats (43%). The instability of the glucuronide conjugate and its potential conversion to the free metabolite were also observed in dogs, and the somewhat higher concentration of the glucuronide metabolite in the urine of dogs (60% of the administered dose) than of rats (36%) was considered not to be significant. Unchanged triazophos was not detected in urine. The feces contained low concentrations of triazophos and the free 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole metabolite as well as five unidentified metabolites at about 0.7, 0.3 and 7.3% of the administered dose, respectively. ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷杀虫剂三唑磷在23只雌性Wistar（WISKf（SPF 71））大鼠体内的代谢命运进行了研究，这些大鼠通过胃管单次口服给予了约5 mg/kg bw的用芝麻油稀释的三唑磷（在3位置标记，放射性纯度为98%）。其中20只动物用于研究排泄和代谢，另外三只用于血液分析。在给药后24、48和96小时收集了合并的尿液和粪便样本，并在给药后0、0.5、2、4、6、8、24和48小时采取了血液样本。血液中的最大浓度在大约4小时后达到……96小时后98%的回收率表明排泄相对完全。排泄的主要途径是尿液，在48小时内排出了>90%的给药放射性。48小时后，粪便排泄占给药剂量的4.5%。分析的组织（肝脏、肾脏、肺、心脏、大脑、脊髓和腹膜后及皮下脂肪）中残留的放射性浓度在肾脏和肝脏中最高，但仍然相对较低：<0.004 ppm。合并尿液中含有三种可识别的代谢物，1-苯基-3-羟基-(1H)-1,2,4-三唑（占给药剂量的43%）及其葡萄糖苷酸（36%）和硫酸结合物（13%）。葡萄糖苷酸不稳定，在室温下显然转化为了母化合物。尿液中未检测到未改变的三唑磷……

The metabolic fate of triazophos was studied in 23 female Wistar (WISKf (SPF 71)) rats given triazophos labeled at the 3 position (radiochemical purity, 98%) as a single oral dose of about 5 mg/kg bw in sesame oil by gastric intubation. Twenty animals were used to investigate excretion and metabolism and the three others for blood assays. Pooled urine and fecal samples were collected after 24, 48, and 96 hr, and blood samples were taken 0, 0.5, 2, 4, 6, 8, 24 and 48 hr after administration. The maximal concentrations in blood were attained after about 4 hr. ... The recovery rate of 98% after 96 hr indicates that excretion was relatively complete. The predominant route of excretion was urinary, with > 90% of the administered radioactivity excreted within 48 hr. Fecal elimination accounted for 4.5% of the administered dose after 48 hr. The residual concentrations of radioactivity in the tissues analyzed (liver, kidney, lung, heart, brain, spinal cord and retroperitoneal and subcutaneous fat) were highest in kidney and liver but were still relatively low: <0.004 ppm. Pooled urine contained three identifiable metabolites, 1-phenyl-3-hydroxy-(1H)-1,2,4-triazole (43% of the administered dose) and its glucuronide (36%) and sulfate conjugates (13%). The glucuronide was unstable and was apparently converted to the parent compound at room temperature. Unchanged triazophos was not detected in urine. ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

五只雄性和五只雌性Wistar SPF大鼠一次口服给予(14C)三唑磷(在唑环的3位置标记)的橄榄油,剂量为2.8毫克/只(相当于15-21毫克/千克体重),在48小时内通过尿液排出了给予剂量的76%,通过粪便排出了21%。性别间在消除速率或途径上没有显著差异。对处理后4天处死的动物组织进行分析,结果显示,肾脏、生殖腺、大脑、肌肉和皮肤中的14C残留物占给药剂量的<0.04%,肝脏中为0.089%,胃肠中为0.31%。在雄性和雌性大鼠中,以0.56毫克/只(相当于3.1-4.3毫克/千克体重每天)的剂量连续12天口服给予放射性化合物的橄榄油,也观察到了(14C)三唑磷的快速消除,在给药期间,尿液中回收了70-83%的给药剂量,粪便中回收了18-31%。在12天治疗结束后的4天内,大多数被分析的组织(皮下脂肪、肾脏、生殖腺、肝脏、大脑、肌肉和皮肤)中的14C残留物浓度没有超过给药剂量的0.0008%。例外的是胃肠道,仍含有0.5%的剂量。尚不清楚是否单独分析了单次和多次给药研究的尿液和粪便中的代谢物,以及代谢轮廓在定性和定量上是否相似。

Groups of five male and five female Wistar SPF rats given a single oral dose of (14C)triazophos (labeled at the 3 position of the triazole ring) in olive oil by intubation at a dose of 2.8 mg/rat (equivalent to 15-21 mg/kg bw), excreted 76% of the administered dose in urine and 21% in feces within 48 hr. No significant difference in the rate or route of elimination was found between the sexes. Analysis of tissues from animals killed 4 days after treatment showed that 14C residues represented < 0.04% of the administered dose in kidneys, gonads, brain, muscle and skin, 0.089% in liver and 0.31% in the gastrointestinal tract. Rapid elimination of (14C)triazophos was also observed in male and female rats intubated with the radioactive compound in olive oil at a dose of 0.56 mg/rat (equivalent to 3.1-4.3 mg/kg bw per day) for 12 consecutive days, with 70-83% of the administered dose recovered in urine and 18-31% in feces during the dosing period. Four days after the end of the 12-day treatment, the concentration of 14C residues in most of the tissues analyzed (subcutaneous fat, kidney, gonads, liver, brain, muscle and skin) did not exceed 0.0008% of the administered dose. The exception was the gastrointestinal tract, which still contained 0.5% of the dose. It is not clear whether urine and feces from the study with single and multiple doses were analyzed for metabolites separately and whether the metabolic profiles were qualitatively or quantitatively similar.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

(14)C-三唑磷，溶于油中，以单次和重复剂量给予白鼠。当以单次剂量给药时，76%的标记物在4天内通过尿液排出，21%通过粪便排出。当连续12天重复给药时，每天给药的标记物的69-83%通过尿液排出，18-30%通过粪便排出。粪便中含有未改变的三唑磷和其水解产物1-苯基-β-葡萄糖苷酸、苯基半碳酰胺葡萄糖苷酸和半碳酰胺葡萄糖苷酸。使用TLV、IR和MS对代谢物进行了鉴定。观察到了另外两种代谢物，但未鉴定出来。尿液中既未检测到三唑磷也未检测到其对应的氧化类似物。

(14)C-Triazophos, dissolved in oil, was administered to white rats in single and repeated doses. When given as a single dose, 76% of the applied label was excreted within 4 days in urine and 21% in feces. When given repeatedly on 12 consecutive days, 69-83% of the daily applied label was excreted in urine and 18-30% in feces. The feces contained unchanged triazophos and the hydrolysis product 1-phenyl-glucuronide, phenylsemicarbazide glucuronide and semicarvazide glucuronide. Identification of metabolites was made with TLV, IR and MS. Two other metabolites were observed but not identified. Neither triazophos nor the oxon analog were observed in urine.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  T
• 安全说明：
  S1/2,S36/37,S45,S60,S61
• 危险类别码：
  R50/53,R23/25,R21
• WGK Germany：
  3
• 海关编码：
  29280090
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 危险品运输编号：
  3018
• 储存条件：
  约4℃

SDS

第一部分：化学品名称

制备方法与用途

用途

三唑磷是一种广谱性有机磷杀虫、杀螨剂，兼有一定的杀线虫作用。它具有胃毒和触杀作用，并且能够渗入植物组织中。对危害棉花、粮食、果树等农作物的害虫（如螟虫、棉铃虫、红蜘蛛、蚜虫）有良好防治效果，同时对地下害虫、植物线虫、森林松毛虫也有显著作用。其持效期长达2周以上，尤其在杀灭鳞翅目昆虫卵方面表现尤为突出。

• 急性毒性：大白鼠急性经口LD50为66mg/kg。
• 其他毒性和安全性数据：对狗的胆碱酯酶活性有些抑制作用（使用含三唑磷100mg/kg剂量饲料喂狗90d），但无明显不良影响；对鲫鱼和鲤鱼有毒（48h内LD50分别为8.4mg/L、1mg/L）。对蜜蜂有致毒作用。

生产方法 一、合成1-苯基氨基脲

将苯肼盐酸盐和尿素混合，搅拌加热至150-160℃，反应产生氨气得到黄色熔物。冷却后水洗、过滤并用醇重结晶，得到熔点为172℃的1-苯基氨基脲。

二、合成1-苯基-3-羟基-1,2,4-三唑

在搅拌下将浓盐酸加入到苯肼和尿素的混合物中，反应后分去水分并冷却至90℃。加入甲酸及浓硫酸继续反应6h，再经滤洗、干燥得到中间产物，收率88%。

三、合成三唑磷

在250mL二甲苯中将1-苯基-3-羟基-1,2,4-三唑与O,O-二乙基硫代磷酰氯及催化剂碳酸钾搅拌反应4h，最终得到三唑磷（收率86%）。

其他信息 类别

农药

毒性分级

高毒

急性毒性

口服 - 大鼠 LD50: 57毫克/公斤

可燃性危险特性

受热分解有毒，可释放氧化磷、氧化硫及氧化氮气体。

储运特性

储存于通风低温干燥库房，并与食品原料分开储运。

灭火剂

使用砂土、干粉或泡沫灭火。

反应信息

• 作为产物：
  描述：

  sodium 1-phenyl-1H[1,2,4]triazol-3-olate 、 O,O-二乙基硫代磷酰氯 在 4-二甲氨基吡啶 、 苄基三乙基氯化铵 、 sodium dodecyl sulfate 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 2.5h， 以93.1%的产率得到三唑磷
  参考文献：
  名称：

  O,O-二烷基硫代氯代磷酸酯在水溶剂中酰化杂环醇阴离子的研究

  摘要：

  摘要 研究了一些杂环醇阴离子与 O,O-二烷基硫代磷酸氯酯的酰化反应。通过使用有效的相转移催化剂 (PTC)（苄基三乙基氯化铵 [BTEAC]）、酰化催化剂 (AC)（4-二甲氨基吡啶）和表面活性剂（十二烷基硫酸钠），在 50 °C 的水中获得更高的产率和更少的副产物)，在弱碱性（pH 9.5∼10）条件下。该反应也可用于合成其他高产率的杀虫剂。图形概要

  DOI：

  10.1080/10426507.2012.702824
• 作为试剂：
  描述：

  aqueous cadmium chloride 在 三唑磷 作用下， 以 二甲基亚砜 为溶剂， 生成 镉
  参考文献：
  名称：

  Comprehensive multi-omics investigation of sub-chronic toxicity induced by Cadmium and Triazophos Co-exposure in hook snout carps (Opsariichthys bidens)

  摘要：

  DOI：

  10.1016/j.jhazmat.2024.135104

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。

表征谱图