抑草蓬 | 136-25-4

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机氯杀虫剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 抑草蓬
• 中文别名: 2－（2，4，5一三瓴苯氧基）乙基－2，2二氨丙酸酯
• 英文名称: 2,2-dichloro-propionic acid-[2-(2,4,5-trichloro-phenoxy)-ethyl ester]
• 英文别名: 2,2-Dichlor-propionsaeure-[2-(2,4,5-trichlor-phenoxy)-aethylester]；2,2-dichloro-propanoic acid, 2-(2,4,5-trichlorophenoxy)ethyl ester；2-(2,4,5-trichlorophenoxy)ethyl-2,2-dichloropropionate；erbon；2-(2,4,5-trichlorophenoxy)ethyl 2,2-dichloropropanoate
• CAS: 136-25-4
• 化学式: C₁₁H₉Cl₅O₃
• 分子量: 366.456
• InChiKey: KMHZPJNVPCAUMN-UHFFFAOYSA-N

物化性质

• 熔点：
  49-50°
• 沸点：
  bp0.5 161-164°
• 密度：
  d450 1.55
• 颜色/状态：
  WHITE SOLID
• 溶解度：
  SOL IN ACETONE, ALCOHOL, KEROSENE, XYLENE; INSOL IN WATER
• 蒸汽压力：
  LOW
• 稳定性/保质期：
  燃烧会产生有毒的氯化物气体。
• 腐蚀性：
  NONCORROSIVE TO SPRAY EQUIPMENT

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

在绵羊中，Erbon迅速被水解为2-(2,4,5-三氯苯氧基)乙醇，并被氧化为2,4,5-T。

In sheep Erbon is rapidly hydrolyzed to 2-(2,4,5-trichlorophenoxy)ethanol and oxidized to 2,4,5-T.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

1. 用肥皂和水洗澡洗发，以去除皮肤和头发上的化学品。慢性皮肤病或对化学品过敏的人应避免使用除草剂，或采取特殊措施以避免接触。2. 用大量清水冲洗眼部10-15分钟，以去除化学品。3. 如果在喷洒过程中或之后吸入喷雾而出现疾病症状，请将受害者从接触中移开至少2天。只有在实施有效的呼吸防护措施时，才允许随后接触氯苯氧基化合物。/氯苯氧基化合物/

1. BATHE & SHAMPOO WITH SOAP & WATER TO REMOVE CHEMICALS FROM SKIN & HAIR. INDIVIDUALS WITH CHRONIC SKIN DISEASE OR KNOWN SENSITIVITY TO CHEMICALS SHOULD EITHER AVOID USING HERBICIDES OR TAKE EXTRAORDINARY MEASURES TO AVOID CONTACT. 2. FLUSH...CHEMICALS FROM EYES WITH COPIOUS AMOUNTS OF CLEAN WATER FOR 10-15 MINUTES. 3. IF SYMPTOMS OF ILLNESS OCCUR DURING OR FOLLOWING INHALATION OF SPRAY, REMOVE VICTIM FROM CONTACT...FOR AT LEAST 2 DAYS. ALLOW SUBSEQUENT CONTACT WITH CHLOROPHENOXY COMPOUNDS ONLY IF EFFECTIVE RESPIRATORY PROTECTION IS PRACTICED. /CHLOROPHENOXY COMPOUNDS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

如果摄入，通常会发生自发性呕吐。通常情况下，这会像插管和灌洗一样有效地清空胃部。如果未发生剧烈呕吐，且受害者完全清醒，使用吐根糖浆诱导呕吐（12岁及以上的成人30毫升；12岁以下的儿童15毫升），随后饮用1-2杯水。呕吐后，给予活性炭......30克活性炭与3-4盎司水（儿童），100克与8-10盎司水（成人）......以限制肠道中剩余除草剂的吸收。/氯苯氧基化合物/

4. IF...INGESTED, SPONTANEOUS EMESIS USUALLY OCCURS. ORDINARILY, THIS EMPTIES THE STOMACH AS EFFECTIVELY AS INTUBATION & LAVAGE. IF VIGOROUS EMESIS HAS NOT OCCURRED & IF VICTIM IS FULLY ALERT, INDUCE EMESIS WITH SYRUP OF IPECAC (ADULTS 12 YEARS & OLDER, 30 ML; CHILDREN UNDER 12 YEARS, 15 ML), FOLLOWED BY 1-2 GLASSES OF WATER. FOLLOWING EMESIS, ADMIN....ACTIVATED CHARCOAL /PRC- 30 G ACTIVATED CHARCOAL IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/...TO LIMIT ABSORPTION OF HERBICIDE REMAINING IN GUT. /CHLOROPHENOXY COMPOUNDS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

如果意识水平降低...通过插管、抽吸和灌洗/儿童用淡水，成人用等渗盐水/来排空胃部。由于石油馏分通常包含在氯苯氧基化合物中，胃插管存在因抽吸导致碳氢化合物性肺炎的风险。因此：A. 如果受害者失去意识或昏昏欲睡并且条件允许，在进行胃插管之前插入气管内管（如果有的话，使用带气囊的）。B. 在插管和灌洗过程中，保持受害者的头部低于胃部水平（采用特伦德伦堡姿势，或左侧卧位，床头向下倾斜）。保持受害者头部向左转。C. 尽可能经常抽吸咽部，以移除呛咳或呕吐的胃内容物。/氯苯氧基化合物/

5. IF CONSCIOUSNESS LEVEL IS DEPRESSED...EVACUATE STOMACH BY INTUBATION, ASPIRATION, & LAVAGE /PRC- WATER IN CHILDREN & ISOTONIC SALINE IN ADULTS/. BECAUSE PETROLEUM DISTILLATES ARE COMMONLY INCLUDED IN CHLOROPHENOXY FORMULATIONS, GASTRIC INTUBATION INCURS A RISK OF HYDROCARBON PNEUMONITIS FROM ASPIRATION. FOR THIS REASON: A. IF VICTIM IS UNCONSCIOUS OR OBTUNDED & FACILITIES ARE AT HAND, INSERT ENDOTRACHEAL TUBE (CUFFED, IF AVAILABLE) PRIOR TO GASTRIC INTUBATION. B. KEEP VICTIM'S HEAD BELOW LEVEL OF STOMACH DURING INTUBATION & LAVAGE (TRENDELENBURG, OR LEFT LATERAL DECUBITUS, WITH HEAD OF TABLE TIPPED DOWNWARD). KEEP VICTIM'S HEAD TURNED TO LEFT. C. ASPIRATE PHARYNX AS REGULARLY AS POSSIBLE TO REMOVE GAGGED OR VOMITED STOMACH CONTENTS. /CHLOROPHENOXY COMPOUNDS/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

5. 在抽吸胃内容物和洗胃之后，灌入...活性炭.../PRC- 30克活性炭溶于3-4盎司水（儿童），100克溶于8-10盎司水（成人）/ 以限制剩余毒素的吸收。不要灌入牛奶、奶油或含有植物或动物脂肪的其他物质，因为这些物质可能会增强吸收。6. 如果4小时内没有排便且患者完全清醒，给予硫酸钠，0.25克/千克，作为泻药。如果肾功能充足，等剂量的硫酸镁和柠檬酸盐同样适用。保留的镁可能会抑制中枢神经系统功能。/氯苯氧基化合物/

5. AFTER ASPIRATION OF GASTRIC CONTENTS & WASHING OF STOMACH, INSTILL...ACTIVATED CHARCOAL.../PRC- 30 G ACTIVATED CHARCOAL IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/ TO LIMIT ABSORPTION OF REMAINING TOXICANT. DO NOT INSTILL MILK, CREAM, OR OTHER MATERIALS CONTAINING VEGETABLE OR ANIMAL FATS, AS THESE ARE LIKELY TO ENHANCE ABSORPTION. 6. IF BOWEL MOVEMENT HAS NOT OCCURRED IN 4 HOURS & PATIENT IS FULLY CONSCIOUS, GIVE SODIUM SULFATE, 0.25 G/KG, AS CATHARTIC. MAGNESIUM SULFATE & CITRATE, IN COMPARABLE DOSAGES, ARE EQUALLY SUITABLE IF RENAL FUNCTION IS ADEQUATE. RETAINED MAGNESIUM MAY DEPRESS CNS FUNCTION. /CHLOROPHENOXY COMPOUNDS/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

ERBON能被叶子和根部吸收。由于它在土壤中具有持久性，对多年生阔叶杂草的主要效果来自于根部吸收。吸收后，该化合物能有效地转移到生长点。

ERBON IS ABSORBED BY BOTH FOLIAGE & ROOTS. AS IT IS PERSISTENT IN THE SOIL, ITS MAJOR EFFECT ON PERENNIAL BROADLEAVED WEEDS RESULTS FROM ROOT UPTAKE. FOLLOWING ABSORPTION, THE CMPD IS EFFECTIVELY TRANSLOCATED TO GROWING POINTS.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xn,N
• 安全说明：
  S61
• 危险类别码：
  R22,R51/53
• 海关编码：
  2915900090
• 储存条件：
  库房应保持通风、低温和干燥，并将储存的物资与食品原料分开进行储运。

制备方法与用途

类别：农药
毒性分级：中毒
急性毒性：口服-大鼠 LD50: 1000 毫克/公斤；口服-小鼠 LD50: 912 毫克/公斤
可燃性危险特性：燃烧时产生有毒氯化物气体
储运特性：应存放在通风、低温和干燥的库房中，并与食品原料分开储存和运输
灭火剂：干粉、泡沫或砂土

反应信息

• 作为产物：
  描述：

  2,2-二氯丙酸 、 2-(2,4,5-三氯苯氧基)乙醇 在 硫酸 、 1,2-二氯乙烷 作用下， 生成 抑草蓬
  参考文献：
  名称：

  Alpha-alpha-dichloropropionates of the haloaryloxy loweralkanols

  摘要：

  公开号：

  US02754324A1

文献信息

• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• [EN] MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO<br/>[FR] MOLÉCULES PRÉSENTANT UNE UTILITÉ EN TANT QUE PESTICIDE, ET LEURS INTERMÉDIAIRES, COMPOSITIONS ET PROCÉDÉS
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2017040194A1

  公开（公告）日：2017-03-09

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions aga inst such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫有用的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的杀虫剂组合物，以及使用这种杀虫剂组合物对抗这些害虫的过程。这些杀虫剂组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下化学式（“化学式一”）的分子。
• MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20170210723A1

  公开（公告）日：2017-07-27

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的组合物，以及使用这种分子和组合物对抗这些害虫的过程。这些分子和组合物可以用作杀螨剂、杀虫剂、杀螨剂、杀软体动物剂和杀线虫剂。本文件披露了具有以下式（“式一”）的分子。
• HYDRAZONYL GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：US20190177319A1

  公开（公告）日：2019-06-13

  An object of the present invention is to develop and provide a novel agricultural and horticultural insecticide in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like. Provided is a hydrazonyl group-containing condensed heterocyclic compound or a salt thereof, preferably a condensed heterocyclic compound represented by the general formula (1): wherein R 1 represents, for example, an alkyl group, R 2 represents, for example, a hydrogen atom, R 3 and R 4 each represent, for example, an alkyl group, a haloalkyl group or an acyl group, A 1 represents, for example, a nitrogen atom, A 2 represents, for example, N-Me or an oxygen atom, A 3 represents, for example, a carbon atom or a nitrogen atom, A 4 represents, for example, C—H, m represents, for example, 2, and n represents, for example, 1}, or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.

  本发明的一个目的是开发并提供一种新型农艺和园艺杀虫剂，鉴于昆虫害虫等造成的损害仍然巨大，以及在农业、园艺等领域作物生产中出现的对现有杀虫剂具有抗性的昆虫害虫。 提供了一种含有肼酰基的稠合杂环化合物或其盐，优选为通式(1)表示的稠合杂环化合物： 其中R1代表例如烷基，R2代表例如氢原子，R3和R4各自代表例如烷基、卤代烷基或酰基，A1代表例如氮原子，A2代表例如N-Me或氧原子，A3代表例如碳原子或氮原子，A4代表例如C—H，m代表例如2，n代表例如1}，或其盐；一种包含该化合物或其盐作为活性成分的农艺和园艺杀虫剂；以及使用该杀虫剂的方法。
• [EN] MACROCYCLIC PICOLINAMIDES AS FUNGICIDES<br/>[FR] PICOLINAMIDES MACROCYCLIQUES À UTILISER EN TANT QUE FONGICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2017116954A1

  公开（公告）日：2017-07-06

  The invention relates to macrocyclic picolinamides of Formula (I) and their use as fungicides.

  本发明涉及式(I)所示的大环吡啶酰胺及其作为杀菌剂的应用。

表征谱图