四氢-5-羟基-1H-嘧啶-2-酮 | 1852-18-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 四氢-5-羟基-1H-嘧啶-2-酮
• 英文名称: tetrahydro-5-hydroxy-2(1H)-pyrimidinone
• 英文别名: 5-hydroxytetrahydropyrimidin-2-one；Tetrahydro-5-hydroxy-1H-pyrimidin-2-one；5-hydroxy-1,3-diazinan-2-one
• CAS: 1852-18-2
• 化学式: C₄H₈N₂O₂
• mdl: MFCD03931656
• 分子量: 116.12
• InChiKey: PZSCGIVZIUKDAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  210-211 °C
• 沸点：
  446.0±38.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H317,H319
• 储存条件：
  请将产品存放在室温、干燥且密封的环境中。

反应信息

• 作为反应物：
  描述：

  四氢-5-羟基-1H-嘧啶-2-酮 在 硝酸 、 乙酸酐 作用下， 生成 1,3-dinitro-5-nitryloxy-tetrahydro-pyrimidin-2-one
  参考文献：
  名称：

  The Reaction of Amines with 2-Nitramino-1,3-diaza-2-cycloalkenes

  摘要：

  DOI：

  10.1021/ja01163a113
• 作为产物：
  描述：

  径尿酸 在 硫酸 作用下， 生成 四氢-5-羟基-1H-嘧啶-2-酮
  参考文献：
  名称：

  Tafel; Reindl, Chemische Berichte, 1901, vol. 34, p. 3288

  摘要：

  DOI：

文献信息

• ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM, MASK BLANK PROVIDED WITH ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM, PHOTOMASK, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, ELECTRONIC DEVICE, COMPOUND, AND METHOD FOR PRODUCING COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20160280621A1

  公开（公告）日：2016-09-29

  The composition contains an alkali-soluble resin and a crosslinking agent that is represented by the following General Formula (I). In the formula, each of R 1 and R 6 independently represents a hydrogen atom or a hydrocarbon group having 5 or less carbon atoms; each of R 2 and R 5 independently represents an alkyl group, a cycloalkyl group, an aryl group, or an acyl group; and each of R 3 and R 4 independently represents a hydrogen atom or an organic group having 2 or more carbon atoms, and R 3 and R 4 may be bonded to each other to form a ring.

  该组合物包含一种碱溶性树脂和一种由下列通式（I）表示的交联剂。在该式中，R1和R6各自独立地表示氢原子或具有5个或更少碳原子的碳氢基团；R2和R5各自独立地表示烷基、环烷基、芳基或酰基；R3和R4各自独立地表示氢原子或具有2个或更多碳原子的有机基团，且R3和R4可以结合形成环。
• POLYMERIZABLE MONOMERS
  申请人：Domon Daisuke

  公开号：US20120029193A1

  公开（公告）日：2012-02-02

  A monomer of formula (1) is provided wherein R 1 is hydrogen or a monovalent C 1 -C 6 hydrocarbon group, and R 2 is a group having polymerization functionality. Using the monomer, crosslinking units can be incorporated into a polymer chain. A chemically amplified negative resist composition comprising a base polymer having crosslinking units incorporated therein has a high sensitivity and forms a resist pattern with minimized LER.

  提供了一个式子为（1）的单体，其中R1是氢或一价的C1-C6碳氢基团，R2是具有聚合功能的基团。使用这种单体，可以将交联单元并入聚合物链中。具有交联单元的基聚合物的化学放大负性光阻组合物具有高灵敏度，并形成具有最小LER的光阻图案。
• <i>S,S</i>-Dimethyl Dithiocarbonate:  A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas
  作者：Man-kit Leung、Jun-Liang Lai、King-Hang Lau、Hsiao-hua Yu、Hsiang-Ju Hsiao

  DOI：10.1021/jo9522825

  日期：1996.1.1
• Polymer, chemically amplified negative resist composition, and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2412733B1

  公开（公告）日：2016-03-23
• New Azt Conjugates as Potent Anti-HIV Agents
  作者：Zhengqing You、Henry Joung Lee

  DOI：10.1080/15257770500377789

  日期：2006.1

  In an attempt to discover anti-HIV agents with much reduced cytotoxicity from the currently available HIV-reverse transcriptase inhibitors, AZT conjugates of cholanic acids, 2-imidazolidone-4- carboxylic acid and its derivatives, and N, N'-disubstituted 5-hydroxy-tetrahydropyrimidin-2-ones have been synthesized and their anti-HIV profiles determined with CEM-SS cell line. The AZT conjugates with 2-imidazolidone-4- carboxylic acid and 2-pyrrolidone-5-carboxylic acid through an ester linkage, and with N,N'-diphenyl-5-hydroxy-tetrahydropyrimidin-2-one through a succinate tether showed significantly higher therapeutic indexes than AZT while they also retained or enhanced AZT's anti-HIV activity. Thus, structural features that favor the desired therapeutic profile of the conjugates appear to include a five-membered ring cyclic urea or lactam, and six-membered ring cyclic urea with N,N'-diphenyl substitution.