11-溴十一烷基丙-2-烯酸酯 | 33795-48-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 11-溴十一烷基丙-2-烯酸酯
• 英文名称: 11-bromoundecyl acrylate
• 英文别名: 11-acryloyloxyundecyl bromide；11-Bromoundecyl prop-2-enoate
• CAS: 33795-48-1
• 化学式: C₁₄H₂₅BrO₂
• 分子量: 305.255
• InChiKey: QRRINDUBPGYGKG-UHFFFAOYSA-N

物化性质

• 沸点：
  345.0±15.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  11-溴十一烷基丙-2-烯酸酯 在 sodium iodide 作用下， 以 丁酮 为溶剂， 反应 3.0h， 生成 Acrylic acid 11-iodo-undecyl ester
  参考文献：
  名称：

  自由基环化形成大环内酯

  摘要：

  大环合成练习曲 ayant au moins 11 链子par加成分子内自由基 d'丙烯酸酯 d'ω-碘代烷基 ou de fumarates d'乙基和 ω-碘代烷基。电影

  DOI：

  10.1021/ja00250a036
• 作为产物：
  描述：

  1,11-十一烷二醇 在 四溴化碳 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 11-溴十一烷基丙-2-烯酸酯
  参考文献：
  名称：

  自由基环化形成大环内酯

  摘要：

  大环合成练习曲 ayant au moins 11 链子par加成分子内自由基 d'丙烯酸酯 d'ω-碘代烷基 ou de fumarates d'乙基和 ω-碘代烷基。电影

  DOI：

  10.1021/ja00250a036

文献信息

• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。
• Ruthenium-Catalyzed Direct Dehydrogenative Cross-Coupling of Allyl Alcohols and Acrylates: Application to Total Synthesis of Hydroxy β-Sanshool, ZP-Amide I, and Chondrillin
  作者：Dattatraya H. Dethe、Nagabhushana C B

  DOI：10.1021/acs.orglett.0c00200

  日期：2020.2.21

  Ru-catalyzed oxidative coupling of allyl alcohols and activated olefins has been developed by C(allyl)-H activation of allyl alcohols providing efficient and direct access to synthetically useful α,β-unsaturated enone intermediates. Synthetic utility of this method was demonstrated by its application to synthesis of bioactive natural products such as Hydroxy-β-sanshool, ZP-amide I, Chondrillin, Plakorin

  烯丙醇的C（烯丙基）-H活化已开发出Ru催化的烯丙醇与活化烯烃的氧化偶联，可提供直接有效地获得合成上有用的α，β-不饱和烯酮中间体的途径。该方法在合成具有生物活性的天然产物（例如羟基-β-山梨醇，ZP-酰胺I，软骨素，白粉蛋白和（+）-顺式-索拉明A）中的应用证明了其实用性。
• LC Acrylic Monomers Incorporating Monothiobenzoate Unit
  作者：Laurent Caillier、Frédéric Guittard、Elisabeth Taffin de Givenchy、Serge Geribaldi

  DOI：10.1080/15421400590955154

  日期：2005.6.1

  ABSTRACT The development of LC monophenyl unit is of a great interest for reach low cost LC materials. The aim of this work was to demonstrate the possibility to obtain monomer incorporating single phenyl unit for LC field. We report the synthesis and the characterization of acrylic monomers in fluorinated series which differ by the lengthening of the hydrocarbon spacer linking the acrylic part to

  摘要 LC 单苯基单元的开发对于实现低成本的 LC 材料具有重要意义。这项工作的目的是证明获得包含单个苯基单元的单体用于 LC 领域的可能性。我们报告了氟化系列中丙烯酸单体的合成和表征，它们的不同之处在于将丙烯酸部分连接到“介晶”核心的烃间隔基的延长。LC 行为由 DSC 和 POM 装置确定。该烃间隔层长度的增加显着减小了近晶型中间相的跨度。对于长间隔，没有观察到介晶现象。
• Preparation of an Antibacterial Poly(ionic liquid) Graft Copolymer of Hydroxyethyl Cellulose
  作者：Fanny Joubert、R. Paul Yeo、Gary J. Sharples、Osama M. Musa、David R. W. Hodgson、Neil R. Cameron

  DOI：10.1021/acs.biomac.5b01300

  日期：2015.12.14

  Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ∼80% and a ĐM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.

  通过RAFT聚合，使用末端炔基黄原酸酯作为转移剂，制备了不同聚合度（10、50和100）的聚离子液体（P(IL)s），单体转化率高达约80%，P(IL)100的ĐM为1.5。随后，将P(IL)链与15N标记的叠氮功能化羟乙基纤维素（HEC）偶联，形成具有不同链长和接枝密度的HEC接枝共聚物，通过（13C和15N）CP-MAS NMR和FT-IR光谱进行表征。HEC-g-P(IL)s对大肠杆菌和金黄色葡萄球菌的抗菌活性测试表明，其抗菌活性与已知的抗生素氨苄西林相当，显示了接枝共聚物对细菌的高效活性。此外，HEC-g-P(IL)s对大肠杆菌的抗菌效果略优于金黄色葡萄球菌。随着P(IL)10在HEC骨架上的接枝密度降低，接枝共聚物对两种细菌的活性均有所下降。这些发现表明，HEC-g-P(IL)有可能作为消毒剂化合物得到应用，例如在涂料配方中。
• Microwave-Assisted Synthesis of a New Hydantoin Monomer for Antibacterial Polymeric Materials
  作者：Mauro Iannelli、Fabio Bergamelli、Giancarlo Galli

  DOI：10.1071/ch08479

  日期：——

  containing fluorinated and hydantoin (5,5-dimethylimidazolidine-2,4-dione) moieties were prepared by free radical polymerization of 2-(perfluorooctyl)ethyl acrylate and the synthesized monomer with the aim of obtaining low surface energy polymeric materials with properties of contact-active biocides. Polymeric films were treated with a bleaching solution in order to convert the hydantoin units to N-halamines

  丙烯酸11-（4,4-二甲基-2,5-二氧杂咪唑啉-1-基）十一烷基丙烯酸酯使用微波辐射通过两步程序合成。通过丙烯酸2-（全氟辛基）乙酯和合成的单体的自由基聚合反应，制备了含有氟化和乙内酰脲（5,5-二甲基咪唑烷-2,4-二酮）部分的聚丙烯酸酯，目的是获得低表面能的聚合物材料具有接触活性杀菌剂的特性。用漂白溶液处理聚合物膜，以便将乙内酰脲单元转化为N-卤胺，这是众所周知的接触活性杀菌剂。为实现可再生的杀菌作用，氯化反应的可逆性已通过傅里叶变换衰减全反射进行了研究。进行的初步生物学测试巨大芽孢杆菌证明了所制备材料的有效杀菌性能。