N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline | 20012-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline
• 英文别名: Benzyl-m-(bis-2-hydroxyethylamino)phenylether；Benzyl-m-(di-2-hydroxyethylamino)phenylether；2-[N-(2-hydroxyethyl)-3-phenylmethoxyanilino]ethanol
• CAS: 20012-18-4
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: ROEGCUNCZFKJCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline 在 palladium 10% on activated carbon 、 氢气 、 碳酸氢钠 、 三乙胺 、 sodium chloride 作用下， 以 乙醇 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 20.0~160.0 ℃ 、405.33 kPa 条件下， 反应 59.33h， 生成 4'-(3-hydroxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride
  参考文献：
  名称：

  Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

  摘要：

  A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable (NRR3)-R-2 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via pi-pi interaction. Introduction of substituting group on the N-4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 mu M/kg, sc) and holds promise for development as a mechanically new analgesic drug. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.052
• 作为产物：
  描述：

  3-苄氧基苯胺 、 2-氯乙醇 在 calcium carbonate 、 potassium iodide 作用下， 以 水 为溶剂， 反应 8.0h， 以76%的产率得到N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline
  参考文献：
  名称：

  Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

  摘要：

  A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable (NRR3)-R-2 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via pi-pi interaction. Introduction of substituting group on the N-4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 mu M/kg, sc) and holds promise for development as a mechanically new analgesic drug. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.052

文献信息

• ELECTRO-OPTIC POLYMER
  申请人：National Institute of Information and Communications Technology

  公开号：EP3480224A1

  公开（公告）日：2019-05-08

  An object of the present invention is to provide a novel electro-optic polymer. Another object of the present invention is to provide a novel electro-optic polymer with a low alicyclic methacrylate monomer content. The polymer according to the present invention is a polymer comprising (a) a base polymer having a reactive group (A), (b) an electro-optic molecule having a plurality of reactive groups (B), and a bond (C) formed by reaction of the reactive group (A) with the plurality of reactive groups (B), the bond (C) being at least one type of bond selected from the group consisting of a (thio) ester bond, a (thio) urethane bond, a (thio) urea bond and a (thio)amide bond.

  本发明的一个目的是提供一种新型电光聚合物。本发明的另一个目的是提供一种脂环族甲基丙烯酸酯单体含量低的新型电光聚合物。根据本发明的聚合物是一种聚合物，包括：(a) 具有活性基团 (A) 的基体聚合物；(b) 具有多个活性基团 (B) 的电光分子、和由活性基团（A）与多个活性基团（B）反应形成的键（C），键（C）至少是一种选自（硫代）酯键、（硫代）氨基甲酸酯键、（硫代）脲键和（硫代）酰胺键的键。
• Electro-optic polymer
  申请人：NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY

  公开号：US11236188B2

  公开（公告）日：2022-02-01

  An object of the present invention is to provide a novel electro-optic polymer. Another object of the present invention is to provide a novel electro-optic polymer with a low alicyclic methacrylate monomer content. The polymer according to the present invention is a polymer comprising (a) a base polymer having a reactive group (A), (b) an electro-optic molecule having a plurality of reactive groups (B), and a bond (C) formed by reaction of the reactive group (A) with the plurality of reactive groups (B), the bond (C) being at least one type of bond selected from the group consisting of a (thio)ester bond, a (thio)urethane bond, a (thio)urea bond and a (thio)amide bond.

  本发明的一个目的是提供一种新型电光聚合物。本发明的另一个目的是提供一种脂环族甲基丙烯酸酯单体含量低的新型电光聚合物。根据本发明的聚合物是一种聚合物，包括：(a) 具有活性基团 (A) 的基体聚合物；(b) 具有多个活性基团 (B) 的电光分子、以及由活性基团 (A) 与多个活性基团 (B) 反应形成的键 (C)，该键 (C) 至少是一种选自(硫代)酯键、(硫代)聚氨酯键、(硫代)脲键和(硫代)酰胺键的键。
• Edwards,P.D. et al., Journal of the Chemical Society. Perkin transactions I, 1973, p. 2397 - 2402
  作者：Edwards,P.D. et al.

  DOI：——

  日期：——
• POLYCARBONATE HAVING ELECTRO-OPTIC EFFECT, METHOD FOR PRODUCING SAME, AND LIGHT CONTROL ELEMENT WHICH USES SAID POLYCARBONATE
  申请人：TEIJIN LIMITED

  公开号：US20200407498A1

  公开（公告）日：2020-12-31

  The purpose of the present invention is to provide: a novel polymer which has an electro-optical effect; a method for producing such a polymer; and a light control element which uses such a polymer. The present invention relates to a non-crosslinkable polycarbonate which contains a moiety that has electro-optical characteristics. The present invention also relates to a method for producing a polycarbonate, which comprises a step for reacting a bisphenol compound, a diol compound that has electro-optical characteristics, and a phosgene in the presence of an acid binding agent and solvent. The present invention also relates to a light control element which comprises such polycarbonate.
• VIOLET EXCITABLE TANDEM DYES, AND METHODS FOR MAKING AND USING THE SAME
  申请人：Becton, Dickinson and Company

  公开号：US20230295440A1

  公开（公告）日：2023-09-21

  Violet excitable tandem dyes are provided. Tandem dyes of embodiments of the invention include: a non-conjugated polymeric backbone; one or more violet excitable donor fluorophores linked to the non-conjugated polymeric backbone; and one or more acceptor fluorophores linked to the non-conjugated polymeric backbone; where the donor and acceptor fluorophores are in energy transfer relationship. Also provided are methods of making and using the tandem dyes, as well as kits that include the dyes and find use in embodiments of the methods.