bis(4-hydroxymethylphenyl)methanone | 162896-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-hydroxymethylphenyl)methanone
• 英文别名: 4,4'-bis-hydroxymethyl-benzophenone；4,4'-Bis-hydroxymethyl-benzophenon；Bis[4-(hydroxymethyl)phenyl]methanone
• CAS: 162896-89-1
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: KDASSJFYTJBZFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  469.3±40.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(4-hydroxymethylphenyl)methanone 在 硝酸 、 溶剂黄146 作用下， 生成 bis-(4,4′-formyl)benzophenone
  参考文献：
  名称：

  Connerade, Bulletin des Societes Chimiques Belges, 1933, vol. 42, p. 311,319

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(4-bromomethylphenyl)methanone 在 高氯酸 、 mercury(II) oxide 作用下， 以 乙二醇二甲醚 为溶剂， 反应 1.0h， 以72%的产率得到bis(4-hydroxymethylphenyl)methanone
  参考文献：
  名称：

  Photophysical Properties of Three Methanofullerene Derivatives

  摘要：

  The [6,6]-ring bridged methanofullerenes 61,61-bis[4-tert-butylbenzoate]-1,2-dihydro-1,2-methanofullerene[60] (1), 61,61-bis[4-(tert-butyldiphenylsilyloxymethyl)phenyl]-1,2-dihydro-1,2-methanofullerene[60] (2), and 61-[(ethoxycarbonyl)methylcarboxylate]-1,2-dihydro-1,2-methanofullerene[60] (3) were synthesized by the Diederich method (3) or the Wudl method via tosylhydrazone salts (1 and 2). Groundstate absorption spectra of the methanofullerenes in toluene and cyclohexane solutions are presented and possible assignments discussed. The sharp, 430 nm transition is associated with the existence of less than 60 pi electrons, whereas a broad band peaking at 495 nm as well as weak features in the 700 nm region could be related to forbidden transitions of C-60. The allowed transitions of C,, in the UV region are modified relatively little in the methanofullerenes. Laser flash photolysis and pulse radiolysis techniques were used to obtain triplet-triplet absorption spectra between 400 and 1100 nm and determine photophysical properties. The three methanofullerenes have very similar T-T spectra, with a strong peak at 720 nm whose molar absorption coefficient is of the order of 14000 M(-1)cm(-1) somewhat lower than the 20200 M(-1)cm(-1) measured for the corresponding 750 nm band of C-60 Values near unity were determined for Phi(Delta) the quantum yield for O-1(2)((1) Delta(g)) production by energy transfer from the triplet state of the three methanofullerenes, implying that the quantum yield of triplet production of each is approximate to 1. The results indicate that it is possible for the spectroscopic and photophysical properties of methanofullerenes to vary little with the nature of the methano adduct and to undergo only slight modifications with respect to the corresponding properties of C-60. UP to now, this has been found valid only when the functionalization does not involve an electron donor, The biological photosensitization efficiencies of these methanofullerenes are therefore expected to be similar to those of C-60 but with their hydrophobicity and intracellular site delivery modulated by the nature of the methano-adduct.

  DOI：

  10.1002/(sici)1521-3765(19980210)4:2<270::aid-chem270>3.0.co;2-5

文献信息

• Ligand-Free Palladium-Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure
  作者：Hongyuan Zhao、Wei Han

  DOI：10.1002/ejoc.201600689

  日期：2016.9

  Arylboronic acids or potassium aryltrifluoroborates were readily oxidatively carbonylated to their corresponding diaryl ketones in high yields with high selectivities by ligand-free palladium-catalyzed homocoupling at atmospheric pressure. This novel method employs molecular oxygen or iodine as the oxidant and offers an attractive alternative to transition-metal-based oxidant systems.

  芳基硼酸或芳基三氟硼酸钾在常压下通过无配体钯催化的均偶联以高产率和高选择性容易地氧化羰基化为其相应的二芳基酮。这种新方法采用分子氧或碘作为氧化剂，为过渡金属基氧化剂体系提供了一种有吸引力的替代方案。
• [EN] WATER-SOLUBLE TRIOXANES AS POTENT AND SAFE ANTIMALARIAL AGENTS<br/>[FR] TRIOXANES HYDROSOLUBLES EN TANT QU'ANTIPALUDIQUES PUISSANTS ET SURS
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2000059501A1

  公开（公告）日：2000-10-12

  Biologically-active, water soluble, 3-substituted trioxanes of formula (I) wherein R represents a substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl group, and C12-(p-carboxy)benzyloxy trioxanes of formula (II) wherein R represents a substituted or unsubstituted alkyl, alkenyl, aryl or heteroaryl group and methods for their use as antiparasitic agents, particularly for the treatment of malaria.

  生物活性、水溶性的式子为（I）的3-取代三氧杂环烷，其中R代表取代芳基、取代或未取代的杂芳基或烷基，以及式子为（II）的C12-(对羧基)苯甲氧基三氧杂环烷，其中R代表取代或未取代的烷基、烯基、芳基或杂芳基，以及它们作为抗寄生虫药物的使用方法，特别是用于治疗疟疾。
• Photosensitive resin composition, method for manufacturing cured relief pattern, and semiconductor apparatus
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：US10831101B2

  公开（公告）日：2020-11-10

  A photosensitive resin composition containing a resin and a compound each having a structure specified by the present specification provides a cured film having excellent adhesiveness to copper wiring.

  一种光敏树脂组合物含有一种树脂和一种化合物，每种树脂和化合物都具有本说明书规定的结构，这种组合物提供的固化薄膜对铜线具有极佳的粘合性。
• Resin composition
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10990008B2

  公开（公告）日：2021-04-27

  The present invention provides a resin composition which can result in a cured film which has chemical resistance, low stress property, and high elongation property even by a heat treatment at a low temperature. The resin composition comprising an alkali-soluble resin (a) which contains a phenol skeleton having a crosslinking group and a phenol skeleton not having a crosslinking group and which has a weight average molecular weight in the range of 1,000 to 50,000, wherein the content ratio of the phenol skeleton having a crosslinking group to the total 100% by mole of structural units of the phenol skeleton having a crosslinking group and the phenol skeleton not having a crosslinking group is in the range of 5 to 90% by mole.

  本发明提供了一种树脂组合物，即使在低温下进行热处理，也能形成具有耐化学性、低应力特性和高伸长特性的固化膜。 该树脂组合物包括碱溶性树脂 (a)，它含有具有交联基团的苯酚骨架和不具有交联基团的苯酚骨架，其重量平均分子量在 1,000 至 50,000 之间，其中具有交联基团的苯酚骨架与具有交联基团的苯酚骨架和不具有交联基团的苯酚骨架的结构单元总数的 100%（以摩尔计）的含量比在 5 至 90%（以摩尔计）之间。
• Denholm, Alistair A.; George, Maurice H.; Hailes, Helen C., Journal of the Chemical Society. Perkin transactions I, 1995, # 5, p. 541 - 548
  作者：Denholm, Alistair A.、George, Maurice H.、Hailes, Helen C.、Tiffin, Peter J.、Widdowson, David A.

  DOI：——

  日期：——