3-Prop-2-enyl-1,3-oxazinan-2-one | 105856-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-Prop-2-enyl-1,3-oxazinan-2-one
• CAS: 105856-99-3
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: NKOTWNKQIZHKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(allyl(tert-butoxycarbonyl)amino)propyl 1H-imidazole-1-carboxylate 在 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 30.0h， 生成 3-Prop-2-enyl-1,3-oxazinan-2-one
  参考文献：
  名称：

  Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates

  摘要：

  The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 degrees C was observed only for the seven-membered ring progenitors. Applicability of the approach was illustrated by delta-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.092

文献信息

• Fujiwara, Masahiro; Baba, Akio; Matsuda, Haruo, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 1659 - 1663
  作者：Fujiwara, Masahiro、Baba, Akio、Matsuda, Haruo

  DOI：——

  日期：——
• FUJIWARA, MASAHIRO;BADA, AKIO;MATSUDA, HARUO, J. HETEROCYCL. CHEM., 26,(1989) N, C. 1659-1663
  作者：FUJIWARA, MASAHIRO、BADA, AKIO、MATSUDA, HARUO

  DOI：——

  日期：——
• Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates
  作者：Ralph J. Knipp、Rosendo Estrada、Palaniappan Sethu、Michael H. Nantz

  DOI：10.1016/j.tet.2014.03.092

  日期：2014.5

  The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 degrees C was observed only for the seven-membered ring progenitors. Applicability of the approach was illustrated by delta-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe. (C) 2014 Elsevier Ltd. All rights reserved.