4-[2-(2,4-dichloro-phenoxy)-ethoxy]-benzaldehyde | 938284-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-(2,4-dichloro-phenoxy)-ethoxy]-benzaldehyde
• 英文别名: 4-[2-(2,4-Dichlorophenoxy)ethoxy]benzaldehyde
• CAS: 938284-08-3
• 化学式: C₁₅H₁₂Cl₂O₃
• 分子量: 311.164
• InChiKey: MEHOLIJNUXDYMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  罗丹宁 、 4-[2-(2,4-dichloro-phenoxy)-ethoxy]-benzaldehyde 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 以80%的产率得到(Z)-5-(4-(2-(2,4-dichlorophenoxy)ethoxy)benzylidene)-2-thioxothiazolidin-4-one
  参考文献：
  名称：

  Novel glitazones: glucose uptake and cytotoxic activities, and structure–activity relationships

  摘要：

  In this article, two series of novel glitazones are reported for their synthesis, in vitro glucose uptake activity by the rat hemi-diaphragm, and in vitro cytotoxic activity against human carcinoma HEp-2 (epidermoid carcinoma of the larynx) and A549 (human lung cancer cell line) cells. Some of the compounds exhibit good glucose uptake and cytotoxic activities. Compound 5 with 2,4-dichlorophenol moiety connected to TZD via the two carbon linker has exhibited good glucose uptake activity. One of the compounds exhibits both cytotoxic and glucose uptake activities (compound 4). Illustrations about their synthesis, and in vitro glucose uptake and cytotoxic activities are described along with their structure-activity relationships.Designed, synthesized some novel glitazones and evaluated them for their glucose uptake and cytotoxic activities.

  DOI：

  10.1007/s00044-011-9792-0
• 作为产物：
  描述：

  对羟基苯甲醛 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 72.0h， 生成 4-[2-(2,4-dichloro-phenoxy)-ethoxy]-benzaldehyde
  参考文献：
  名称：

  Novel glitazones: glucose uptake and cytotoxic activities, and structure–activity relationships

  摘要：

  In this article, two series of novel glitazones are reported for their synthesis, in vitro glucose uptake activity by the rat hemi-diaphragm, and in vitro cytotoxic activity against human carcinoma HEp-2 (epidermoid carcinoma of the larynx) and A549 (human lung cancer cell line) cells. Some of the compounds exhibit good glucose uptake and cytotoxic activities. Compound 5 with 2,4-dichlorophenol moiety connected to TZD via the two carbon linker has exhibited good glucose uptake activity. One of the compounds exhibits both cytotoxic and glucose uptake activities (compound 4). Illustrations about their synthesis, and in vitro glucose uptake and cytotoxic activities are described along with their structure-activity relationships.Designed, synthesized some novel glitazones and evaluated them for their glucose uptake and cytotoxic activities.

  DOI：

  10.1007/s00044-011-9792-0

文献信息

• [EN] RENIN INHIBITORS<br/>[FR] INHIBITEURS DE LA RÉNINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2009087649A1

  公开（公告）日：2009-07-16

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式（1）的新型肾素抑制剂，涉及其合成中所涉及的新型中间体，其药学上可接受的盐以及含有它们的药物组合物。本发明还涉及一种制备一般式（1）化合物的方法，它们的互变异构形式，其药学上可接受的盐，含有它们的药物组合物，以及其合成中所涉及的新型中间体。
• RENIN INHIBITORS
  申请人：Desai Jigar

  公开号：US20100280024A1

  公开（公告）日：2010-11-04

  The present invention relates to renin inhibitors of formula (I), their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及公式（I）的肾素抑制剂，其药学上可接受的盐和含有它们的制药组合物。本发明还涉及制备通式（I）化合物、它们的互变异构体形式、药学上可接受的盐、含有它们的制药组合物以及其合成中所涉及的新型中间体的过程。
• Novel glitazones: glucose uptake and cytotoxic activities, and structure–activity relationships
  作者：B. R. Prashantha Kumar、S. Santhosh Kumar、Patel Viral、Ashish Wadhwani、R. Vadivelan、M. N. Satish Kumar、K. Elango、M. J. Nanjan

  DOI：10.1007/s00044-011-9792-0

  日期：2012.9

  In this article, two series of novel glitazones are reported for their synthesis, in vitro glucose uptake activity by the rat hemi-diaphragm, and in vitro cytotoxic activity against human carcinoma HEp-2 (epidermoid carcinoma of the larynx) and A549 (human lung cancer cell line) cells. Some of the compounds exhibit good glucose uptake and cytotoxic activities. Compound 5 with 2,4-dichlorophenol moiety connected to TZD via the two carbon linker has exhibited good glucose uptake activity. One of the compounds exhibits both cytotoxic and glucose uptake activities (compound 4). Illustrations about their synthesis, and in vitro glucose uptake and cytotoxic activities are described along with their structure-activity relationships.Designed, synthesized some novel glitazones and evaluated them for their glucose uptake and cytotoxic activities.