1-(4-甲氧基苯氧基)-2-丙醇 | 42900-54-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(4-甲氧基苯氧基)-2-丙醇
• 中文别名: 1-(4-甲氧苯氧基)-2-丙醇；甲氧苯丙醇
• 英文名称: 1-(4-methoxyphenoxy)propan-2-ol
• 英文别名: 1-(4-Methoxy-phenoxy)-propanol-(2)；1-(4-Methoxyphenoxy)-2-propanol
• CAS: 42900-54-9
• 化学式: C₁₀H₁₄O₃
• 分子量: 182.219
• InChiKey: VRJJZESAMSRBTH-UHFFFAOYSA-N

物化性质

• 熔点：
  63 °C
• 沸点：
  140 °C / 8mmHg
• 密度：
  1.082±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  常规情况下不会分解，也没有危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2909499000
• 储存条件：
  密封、阴凉、干燥保存。

SDS

1-(4-Methoxyphenoxy)-2-propanol Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: 1-(4-Methoxyphenoxy)-2-propanol

Revision number: 5

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols None
No signal word
Signal word
Hazard statements None
None
Precautionary statements:

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: 1-(4-Methoxyphenoxy)-2-propanol
Percent: >98.0%(GC)
CAS Number: 42900-54-9
Synonyms: 4-(2-Hydroxypropoxy)anisole
Chemical Formula: C10H14O3

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
1-(4-Methoxyphenoxy)-2-propanol

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Section 5. FIRE-FIGHTING MEASURES
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Keep container tightly closed. Store in a cool and dark place.
Storage conditions:
Store away from incompatible materials such as oxidizing agents.
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Form: Crystal- Powder
Colour: White - Almost white
Odour: No data available
pH: No data available
Melting point/freezing point:63°C
Boiling point/range: 140°C/1.1kPa
Flash point: No data available
Flammability or explosive
limits:
No data available
Lower:
Upper: No data available
No data available
Relative density:
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
1-(4-Methoxyphenoxy)-2-propanol

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Section 10. STABILITY AND REACTIVITY
Hazardous decomposition Carbon monoxide, Carbon dioxide
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
Not listed
UN-No:

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
1-(4-Methoxyphenoxy)-2-propanol

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基苯氧基)-2-丙醇 在 三溴化磷 作用下， 以 氯仿 为溶剂， 生成 2-Brom-1-(4-methoxy-phenoxy)-propan
  参考文献：
  名称：

  单胺氧化酶抑制剂。一系列取代的烷基肼的合成与评估。

  摘要：

  DOI：

  10.1021/jm00337a015
• 作为产物：
  描述：

  2,3-环氧丙基-4-甲氧基苯基醚 在 甲醇 、 三乙基硼 、 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成 1-(4-甲氧基苯氧基)-2-丙醇
  参考文献：
  名称：

  NaOH/BEt3 催化环氧化物区域选择性硼氢化制仲醇

  摘要：

  这里描述了环氧化物高效和区域选择性的硼氢化成仲醇，该反应由组合的 NaOH/BEt 3催化剂催化。这种不含过渡金属的催化体系适用于许多卤代化合物，并且在温和条件下对烯烃基团具有良好的耐受性。

  DOI：

  10.1002/ejoc.202200759

文献信息

• Ruthenium-Catalyzed Selective Hydrogenation of Epoxides to Secondary Alcohols
  作者：Subramanian Thiyagarajan、Chidambaram Gunanathan

  DOI：10.1021/acs.orglett.9b03995

  日期：2019.12.6

  A ruthenium(II)-catalyzed highly selective Markovnikov hydrogenation of terminal epoxides to secondary alcohols is reported. Diverse substitutions on the aryl ring of styrene oxides are tolerated. Benzylic, glycidyl, and aliphatic epoxides as well as diepoxides also underwent facile hydrogenation to provide secondary alcohols with exclusive selectivity. Metal-ligand cooperation-mediated ruthenium trans-dihydride

  据报道，钌（II）催化末端环氧化物向仲醇的高选择性马尔科夫尼科夫加氢反应。容许在苯乙烯氧化物的芳基环上的多个取代。苯甲酸，缩水甘油基和脂肪族的环氧化物以及二环氧化物也容易进行氢化，以提供具有独特选择性的仲醇。对于观察到的选择性的起源，设想了金属-配体配合介导的钌-二氢化钌的形成及其反应，该反应涉及氧和环氧化物的较少取代的末端碳。
• Convenient Continuous Flow Synthesis of <i>N</i>-Methyl Secondary Amines from Alkyl Mesylates and Epoxides
  作者：Gary Mathieu、Heena Patel、Hélène Lebel

  DOI：10.1021/acs.oprd.0c00193

  日期：2020.10.16

  process was developed to synthesize N-methyl secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-methyl secondary amines were produced in good to excellent yields, including a number of bioactive compounds or their precursors. Up to 10.6 g (88% yield) of an N-methyl secondary amine was produced in 140 min process time. The amination

  开发了第一连续流方法，以使用甲胺水溶液经由亲核取代从烷基甲磺酸酯和环氧化物合成N-甲基仲胺。以良好至优异的产率生产了多种N-甲基仲胺，包括许多生物活性化合物或其前体。在140分钟的处理时间内产生了多达10.6 g（88％的产率）的N-甲基仲胺。胺化过程包括在线后处理，并且甲磺酸酯原料也由相应的醇连续流产生。最后，开发了一种结合甲磺酸酯合成和亲核取代的在线工艺。
• Design, Synthesis, and Biological Evaluation of New Growth Inhibitors of <i>Trypanosoma cruzi</i> (Epimastigotes)
  作者：Andrea J. Schvartzapel、Li Zhong、Roberto Docampo、Juan B. Rodriguez、Eduardo G. Gros

  DOI：10.1021/jm9607616

  日期：1997.7.1

  search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenile hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma

  作为我们旨在寻找新的针对查加斯病的化学治疗剂的项目的继续，设计，合成并评估了几种与昆虫生长调节剂苯氧威和天然存在的昆虫幼体激素有关的药物，作为抗寄生虫的抗增殖剂对这种疾病负责。类异戊二烯衍生物（化合物33、34、36和37）是克鲁斯锥虫锥鞭毛虫的有效生长抑制剂。另外，考虑到对化合物30观察到的高活性和相关化合物的抑制作用，在这些抑制剂的极性极端处结合的烯丙基醚部分被证明是设计新药的有希望的基团。
• Complex catalyst, process for producing the complex catalyst, and process for producing alchohol derivative with the complex catalyst
  申请人：——

  公开号：US20040077487A1

  公开（公告）日：2004-04-22

  There are provided (asymmetric) complex catalysts comprising metal complexes and Lewis acids as components, the metal complex being of formula (1): 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same or different and are independently hydrogen, halogen, alkyl or the like; one of R 9 and R 10 is hydrogen and the other is alkyl of 1 to 4 carbon atoms or the like; Q is a single bond or alkylene of 1 to 4 carbon atoms; M is a metal ion; and A is a balancing counter ion or ligand; processes for the production of these complex catalysts; processes for the production of (optically active) alcohol derivatives, characterized in that cyclic ether compounds are reacted with phenol derivatives in the presence of these complex catalysts; and further processes for producing (optically active) nitrogen-containing heterocyclic compounds by reacting these alcohol derivatives with halogenated nitrogen-containing heterocyclic compounds in the presence of a base.

  提供了由金属配合物和路易斯酸组成的（不对称的）复杂催化剂，其中金属配合物的化学式为（1）：1其中R1、R2、R3、R4、R5、R6、R7和R8相同或不同，独立地是氢、卤素、烷基或类似物；R9和R10中的一个是氢，另一个是1至4个碳原子的烷基或类似物；Q是单键或1至4个碳原子的烷基；M是金属离子；A是平衡的反离子或配体；制备这些复杂催化剂的方法；制备（光学活性的）醇衍生物的方法，其特征在于在这些复杂催化剂的存在下，环氧化合物与酚衍生物反应；以及在碱的存在下，通过将这些醇衍生物与卤素化的含氮杂环化合物反应，制备（光学活性的）含氮杂环化合物的进一步方法。
• Heat-sensitive recording material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04994431A1

  公开（公告）日：1991-02-19

  A heat-sensitive recording material comprising a support having provided thereon a heat-sensitive color forming layer containing a colorless or slightly colored electron donating dye precursor and an electron accepting compound capable of forming color by the reaction with the electron donating dye precursor, wherein the heat-sensitive color forming layer contains a 1-alkoxyphenoxy-2-aryloxypropane. The recording material exhibits high sensitivity and satisfactory preservation stability.

  一种热敏记录材料，包括支撑体和在其上提供的热敏感色形成层，该层含有无色或略带颜色的电子供体染料前体和能够通过与电子供体染料前体反应形成颜色的电子受体化合物，其中热敏感色形成层含有1-烷氧基苯氧基-2-芳氧基丙烷。该记录材料具有高灵敏度和令人满意的保存稳定性。