2-amino-5'-chloro-3-(phenylsulfonyl)-7,8-dihydrospiro[chromene-4,3'-indoline]-2',5(6H)-dione | 1429767-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-amino-5'-chloro-3-(phenylsulfonyl)-7,8-dihydrospiro[chromene-4,3'-indoline]-2',5(6H)-dione
• 英文别名: 2'-amino-3'-(benzenesulfonyl)-5-chlorospiro[1H-indole-3,4'-7,8-dihydro-6H-chromene]-2,5'-dione
• CAS: 1429767-81-6
• 化学式: C₂₂H₁₇ClN₂O₅S
• 分子量: 456.906
• InChiKey: GVTORMKLORVCJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  sodium benzenesulfonate 在 2-羟基乙基铵乙酸盐 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-amino-5'-chloro-3-(phenylsulfonyl)-7,8-dihydrospiro[chromene-4,3'-indoline]-2',5(6H)-dione
  参考文献：
  名称：

  Ionic liquid catalyzed one-pot synthesis of novel spiro-2-amino-3-phenylsulfonyl-4H-pyran derivatives

  摘要：

  A series of novel spiro-2-amino-3-phenylsulfonyl-4H-pyran derivatives were synthesized via the three component, one pot reaction of phenylsulfonylacetonitrile and 1,3-dicarbonyl compounds with isatins or acenaphthenequinone in ethanol with a novel basic ionic liquid 2-hydroxyethyl ammonium acetate [H3N+CH2CH2OH][CH3COO-] (HEM) as catalyst. HEM was found to be a suitable and efficient catalyst for this condensation. This method has some distinct advantages such as mild reaction conditions, short reaction time, and environmental friendliness. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.02.073

文献信息

• Ionic liquid catalyzed one-pot synthesis of novel spiro-2-amino-3-phenylsulfonyl-4H-pyran derivatives
  作者：Shuai-Shuai Jin、Hong Wang、Hong-Yun Guo

  DOI：10.1016/j.tetlet.2013.02.073

  日期：2013.5

  A series of novel spiro-2-amino-3-phenylsulfonyl-4H-pyran derivatives were synthesized via the three component, one pot reaction of phenylsulfonylacetonitrile and 1,3-dicarbonyl compounds with isatins or acenaphthenequinone in ethanol with a novel basic ionic liquid 2-hydroxyethyl ammonium acetate [H3N+CH2CH2OH][CH3COO-] (HEM) as catalyst. HEM was found to be a suitable and efficient catalyst for this condensation. This method has some distinct advantages such as mild reaction conditions, short reaction time, and environmental friendliness. (C) 2013 Elsevier Ltd. All rights reserved.