1,1,2,2-tetrafluoro-5-(N-methylamino)-hex-4-en-3-one | 72721-37-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1,2,2-tetrafluoro-5-(N-methylamino)-hex-4-en-3-one
• 英文别名: (Z)-1,1,2,2-tetrafluoro-5-(methylamino)hex-4-en-3-one
• CAS: 72721-37-0
• 化学式: C₇H₉F₄NO
• 分子量: 199.148
• InChiKey: XWHAZVHGDGAGJE-ARJAWSKDSA-N

物化性质

• 沸点：
  181.3±40.0 °C(Predicted)
• 密度：
  1.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,2,2-tetrafluoro-5-(N-methylamino)-hex-4-en-3-one 在 氨 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 1,1,2,2-Tetrafluor-5-phenyl-aminohex-4-en-3-on
  参考文献：
  名称：

  Interaction of fluorine-containing ?-aminovinyl ketones with amines

  摘要：

  DOI：

  10.1007/bf00953227
• 作为产物：
  描述：

  1,1,2,2-Tetrafluor-5-phenyl-aminohex-4-en-3-on 在 氨 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 1,1,2,2-tetrafluoro-5-(N-methylamino)-hex-4-en-3-one
  参考文献：
  名称：

  Interaction of fluorine-containing ?-aminovinyl ketones with amines

  摘要：

  DOI：

  10.1007/bf00953227

文献信息

• Interaction of fluoroalkyl-containing ?-diketones with amines
  作者：V. I. Filyakova、Y. G. Ratner、N. S. Karpenko、K. I. Pashkevich

  DOI：10.1007/bf01430731

  日期：1996.9

  The composition of products of the interaction of asymmetric fluoroalkyl-containing beta-diketones with amines was studied. Mixtures of regioisomeric beta-aminovinylketones and products of cleavage and secondary condensation are formed, depending on the temperature, the solvent, the nature of the fluorinated and nonfluorinated substituents in the beta-diketone, and the basicity of the amine. The major product is a beta-aminovinylketone in which the NH2 group is removed from the fluoroalkyl substituent. No beta-aminovinylimines, products of condensation involving two electrophilic centers, were observed.
• Salt formation by reaction of fluorine-containing ?-diketones with amines
  作者：K. I. Pashkevich、V. I. Filyakova

  DOI：10.1007/bf00995699

  日期：1984.3
• Hydrolysis of fluoroalkyl-containing ?-aminovinyl ketones
  作者：L. N. Bazhenova、V. I. Filyakova、V. E. Kirichenko、K. I. Pashkevich

  DOI：10.1007/bf00957999

  日期：1991.3

  The kinetics of hydrolysis of fluoroalkyl-containing beta-aminovinyl ketones R1C(O)CHC(NHR3)R2, in which the substituents CF3 and HCF2CF2 are in the ketone (R1) or enamine parts of the molecule (R2), was studied. In acid (pH < 5) and alkaline (pH > 10) media, they hydrolyze with the formation of the corresponding amines and beta-diketones. In an alkaline medium, the beta-diketones undergo cleavage to fluorinated acids and methyl ketones. The rate constants of hydrolysis in an acid medium change within a range of four orders, depending on the nature of the substituents. The presence of a fluoroalkyl group at the enamine reaction center increases the hydrolysis rate. In an alkaline medium, the rate constants vary within one order.
• Interaction of fluorine-containing ?-aminovinyl ketones with amines
  作者：K. I. Pashkevich、V. I. Filyakova

  DOI：10.1007/bf00953227

  日期：1986.3