1-(甲氧基甲氧基)-2-[2-(甲氧基甲氧基)苯基]苯 | 121169-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(甲氧基甲氧基)-2-[2-(甲氧基甲氧基)苯基]苯
• 英文名称: 2,2'-bis(methoxymethoxy)-1,1'-biphenyl
• 英文别名: 2,2'-bis(methoxymethoxy)biphenyl；1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-；1-(methoxymethoxy)-2-[2-(methoxymethoxy)phenyl]benzene
• CAS: 121169-22-0
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: UQRJDQWLBHCSLR-UHFFFAOYSA-N

物化性质

• 沸点：
  353.5±37.0 °C(Predicted)
• 密度：
  1.104±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(甲氧基甲氧基)-2-[2-(甲氧基甲氧基)苯基]苯 在 盐酸 、 lithium aluminium tetrahydride 、 正丁基锂 、 三氯化磷 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 二氯甲烷 为溶剂， 反应 29.17h， 生成 8-[2-[di(propan-2-yl)amino]-4H-1,3,2-benzodioxaphosphinin-8-yl]-N,N-di(propan-2-yl)-4H-1,3,2-benzodioxaphosphinin-2-amine
  参考文献：
  名称：

  Bis-cycloSal-d4T-monophosphates:  Drugs That Deliver Two Molecules of Bioactive Nucleotides

  摘要：

  Bis-cycloSal-d4T-monophosphates have been synthesized as potentially anti-HIV active "dimeric" prodrugs of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (d4TMP). These pronucleotides display a mask-drug ratio of 1:2, a novelty in the field of pronucleotides. Both bis-cycloSal-d4TMP 6 and bis-5-methyl-cycloSal-d4TMP 7 showed increased hydrolytic stability as compared to their "monomeric" counterparts and a completely selective hydrolytic release of d4TMP. The hydrolysis pathway was investigated via P-31 NMR spectroscopy. Moreover, due to the steric bulkiness, compound 6 already displayed strongly reduced inhibitor potency toward human butyrylcholinesterase (BChE), while compound 7 turned out to be devoid of any inhibitory activity against BChE. Partial separation of the diastereomeric mixture of 6 revealed strong dependence of the pronucleotides' properties on the stereochemistry at the phosphorus centers. Both 6and 7 showed good activity against HIV-1 and HIV-2 in wild-type CEM cells in vitro. These compounds were significantly more potent than the parent nucleoside d4T 1in HIV-2-infected TK-deficient CEM cells, indicating an efficient TK-bypass.

  DOI：

  10.1021/jm0611713
• 作为产物：
  描述：

  1-(甲氧基甲氧基)苯 在 叔丁基锂 、 copper(I) bromide dimethylsulfide complex 、 lithium bromide 、 (3,5-dinitrophenyl)(4-methylpiperazin-1-yl)methanone 作用下， 以 乙醚 、 四氢呋喃 为溶剂， 以79%的产率得到1-(甲氧基甲氧基)-2-[2-(甲氧基甲氧基)苯基]苯
  参考文献：
  名称：

  芳基-芳基通过定向锂化和氧化偶联。

  摘要：

  通过定向锂化反应形成的芳基锂试剂会与铜（I）盐发生金属转移，形成有机铜盐，可以有效地氧化生成邻位取代的联芳基。

  DOI：

  10.1039/b501939g

文献信息

• Design of a Brønsted acid with two different acidic sites: synthesis and application of aryl phosphinic acid–phosphoric acid as a Brønsted acid catalyst
  作者：N. Momiyama、T. Narumi、M. Terada

  DOI：10.1039/c5cc06787a

  日期：——

  A Brønsted acid with two different acidic sites, aryl phosphinic acid–phosphoric acid, was synthesized and its catalytic performance was assessed.

  一种具有两个不同酸性位点的Brønsted酸，芳基膦酸-磷酸，已合成并评估了其催化性能。
• Biaryl-Based Macrocyclic and Polymeric Chiral (Salophen)Ni(II) Complexes:  Synthesis and Spectroscopic Study
  作者：Hui-Chang Zhang、Wei-Sheng Huang、Lin Pu

  DOI：10.1021/jo001276s

  日期：2001.1.1

  Polymeric/oligomeric and macrocyclic (salophen)Ni(II) complexes have been synthesized starting from both an achiral biphenol dialdehyde and an optically active BINOL dialdehyde. It was found that these polysalophens contain nonplanar coordination of Ni(II) units that are paramagnetic. This is different from the previously reported (salophen)Ni(II) complexes which are square planar and diamagnetic. The

  已从非手性双酚二醛和光学活性的BINOL二醛开始合成了高分子/低聚和大环（salophen）Ni（II）配合物。已发现这些聚salophophens包含顺磁性Ni（II）单元的非平面配位。这不同于先前报道的方形平面且抗磁性的（盐酚）Ni（II）配合物。非平面（salophen）Ni（II）单元使新的聚合Ni（II）络合物不同于为包含方形平面（salophen）Ni（II）单元的手性联芳基聚合物建议的螺旋结构。手性联萘单体与非手性联苯单体的共聚表明联萘单元的手性不沿着联苯聚合物链传播。
• Synthesis, crystal structure and magnetic properties of new trinuclear Copper(II) complexes with Biphenol−Based dinucleating ligands
  作者：Adelew Estifanos Filkale、Manoj Kumar Gangwar

  DOI：10.1016/j.molstruc.2020.128450

  日期：2020.10

  by the ligand donor atoms in the four-coordinate complex. The average indexes for 3e and 4e were found to be 0.42 and 0.43 respectively, signifying a considerable distortion from an idealized square planar, D4h geometry (τ4 = 0.0) or idealized tetrahedral, Td geometry (τ4 = 1.0). The average Cu⋯Cu distance between closest copper(II) ions in the complex 3e is 4.48 A. On the other hand, the single crystal

  摘要 (3,3'-双-((2,6-二甲基苯基)-亚氨基)甲基)-(1,1')-联苯-2,2'-二醇) (H2L2) 和 (3,3' -双-((2-甲氧基苯基))亚氨基)甲基)-(1,1')-联苯-2,2'-二醇) (H2L3) 与过量 [Cu2(OAc)4(H2O)2] 在存在下三乙胺得到新的三核配合物 [Cu(3,3'-bis-((R)-iminomethyl)-(1,1')-biphenyl-2,2'-dioxo)]3 [R = 2,6-Me2C6H3 (3e) 和 R = 2-OMeC6H3(4e)]。所得配合物通过元素分析、磁化率、EPR、UV-Vis、IR、CV 和单晶 X 射线衍射分析进行表征。3e 和 4e 的磁化率研究是在 5-300 K 下进行的，揭示了两种配合物中存在反铁磁相互作用。使用各向同性交换模型可以令人满意地再现实验数据，H = -J (S1S2 + S2S3 +
• meta-Selective C–H Borylation of Benzamides and Pyridines by an Iridium–Lewis Acid Bifunctional Catalyst
  作者：Lichen Yang、Nao Uemura、Yoshiaki Nakao

  DOI：10.1021/jacs.9b03138

  日期：2019.5.15

  We report herein the iridium-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2'-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. We also demonstrate the iridium-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. It is proposed that the Lewis acid-base interaction between the

  我们在此报告了通过使用新设计的带有烷基铝联苯氧化物部分的 2,2'-联吡啶 (bpy) 配体，铱催化的苯甲酰胺的间位选择性 CH 硼酸化。我们还展示了吡啶与带有烷基硼烷部分的 1,10-菲咯啉 (Phen) 配体的铱催化的 C3 选择性 CH 硼酸化。提出路易斯酸部分与氨基羰基或 sp2 杂化氮原子之间的路易斯酸碱相互作用加速反应并控制位点选择性。
• Asymmetric Hydrogenation Using Rhodium Complexes Generated from Mixtures of Monodentate Neutral and Anionic Phosphorus Ligands
  作者：Dominik J. Frank、Axel Franzke、Andreas Pfaltz

  DOI：10.1002/chem.201202408

  日期：2013.2.11

  anionic phosphorus ligands was synthesized and evaluated in the asymmetric rhodium‐catalyzed hydrogenation of functionalized olefins by using either catalysts containing identical ligands or catalysts generated from mixtures of two different ligands. We expected that the combination of an anionic ligand with a neutral ligand would favor the formation of hetero over homo bis‐ligand complexes due to charge

  通过使用含有相同配体的催化剂或由两种不同配体的混合物生成的催化剂，合成并评估了一系列单齿中性和阴离子磷配体，并在不对称铑催化的官能化烯烃加氢中进行了评估。我们预计，由于电荷排斥，阴离子配体与中性配体的组合将比杂双配体形成杂多。NMR光谱研究证实，电荷效应确实可以使平衡向杂双配体络合物转移。在一些情况下，中性膦与阴离子性膦，一种手性和另一种非手性的组合比两种中性配体的类似混合物具有更高的对映选择性。阴离子亚磷酰胺和中性磷酸二酯的混合物可获得最佳结果。据推测，在这种情况下，两个配体之间的氢键还稳定了杂配体组合。