3,3'-diformyl-2,2'-bis(methoxymethoxy)biphenyl | 160726-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-diformyl-2,2'-bis(methoxymethoxy)biphenyl
• 英文别名: 2,2'-Bis-(methoxymethoxy)-3,3'-Diformylbibenzene；3-[3-formyl-2-(methoxymethoxy)phenyl]-2-(methoxymethoxy)benzaldehyde
• CAS: 160726-28-3
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.337
• InChiKey: NKUWSYUXHLKJQZ-UHFFFAOYSA-N

物化性质

• 沸点：
  474.6±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,3'-diformyl-2,2'-bis(methoxymethoxy)biphenyl 在 盐酸 、 lithium aluminium tetrahydride 、 三氯化磷 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 二氯甲烷 为溶剂， 反应 22.17h， 生成 8-[2-[di(propan-2-yl)amino]-4H-1,3,2-benzodioxaphosphinin-8-yl]-N,N-di(propan-2-yl)-4H-1,3,2-benzodioxaphosphinin-2-amine
  参考文献：
  名称：

  Bis-cycloSal-d4T-monophosphates:  Drugs That Deliver Two Molecules of Bioactive Nucleotides

  摘要：

  Bis-cycloSal-d4T-monophosphates have been synthesized as potentially anti-HIV active "dimeric" prodrugs of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (d4TMP). These pronucleotides display a mask-drug ratio of 1:2, a novelty in the field of pronucleotides. Both bis-cycloSal-d4TMP 6 and bis-5-methyl-cycloSal-d4TMP 7 showed increased hydrolytic stability as compared to their "monomeric" counterparts and a completely selective hydrolytic release of d4TMP. The hydrolysis pathway was investigated via P-31 NMR spectroscopy. Moreover, due to the steric bulkiness, compound 6 already displayed strongly reduced inhibitor potency toward human butyrylcholinesterase (BChE), while compound 7 turned out to be devoid of any inhibitory activity against BChE. Partial separation of the diastereomeric mixture of 6 revealed strong dependence of the pronucleotides' properties on the stereochemistry at the phosphorus centers. Both 6and 7 showed good activity against HIV-1 and HIV-2 in wild-type CEM cells in vitro. These compounds were significantly more potent than the parent nucleoside d4T 1in HIV-2-infected TK-deficient CEM cells, indicating an efficient TK-bypass.

  DOI：

  10.1021/jm0611713
• 作为产物：
  描述：

  2,2'-二羟基联苯 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 6.0h， 生成 3,3'-diformyl-2,2'-bis(methoxymethoxy)biphenyl
  参考文献：
  名称：

  基于联芳基的大环和聚合手性（salophen）Ni（II）配合物：合成和光谱研究。

  摘要：

  已从非手性双酚二醛和光学活性的BINOL二醛开始合成了高分子/低聚和大环（salophen）Ni（II）配合物。已发现这些聚salophophens包含顺磁性Ni（II）单元的非平面配位。这不同于先前报道的方形平面且抗磁性的（盐酚）Ni（II）配合物。非平面（salophen）Ni（II）单元使新的聚合Ni（II）络合物不同于为包含方形平面（salophen）Ni（II）单元的手性联芳基聚合物建议的螺旋结构。手性联萘单体与非手性联苯单体的共聚表明联萘单元的手性不沿着联苯聚合物链传播。

  DOI：

  10.1021/jo001276s

文献信息

• Synthesis, crystal structure and magnetic properties of new trinuclear Copper(II) complexes with Biphenol−Based dinucleating ligands
  作者：Adelew Estifanos Filkale、Manoj Kumar Gangwar

  DOI：10.1016/j.molstruc.2020.128450

  日期：2020.10

  by the ligand donor atoms in the four-coordinate complex. The average indexes for 3e and 4e were found to be 0.42 and 0.43 respectively, signifying a considerable distortion from an idealized square planar, D4h geometry (τ4 = 0.0) or idealized tetrahedral, Td geometry (τ4 = 1.0). The average Cu⋯Cu distance between closest copper(II) ions in the complex 3e is 4.48 A. On the other hand, the single crystal

  摘要 (3,3'-双-((2,6-二甲基苯基)-亚氨基)甲基)-(1,1')-联苯-2,2'-二醇) (H2L2) 和 (3,3' -双-((2-甲氧基苯基))亚氨基)甲基)-(1,1')-联苯-2,2'-二醇) (H2L3) 与过量 [Cu2(OAc)4(H2O)2] 在存在下三乙胺得到新的三核配合物 [Cu(3,3'-bis-((R)-iminomethyl)-(1,1')-biphenyl-2,2'-dioxo)]3 [R = 2,6-Me2C6H3 (3e) 和 R = 2-OMeC6H3(4e)]。所得配合物通过元素分析、磁化率、EPR、UV-Vis、IR、CV 和单晶 X 射线衍射分析进行表征。3e 和 4e 的磁化率研究是在 5-300 K 下进行的，揭示了两种配合物中存在反铁磁相互作用。使用各向同性交换模型可以令人满意地再现实验数据，H = -J (S1S2 + S2S3 +
• ビフェノール化合物及びそれを用いるオレフィン重合用触媒並びにオレフィン重合体の製造方法
  申请人：日本ポリプロ株式会社

  公开号：JP2015155397A

  公开（公告）日：2015-08-27

  【課題】分子量の高いオレフィンを重合できる触媒活性の高い重合用触媒を形成する、簡易な合成経路で安価に製造可能な四座配位子を有する遷移金属錯体の提供。【解決手段】一般式（１）で表されるビフェノール化合物（Ｑ１及びＱ２はＣ１〜２０の二価の炭化水素基等；Ｑ３〜Ｑ８はＨ、Ｃ１〜２０の炭化水素基等；Ｔ１及びＴ２はＣ６〜２０のアリーロキシ基アミノ基等；ｍ及びｎは０〜２）【選択図】なし

  提供具有可以形成高催化活性的重合用催化剂，可用于廉价制备具有四座配位子的过渡金属配合物的简易合成途径，以便聚合高分子量烯烃。一般式（1）表示的联苯酚化合物（Q1和Q2为C1-20的二价碳氢基等；Q3-Q8为H、C1-20的碳氢基等；T1和T2为C6-20的芳氧基氨基等；m和n为0-2）。【选择图】无
• Chiral catalyst, process for preparing the same and its use in the oxidate coupling of naphthols
  申请人：Gong Liuzhu

  公开号：US20050256345A1

  公开（公告）日：2005-11-17

  The compound of this invention is a useful catalyst for the oxidative coupling of naphthol. Its originality lies in that it is a novel vanadium complex of Schiff's base formed by a chiral amino acid and a formyl biphenol or its derivative. Its axis chirality is induced to form by the chiral amino acid. It has the general formula: where R represents a benzyl, an isopropyl, an isobutyl or a tertiary butyl and the configuration of the amino acid is R or S. The compound can catalyze oxidative coupling of naphthol or its derivative to form binaphthol or its derivatives with a high optical purity.

  这项发明的化合物是一种用于萘酚氧化偶联的有用催化剂。其独特之处在于它是一种新颖的茜素碱的钒络合物，由手性氨基酸和甲酰联苯酚或其衍生物形成。其轴手性是由手性氨基酸诱导形成的。它的一般化学式为：其中R代表苄基、异丙基、异丁基或叔丁基，氨基酸的构型是R或S。该化合物可以催化萘酚或其衍生物的氧化偶联反应，形成具有高光学纯度的联萘酚或其衍生物。
• Directed ortho metalation reactions. Expedient synthesis of 3,3′-disubstituted 1,1′-bi-(2-phenols) (BIPOLS)
  作者：Andrew S. Parsons、Jesus M. Garcia、Victor A. Snieckus

  DOI：10.1016/s0040-4039(00)78337-7

  日期：1994.10

  Metalation-electrophile quench of the 1,1'-bi-(2-biphenol) bis OCONEt(2) and OMOM derivatives 1a-b provides a general route to 3,3'-disubstituted products 2a-b; dianionic ortho-Fries rearrangement of la furnishes, after acetylation, the 3,3'-bisamide 4 while Suzuki and Negishi cross coupling of 2a (E = I and ZnBr) affords 3,3'-diaryl derivatives 5a-b in good yields.
• Self-immobilizing binuclear neutral nickel catalyst for ethylene polymerization: Synthesis and catalytic studies
  作者：Hongliu Jiang、Fuan He、Jinshan Lu、Yuepeng Xing

  DOI：10.1016/j.molcata.2013.09.008

  日期：2013.12

  A allyl-substituted salicylaldimine proligand (Scheme 1, Compound 5) was prepared by a condensation reaction, which reacted with trans-[NiCl(Ph)(PPh3)(2)] to give a binuclear neutral nickel (II) complex [((4-Allyl-2,6-iPr(2)C(6)H(2)) NCH)C6H3ONi(PPh3)Ph](2) (Scheme 1, Complex 6). The structure of the complex was characterized by H-1 NMR, C-13 NMR and elemental analysis. This novel complex bearing allyl groups can be used as a self-immobilizing catalyst for the polymerization of ethylene and does not need a cocatalyst for their catalytic performance. The self-immobilizing catalytic systems not only possess high activity (up to 5.23 x 10(5) g of PE/(mol of Ni h)) but also can produce high-molecular-weight polyethylenes (Mw = (0.42-0.71) x 10(6)) with relatively broad molecular weight distributions (MWD = 2.83-3.11). According to the C-13 NMR analyses, the resultant polyethylenes contain a few branched chains mainly consisting of methyl branches. (C) 2013 Elsevier B.V. All rights reserved.