9-cyano-10-methylanthracene | 1467-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9-cyano-10-methylanthracene
• 英文别名: 10-methyl-9-anthracenecarbonitrile；10-cyano-9-methylanthracene；10-methyl-9-cyanoanthracene；9-methyl-10-cyanoanthracene；10-methyl-anthracene-9-carbonitrile；10-Methyl-anthracen-9-carbonitril；10-Methylanthracene-9-carbonitrile
• CAS: 1467-01-2
• 化学式: C₁₆H₁₁N
• 分子量: 217.27
• InChiKey: WZWRZJWPLAVPPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-cyano-10-methylanthracene 在 盐酸 、 sodium hydroxide 、 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 、 sodium carbonate 、 N-苄基氯化辛可宁丁 作用下， 以 二氯甲烷 为溶剂， 反应 34.5h， 生成 (S)-3-(10-Cyano-anthracen-9-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
  参考文献：
  名称：

  New Synthetic Amino Acids for the Design and Synthesis of Peptide-Based Metal Ion Sensors

  摘要：

  The syntheses of two new nonstandard amino acids, Flu (6) and YBp (20), and a new synthesis of Dmd (12) are reported. These residues exhibit fluorescence, metal-coordination, and fluorescence-quenching properties, respectively. These building blocks have been incorporated into peptides via solid phase peptide synthesis to afford the prototype fur a photoinduced electron transfer-based metal ion chemosensor. The fluorescence of the peptides is modulated upon metal binding. This results from a metal. ion-induced conformational change that brings the side chains of the Flu and Dmd amino acids into proximity, thereby favoring photoinduced electron transfer (PET) fluorescence quenching.

  DOI：

  10.1021/jo961466w
• 作为产物：
  描述：

  10-甲基蒽-9-甲醛 在 乙酸酐 作用下， 生成 9-cyano-10-methylanthracene
  参考文献：
  名称：

  Polar radicals. 16. Comments on a recently published mechanistic study of photobromination using bromotrichloromethane

  摘要：

  DOI：

  10.1021/jo01313a032

文献信息

• Practical synthesis of aromatic nitriles via gallium-catalysed electrophilic cyanation of aromatic C–H bonds
  作者：Kazuhiro Okamoto、Masahito Watanabe、Masahito Murai、Ryo Hatano、Kouichi Ohe

  DOI：10.1039/c2cc18008a

  日期：——

  A gallium-catalysed, direct cyanation reaction of aromatic and heteroaromatic C-H bonds with cyanogen bromide was developed as a practical synthetic method for the preparation of aromatic nitriles.

  开发了一种镓催化的芳香族和杂芳香族CH键与溴化氰的直接氰化反应，作为制备芳香腈的一种实用合成方法。
• [EN] ? (PI)-CONJUGATED FLUOROIONOPHORES AND METHOD FOR DETERMINING AN ALKALI ION<br/>[FR] FLUOROIONOPHORES p-CONJUGUÉS ET MÉTHODE DE DOSAGE D'UN ION ALCALIN
  申请人：UNIV POTSDAM

  公开号：WO2012120141A1

  公开（公告）日：2012-09-13

  The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion. Fluoroionophoric compounds of the general formula I are described Ionophore – π-Linker - Fluorophore (I) wherein the Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ion the π-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety. Variation of the ionophoric unit offers a broad spectrum of detectable K+ and Na+ -concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM. The fluoroionophores have great potential for application in fluorescent optode system based blood analyzing equipment for methods and kits for the determination of K+ and Na+ concentrations in biological systems, either in vitro or in vivo, using embodiments of the disclosed fluoroionophores.

  本发明涉及π-共轭氟离子探针，其制备方法以及它们的使用和一种用于确定碱金属离子的方法。描述了一般式I的氟离子探针化合物 离子载体 - π-连接体 - 荧光团（I），其中离子载体是含有一个或多个苯胺供体基团作为电子给体的冠醚或cryptand，与碱金属离子形成稳定络合物，π-连接体是芳香或杂芳共轭连接基团，荧光团是电子受体基团。离子载体单元的变化提供了广泛的可检测K+和Na+浓度范围，从约800 mM的高浓度到约3 mM的非常低浓度。这些氟离子探针在基于荧光光电系统的血液分析设备中具有巨大的应用潜力，用于检测生物系统中K+和Na+浓度的方法和试剂盒，无论是体外还是体内，都可以使用所披露的氟离子探针的实施方式。
• OsO4-Mediated Conversion of Primary Amines to Nitriles
  作者：Shouhai Gao、David Herzig、Binghe Wang

  DOI：10.1055/s-2001-12348

  日期：——

  Nitriles are very important intermediates in synthetic organic chemistry. Herein, we report our observation that certain primary amines can be converted to nitriles by trimethylamine N-oxide (TMO) under mild conditions in the presence of a catalytic amount of OsO4. Such a reaction could be used for synthetic purposes as well as for the analysis of functional group compatibility in designing reactions involving OsO4.

  腈是合成有机化学中非常重要的中间体。在此，我们报告了我们的观察结果：在温和的条件下，在一定量的 OsO4 催化下，三甲胺 N-氧化物（TMO）可将某些伯胺转化为腈。这种反应可用于合成目的，以及在设计涉及 OsO4 的反应时分析官能团的兼容性。
• Photophysics of aromatic thiourea derivatives and their complexes with anions. Fast and ultrafast spectroscopic investigations
  作者：Tiziana Del Giacco、Benedetta Carlotti、Stefano De Solis、Arianna Barbafina、Fausto Elisei

  DOI：10.1039/b927442a

  日期：——

  with nano- and femto-second time resolution. A complete picture of the excited state deactivation pathways of 1 and 2, where the main operative processes were fluorescence, intersystem crossing and internal conversion, was obtained. Even if steady-state measurements suggest that 1 and 2 selectively interact in the ground state with the anions H2PO4− and AcO−, time-resolved investigations demonstrate that

  为了收集有关荧光之间相互作用机理的详细信息 硫脲 衍生物和阴离子， 9- [4-（三氟甲基）苯基硫脲基甲基]蒽（1）与之对应10-氰基蒽合成（2）的衍生物并进行了研究。二甲基亚砜 和 机械化 通过使用吸收和发射稳态技术，在不存在和存在不同阴离子的情况下（醋酸-，H 2 PO 4 -，HSO 4 - ，和溴−）。阴离子识别机理的广泛研究还通过时间分辨的瞬态吸收光谱法进行，时间分辨率为纳秒和飞秒。获得了1和2的激发态失活途径的完整图片，其中主要的操作过程是荧光，系统间杂交和内部转化。即使稳态测量表明， 1和2选择性地与阴离子小时基态相互作用2 PO 4 -和醋酸-，时间分辨的研究表明，底物能够使所有四个阴离子络合。这类配合物的光物理特性已得到充分表征。阴离子主要修改的最低激发单重态的寿命，特别是在H的情况下， 2 PO 4 -和醋酸-，荧光发射和三重态形成的效率。特别是，没有发现进一步灭活过程
• PHOTOBASE GENERATOR
  申请人：Shiraishi Atsushi

  公开号：US20110028585A1

  公开（公告）日：2011-02-03

  The object of the present invention is to provide a photobase generator capable of efficiently generating amines (tertiary amines and amidine) high in catalytic activity by sensing light with a wavelength of from 350 to 500 nm (especially, from 400 to 500 nm). The present invention is a photobase generator characterized in being represented by general formula (1) or (2). Y + is a quaternary ammonio group of general formula (3) to (5), and X − is a counter anion selected from among a borate anion, a phenolate anion, and a carboxylate anion.

  本发明的目的是提供一种光敏基发生器，能够通过感应350至500纳米（特别是400至500纳米）波长的光，高效地生成催化活性高的胺（三级胺和酰胺）。本发明是一种光敏基发生器，其特征在于由通式（1）或（2）所表示。其中，Y+为通式（3）至（5）的四级铵基团，X-为从硼酸根离子、酚酸根离子和羧酸根离子中选择的对应阴离子。