N¹,N⁹-bis(trifluoroacetyl)dipropylenetriamine trifluoacetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N¹,N⁹-bis(trifluoroacetyl)dipropylenetriamine trifluoacetate
• 英文别名: bis[3-(2,2,2-trifluoroacetamido)propyl]ammonium trifluoroacetate；2,2,2-trifluoro-N-{3-[3-(2,2,2-trifluoroacetylamino)-propylamino]propyl}-acetamide trifluoroacetate；2,2,2-trifluoroacetic acid;2,2,2-trifluoro-N-[3-[3-[(2,2,2-trifluoroacetyl)amino]propylamino]propyl]acetamide
• 化学式: C₂HF₃O₂*C₁₀H₁₅F₆N₃O₂
• 分子量: 437.262
• InChiKey: JVZFELSDGQFCTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.35
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  N¹,N⁹-bis(trifluoroacetyl)dipropylenetriamine trifluoacetate 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 bis-(3-amino-propyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Lipophilic Pyrylium Salts in the Synthesis of Efficient Pyridinium-Based Cationic Lipids, Gemini Surfactants, and Lipophilic Oligomers for Gene Delivery

  摘要：

  Several new classes of pyridinium cationic lipids were synthesized and tested as gene delivery agents. They were obtained through a procedure that generates simultaneously the heterocyclic ring and the positively charged nitrogen atom, using lipophilic pyrylium salts as key intermediates that react with primary amines, yielding pyridinium salts. The choice of the appropriately substituted primary amine, diamine or polyamine, allows the design of the shape of the final lipids, gemini surfactants, or lipophilic polycations. We report also a comprehensive structure-activity relationship study that identified the most efficient structural variables at the levels of the hydrophobic anchor, linker, and counterion for these classes of pyridinium cationic lipids. This study was also aimed at finding the best liposomal formulation for the new transfection agents.

  DOI：

  10.1021/jm0601755
• 作为产物：
  描述：

  3,3'-二氨基二丙基胺 、 三氟乙酸乙酯 以 水 、 乙腈 为溶剂， 反应 4.0h， 以97%的产率得到N¹,N⁹-bis(trifluoroacetyl)dipropylenetriamine trifluoacetate
  参考文献：
  名称：

  通过酰胺氮与 Cu++ 的异常络合，在温和条件下切割酰胺的新型强健和多功能四齿连接基

  摘要：

  通过氮与 Cu++ 的相当不寻常的强制络合来削弱酰胺键的概念不仅限于三齿配体，并且在这项工作中也扩展到四齿配体。使用环状四齿配体无济于事，但开链和更灵活的四齿配体允许在络合后通过甲醇分解进行温和裂解。该原理被应用于固相化学新接头的开发，该接头被证明非常坚固，但在通过 Cu++ 络合激活后允许温和切割。它的稳定性和多功能性通过成功应用于大量不同类型的反应得到证明。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  DOI：

  10.1002/ejoc.200900291

文献信息

• Adjuvant
  申请人：Catchpole Ian Richard

  公开号：US20110045027A1

  公开（公告）日：2011-02-24

  The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof.

  本发明提供了一种新型的辅助剂，用于多核苷酸疫苗，特别是本发明提供了包含编码能够引起免疫反应的抗原的多核苷酸和包含免疫刺激量的双子星表面活性剂或其衍生物的辅助剂的免疫原性组合物。
• AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS
  申请人：Castro Mariano Javier

  公开号：US20090209472A1

  公开（公告）日：2009-08-20

  This invention relates to newly identified spermidine based surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the spermidine based compounds to facilitate the transfer of polynucleotides into cells.

  本发明涉及新鉴定的以精胺为基础的表面活性剂化合物，以及这些化合物的使用和生产。该发明还涉及使用以精胺为基础的化合物促进多核苷酸进入细胞的方法。
• Fluorescent sensing of non-steroidal anti-inflammatory drugs naproxen and ketoprofen by dansylated squaramide-based receptors
  作者：Giacomo Picci、M. Carla Aragoni、Massimiliano Arca、Claudia Caltagirone、Mauro Formica、Vieri Fusi、Luca Giorgi、Filippo Ingargiola、Vito Lippolis、Eleonora Macedi、Luca Mancini、Liviana Mummolo、Luca Prodi

  DOI：10.1039/d3ob00324h

  日期：——

  Bis-squaramide receptors L1–L4 bearing a dansyl moiety were considered as fluorescent probes for non steroidal antinflamatory drugs naproxene and ketoprofen.

  含有丹酰分子的双夸酰胺受体 L1-L4 被视为非甾体抗炎药物萘普生和酮洛芬的荧光探针。
• WO2006/136460
  申请人：——

  公开号：——

  公开（公告）日：——
• Phosphonolipids as non-viral vectors for gene therapy
  作者：Virginie Floch、Gwénaëlle Le Bolc'h、Christine Gable-Guillaume、Nathalie Le Bris、Jean-Jacques Yaouanc、Hervé des Abbayes、Claude Férec、Jean-Claude Clément

  DOI：10.1016/s0223-5234(99)80017-8

  日期：1998.12

  Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. (C) Elsevier, Paris.