p-(dodecyloxy)phenylacetic acid | 79794-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-(dodecyloxy)phenylacetic acid
• 英文别名: 4-dodecyloxyphenylacetic acid；Benzeneacetic acid, 4-(dodecyloxy)-；2-(4-dodecoxyphenyl)acetic acid
• CAS: 79794-88-0
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.472
• InChiKey: HQAAQSKXONDGQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-(dodecyloxy)phenylacetic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 10.0h， 以95%的产率得到4-dodecyloxyphenylacetic acid chloride
  参考文献：
  名称：

  Veber, M.; Fugnitto, R.; Strzelecka, H., Molecular Crystals and Liquid Crystals (1969-1991), 1983, vol. 96, p. 221 - 228

  摘要：

  DOI：
• 作为产物：
  描述：

  4-羟基苯乙酸甲酯 在 氢氧化钾 、 potassium carbonate 作用下， 以 甲醇 、 丙酮 为溶剂， 生成 p-(dodecyloxy)phenylacetic acid
  参考文献：
  名称：

  Analogs of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF

  摘要：

  A series of bis-aryl amide (13-57 and 66-81) and bis-aryl urea (58 and 85) antagonists of platelet-activating factor (PAF) was prepared that contain, separating the two aromatic rings, linear amide linkages of the form -(CH2)nCONH- (n = 0-2), -OCH2CONH-, and -(CH2)nNHCO- (n = 0-1), branched amide linkages of the form -(CH2)nN(COR)- (n = 1-3, R = CH3 or n-C3H7), and -N(COCH3)CH2-, and urea linkages of the form -NHCONH- and -CH2N(CONHCH3)-. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in the mouse, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Best activity was observed for compounds having linkages of the type -CH2CONH-, -CH2N(COR)-, and -CH2NHCO-. Many of these compounds inhibit PAF-induced platelet aggregation with IC50's under 1 muM.

  DOI：

  10.1021/jm00104a002

文献信息

• 4-Hydroxy-3-pyrrolin-2-ones and treatment of circulatory disorders
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04925868A1

  公开（公告）日：1990-05-15

  The present invention relates to a compound of the formula: ##STR1## wherein X is sulfur or optionally substituted imino group; Y is a bond, oxygen, phenylene, phenyleneoxy, or oxyphenyleneoxy; R.sup.1 is hydrogen or optionally substituted hydrocarbon residue; R.sup.2 is optionally substituted hydrocarbon residue; and R.sup.1 may form, together with the imino-nitrogen atom as X, a nitrogen-containing 5- to 7-membered ring, production and use thereof. The compound (I) of the present invention has an anti-oxidation activity and activities of preventing or improving functional disorders due to biologically active oxygen species, thus being useful as a pharmaceutical agent for prophylaxis and therapy of disorders in the circulatory system.

  本发明涉及一种具有以下通式的化合物：##STR1##其中X为硫或可任选取代的亚氨基；Y为键、氧、苯二烯、苯氧基或氧代苯氧基；R1为氢或可任选取代的烃基残基；R2为可任选取代的烃基残基；且R1可与作为X的亚氨基氮原子一起形成含氮的5至7元环，以及其制备和用途。本发明的化合物(I)具有抗氧化活性以及预防或改善由生物活性氧物种引起的功能障碍的活性，因此可作为预防和治疗循环系统疾病的药物。
• Polymeric malondialdehyde dianils—a novel type of electrically conducting polymers
  作者：Rudolf Gompper、Thomas J. J. Müller、Kurt Polborn

  DOI：10.1039/a801654b

  日期：——

  The reaction of vinamidinium salts withpara-substituted aromatic diamines gives rise to polymeric 2-aryl malonaldehyde dianils in good yields. Polymeric cyanines can be obtained from tetramethoxypropane and a pentamethine cyanine, respectively, and para-substituted aromatic diamines. The degree of polymerisation Pn (n=10–40) was estimated by measuring the intrinsic viscosity η. The polymers show high electrical powder conductivities (σ=0.03–50 S cm–1) after doping with iodine or FeCl3 .

  乙脒盐与对位取代的芳香族二胺反应可生成聚合物 2-芳基丙二醛二元胺，产量很高。聚合氰可以分别从四甲氧基丙烷和五甲氧基氰以及对位取代的芳香族二胺中获得。聚合度 Pn（n=10â40）是通过测量固有粘度 δ- 来估算的。在掺入碘或三氯化铁后，聚合物显示出很高的粉末电导率（Ï=0.03â50 S cmâ1）。
• Hydroxybutenolide derivatives, production and use thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04939274A1

  公开（公告）日：1990-07-03

  The present invention relates to a compound of the formula: ##STR1## wherein Y is a chemical bond, oxygen atom, phenyleneoxy, or oxyphenyleneoxy; R.sup.1 is hydrogen or hydrocarbon residue; and R.sup.2 is hydrocarbon residue having two or more carbon atoms, production and use thereof. The compound (I) of the present invention has an antioxidation activity and activities of preventing or improving functional disorders due to biologically active oxygen species, thus being useful as a pharmaceutical agent for prophylaxis and therapy of disorders in the circulatory system.

  本发明涉及一种化合物，其化学式为：##STR1## 其中，Y是化学键、氧原子、苯氧基或氧苯氧基；R.sup.1是氢或烃基残基；R.sup.2是具有两个或更多碳原子的烃基残基，以及其制备和用途。本发明的化合物(I)具有抗氧化活性和预防或改善由生物活性氧种引起的功能障碍的活性，因此可用作预防和治疗循环系统疾病的药物。
• 一类香豆素染料、可用于超声固化的复合引发剂、其制备方法和应用
  申请人：大连理工大学

  公开号：CN114196226A

  公开（公告）日：2022-03-18

  本发明公开了一类香豆素染料、可用于超声固化的复合引发剂、其制备方法和应用。所述的一类香豆素染料具有通式Ⅰ的结构，且可用于制备用于超声固化的复合引发剂，本发明进一步涉及超声固化方法，所述方法包括步骤：将超声复合引发剂与丙烯酸类单体混合，得到混合溶液；设定超声参数；对所述混合溶液进行超声波处理，得超声固化产物；对产物进行后处理；用重量法测定产物的最终转化率。采用本发明提供的超声复合引发剂及超声固化方法可制备3D立体模型，对超声设备要求低，可操作性强，与光固化技术相比所需时间短、固化深度更强。
• Photochemical cyclopropanation in aqueous micellar media – experimental and theoretical studies
  作者：Joseph P. Milton、Adam Milanowski、Martin Andersson、Dorota Gryko

  DOI：10.1039/d4cc00828f

  日期：2024.4.18

  been often regarded as an unsuitable medium for organic reactions. We have, however, found that photochemical cyclopropanation of styrenes with diazo compounds or their precursors can be performed in micellar systems. COSMO-RS studies revealed that the reactivity correlates with the predicted critical micelle concentration (CMC), with higher CMC values delivering higher yields.

  虽然在自然界中，反应发生在水基密闭空间中，但长期以来，水通常被认为是不适合有机反应的介质。然而，我们发现苯乙烯与重氮化合物或其前体的光化学环丙烷化可以在胶束体系中进行。 COSMO-RS 研究表明，反应性与预测的临界胶束浓度 (CMC) 相关，CMC 值越高，产率越高。