acetic acid 1-pentyl-hex-5-enyl ester | 1221972-32-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid 1-pentyl-hex-5-enyl ester
• 英文别名: acetic acid 1-pentylhex-5-enyl ester；Undec-1-en-6-yl acetate；undec-1-en-6-yl acetate
• CAS: 1221972-32-2
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: QPZIUHIJHKDONZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetic acid 1-pentyl-hex-5-enyl ester 在 Hoveyda-Grubbs catalyst second generation 、 cerium(III) chloride heptahydrate 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 70.42h， 生成 (E)-tridec-3-ene-2,8-diol
  参考文献：
  名称：

  FeCl3·6H2O-catalyzed synthesis of substituted cis-2,6-tetrahydropyrans from ζ-hydroxy allylic derivatives

  摘要：

  A highly diastereoselective iron-catalyzed synthesis of substituted cis-2,6-tetrahydropyrans from zeta-hydroxy allylic derivatives is described. The FeCl3 center dot 6H(2)O-induced epimerization of the formed 2-alkenyl 6-substituted tetrahydropyrans is the key reaction to account for the high diastereoselectivities observed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.112
• 作为产物：
  描述：

  5-己烯醛 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 acetic acid 1-pentyl-hex-5-enyl ester
  参考文献：
  名称：

  FeCl3·6H2O-catalyzed synthesis of substituted cis-2,6-tetrahydropyrans from ζ-hydroxy allylic derivatives

  摘要：

  A highly diastereoselective iron-catalyzed synthesis of substituted cis-2,6-tetrahydropyrans from zeta-hydroxy allylic derivatives is described. The FeCl3 center dot 6H(2)O-induced epimerization of the formed 2-alkenyl 6-substituted tetrahydropyrans is the key reaction to account for the high diastereoselectivities observed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.112

文献信息

• 茑萝属植物来源新化合物及包含其为有效成分的糖尿病的预防或治疗用组合物
  申请人：韩国生命工学研究院

  公开号：CN105473565A

  公开（公告）日：2016-04-06

  本发明提供从茑萝属植物分离的新化合物及将其作为有效成分并以化学合成方式制备从茑萝属植物分离的新化合物的方法，本发明涉及这些新化合物和包含其作为有效成分的用于预防或治疗糖尿病及糖尿病并发症的组合物，本发明的来源于茑萝属植物的新化合物及包含其为有效成分的组合物具有优秀的促进胰岛素分泌效果，可对糖尿病及由此引起的各种并发症的预防或治疗有效。
• NOVEL COMPOUND DERIVED FROM PLANT OF GENUS QUAMOCLIT AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES
  申请人：KOREA RESEARCH INSTITUTE BIOSCIENCE

  公开号：US20160130293A1

  公开（公告）日：2016-05-12

  The present invention provides a novel compound isolated from a plant of the genus Quamoclit and a method for preparing a novel compound isolated from a plant of the genus Quamoclit through chemical synthesis, and relates to a novel compound and a composition containing the novel compound as an active ingredient for preventing or treating diabetes and diabetic complications. The compound derived from a plant of the genus Quamoclit and the composition containing the compound as an active ingredient according to the present invention have an excellent effect of promoting insulin secretion, thereby exhibiting efficacies in preventing or treating diabetes and the resulting various complications.

  本发明提供了一种从牵牛属植物中分离出的新化合物，以及通过化学合成制备从牵牛属植物中分离出的新化合物的方法，并涉及一种新化合物和含有该新化合物作为活性成分的组合物，用于预防或治疗糖尿病和糖尿病并发症。根据本发明从牵牛属植物中衍生的化合物和含有该化合物作为活性成分的组合物具有促进胰岛素分泌的优异效果，从而在预防或治疗糖尿病及其相关并发症方面表现出疗效。
• FeCl₃-Catalyzed Highly Diastereoselective Synthesis of Substituted Piperidines and Tetrahydropyrans
  作者：Amandine Guérinot、Anna Serra-Muns、Christian Gnamm、Charlélie Bensoussan、Sébastien Reymond、Janine Cossy

  DOI：10.1021/ol100422d

  日期：2010.4.16

  The eco-friendly and highly diastereoselective synthesis of substituted cis-2,6-piperidines and cis-2,6-tetrahydropyrans is described. The key step of this method is the iron-catalyzed thermodynamic equilibration of 2-alkenyl 6-substituted piperidines and 2-alkenyl 6-substituted tetrahydropyrans allowing the isolation of enriched mixtures of the most stable cis-isomers.
• [EN] NOVEL COMPOUND DERIVED FROM PLANT OF GENUS QUAMOCLIT AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES<br/>[FR] NOUVEAU COMPOSÉ DÉRIVÉ D'UNE PLANTE DU GENRE QUAMOCLIT ET COMPOSITION LE CONTENANT COMME PRINCIPE ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT DU DIABÈTE
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2014189347A1

  公开（公告）日：2014-11-27

  본 발명은 유홍초속 식물에서 분리한 신규 화합물 및 이를 유효성분과 유홍초속 식물에서 분리한 신규 화합물을 화학적 합성으로 제조한 방법을 제공하고 이들 신규 화합물과 이를 유효성분으로 포함하는 당뇨병 및 당뇨합병증의 예방 또는 치료용 조성물과 관한 것으로서, 본 발명에 따른 유홍초속 식물 유래 화합물 및 이를 유효성분으로 포함하는 조성물은 우수한 인슐린 분비 촉진 효과를 가지고 있어, 당뇨병 및 이로 인한 각종 합병증의 예방 또는 치료에 효능을 나타낼 수 있다.