2-Brom-1-(4-isopropoxyphenyl)-1-propanon | 35133-38-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Brom-1-(4-isopropoxyphenyl)-1-propanon
• 英文别名: 2-Bromo-4'-isopropoxypropiophenone；2-Bromo-1-(4-propan-2-yloxyphenyl)propan-1-one
• CAS: 35133-38-1
• 化学式: C₁₂H₁₅BrO₂
• 分子量: 271.154
• InChiKey: DMPURYNRSCYBFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-十八碳烯-1-胺 、 2-Brom-1-(4-isopropoxyphenyl)-1-propanon 生成
  参考文献：
  名称：

  DE2817494

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(4-异丙氧基苯基)-1-丙酮 在 溴 作用下， 生成 2-Brom-1-(4-isopropoxyphenyl)-1-propanon
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064

文献信息

• PYRROLE DERIVATIVES AND MEDICINAL COMPOSITION
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0842923A1

  公开（公告）日：1998-05-20

  The invention relates to a pharmaceutical composition comprising a pyrrole derivative of the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate of either of them, as an active ingredient. (wherein R1 represents hydrogen or alkoxycarbonylamino, R2 represents alkyl, aryl which may be substituted, aromatic heterocyclyl which may be substituted, unsubstituted amino, monoalkylamino, dialkylamino, or cyclic amino which may be substituted; R3 represents cyano or carbamoyl; R4 represents hydrogen or alkyl; E represents alkylene; q is equal to 0 or 1, A represents methyl, aryl which may be substituted, or aromatic heterocyclyl which may be substituted) The pharmaceutical composition of the invention is effective for the treatment of pollakiuria or urinary incontinence.

  本发明涉及一种药物组合物，其活性成分包括下式[1]的吡咯衍生物或其药学上可接受的盐，或二者之一的溶液。 (其中 R1 代表氢或烷氧羰基氨基，R2 代表烷基、可被取代的芳基、可被取代的芳香杂环基、未取代的氨基、单烷基氨基、二烷基氨基或可被取代的环氨基；R3 代表氰基或氨基甲酰基；R4 代表氢或烷基；E 代表亚烷基；q 等于 0 或 1，A 代表甲基、可被取代的芳基或可被取代的芳香杂环基)。 本发明的药物组合物对治疗花粉尿症或尿失禁有效。
• US4474977A
  申请人：——

  公开号：US4474977A

  公开（公告）日：1984-10-02
• US5998459A
  申请人：——

  公开号：US5998459A

  公开（公告）日：1999-12-07
• US6172102B1
  申请人：——

  公开号：US6172102B1

  公开（公告）日：2001-01-09
• 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
  作者：Kazutoshi Watanabe、Yasuhiro Morinaka、Yoshio Hayashi、Masaki Shinoda、Hiroyoshi Nishi、Nobuko Fukushima、Toshiaki Watanabe、Akira Ishibashi、Satoshi Yuki、Masahiko Tanaka

  DOI：10.1016/j.bmcl.2007.12.064

  日期：2008.2

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.