1-(4-甲氧基苯基)-2-丁醇 | 110661-90-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(4-甲氧基苯基)-2-丁醇
• 英文名称: 1-(4-methoxyphenyl)-2-butanol
• 英文别名: 1-(4-methoxyphenyl)butan-2-ol；1-(4-methoxy-phenyl)-butan-2-ol；(+/-)-4-Methoxy-1-(2-hydroxy-butyl)-benzol
• CAS: 110661-90-0
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: ARRSWKWGQREELC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基苯基)-2-丁醇 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以78.8%的产率得到1-(4-甲氧基苯基)-2-丁酮
  参考文献：
  名称：

  WO2007/102679

  摘要：

  公开号：
• 作为产物：
  描述：

  对甲氧基苯乙醇 在 pyridine-SO3 complex 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 12.0h， 生成 1-(4-甲氧基苯基)-2-丁醇
  参考文献：
  名称：

  WO2007/102679

  摘要：

  公开号：

文献信息

• New organocopper reagents prepared utilizing highly reactive copper
  作者：Reuben D. Rieke、Richard M. Wehmeyer、Tse-Chong Wu、Greg W. Ebert

  DOI：10.1016/0040-4020(89)80072-9

  日期：1989.1

  Highly reactive copper solutions have been prepared by the lithium naphthalide reduction of copper(I) iodide/trialkylphosphine complexes. These activated copper solutions will react with organic halides under very mild conditions to form stable organocopper reagents. Significantly, the organocopper reagents can contain considerable functionalities such as ester, nitrile, chloride, epoxide, and ketone

  通过碘化亚铜（I）/三烷基膦配合物的萘锂制备了高反应性的铜溶液。这些活化的铜溶液将在非常温和的条件下与有机卤化物反应，形成稳定的有机铜试剂。重要的是，有机铜试剂可以包含大量的官能团，例如酯，腈，氯，环氧基和酮基。这些官能化的有机铜物质经历许多其他有机铜物质典型的反应。已经成功实现了分子间的1,4-加成，环氧化物开放反应以及与酰氯的酮形成。另外，该方法已经应用于分子内环氧化物裂解反应。连接链长度，取代方式，反应溶剂，
• Direct and Unified Access to Carbon Radicals from Aliphatic Alcohols by Cost‐Efficient Titanium‐Mediated Homolytic C−OH Bond Cleavage
  作者：Takuya Suga、Yuuki Takahashi、Chinatsu Miki、Yutaka Ukaji

  DOI：10.1002/anie.202112533

  日期：2022.3

  combination of “TiCl2(cat)” and Zn (cat=catecholate) facilitates the homolytic cleavage of “non-activated” alcohol C−O bonds. All aliphatic primary, secondary and tertiary alcohols serve as good substrates. This method was applied to radical conjugate addition reactions successfully, and mechanistic studies indicate that alkyl chlorides are not intermediates. The active species is a 1 : 2 complex of alkoxide

  “TiCl 2 (cat)”和 Zn (cat=儿茶酚酸盐) 的组合促进了“未活化”醇 C-O 键的均裂。所有脂肪族伯醇、仲醇和叔醇都可作为良好的底物。该方法成功地应用于自由基共轭加成反应，机理研究表明烷基氯化物不是中间体。活性物质是醇盐和 Ti III的 1:2 络合物。
• Sosa, Annales de Chimie (Cachan, France), 1940, vol. <11> 14, p. 5,54
  作者：Sosa

  DOI：——

  日期：——
• Direct formation and reaction of thienyl-based organocopper reagents
  作者：Reuben D. Rieke、Walter R. Klein、Tse Chong Wu

  DOI：10.1021/jo00061a024

  日期：1993.4

  The preparation of a highly reactive zerovalent copper complex by the direct reduction of lithium (2-thienylcyano)cuprate with preformed lithium naphthalenide is described. This active copper species oxidatively adds to carbon-halogen bonds to form organocopper reagents. The ability to directly form the organocopper reagent from organic halides and active copper allows for the incorporation of a wide variety of functionalities to be present in the organic halides and the organocopper reagents. Significantly, this formulation of active copper was able to oxidatively add to allyl chlorides and acetates at low temperatures to allow the direct formation of allylic organocopper reagents without Wurtz-type homocoupling. These functionalized organocopper compounds are able to undergo a variety of reactions, such as cross-coupling with acid chlorides, 1,4-conjugate addition with alpha,beta-unsaturated carbonyl compounds, and intermolecular and intramolecular epoxide-opening reactions. Subsequently, this copper species avoids the use of phosphine ligands affording the product isolation much more convenient than with phosphine-based organocopper reagents.
• Rieke, Reuben D.; Wu, Tse-Chong; Stinn, Dean E., Synthetic Communications, 1989, vol. 19, # 11-12, p. 1833 - 1840
  作者：Rieke, Reuben D.、Wu, Tse-Chong、Stinn, Dean E.、Wehmeyer, Richard M.

  DOI：——

  日期：——