5-bromo-1-pentanesulfonic acid sodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 5-bromo-1-pentanesulfonic acid sodium salt
• 英文别名: sodium 5-bromopentane sulfonate；sodium 5-bromopentanesulfonate；sodium;5-bromopentane-1-sulfonate
• 化学式: C₅H₁₀BrO₃S*Na
• 分子量: 253.092
• InChiKey: RYTRESGBLJPGDE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromo-1-pentanesulfonic acid sodium salt 在 N,N-二甲基甲酰胺 氯化亚砜 、 氨 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 4.5h， 以16%的产率得到5-bromopentane-1-sulfonamide
  参考文献：
  名称：

  [EN] NOVEL IMIDAZOLIDINE DERIVATIVES
  [FR] NOUVEAUX DÉRIVÉS IMIDAZOLIDINE

  摘要：

  通式（I）代表的化合物；以及含有这些化合物的药物和药用组合物：（I）中n是1到20的整数；Q是（II）或（III）A是氰基或类似物；B是氢、卤素或类似物；X1和X2分别独立地从O和S之间选择；E是C1-4烷基；R1、R2、R3和R4分别独立地从氢和C1-6烷基之间选择。

  公开号：

  WO2006013887A1
• 作为产物：
  描述：

  1,5-二溴戊烷 在 sodium sulfite 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 5-bromo-1-pentanesulfonic acid sodium salt
  参考文献：
  名称：

  [EN] NOVEL IMIDAZOLIDINE DERIVATIVES
  [FR] NOUVEAUX DÉRIVÉS IMIDAZOLIDINE

  摘要：

  通式（I）代表的化合物；以及含有这些化合物的药物和药用组合物：（I）中n是1到20的整数；Q是（II）或（III）A是氰基或类似物；B是氢、卤素或类似物；X1和X2分别独立地从O和S之间选择；E是C1-4烷基；R1、R2、R3和R4分别独立地从氢和C1-6烷基之间选择。

  公开号：

  WO2006013887A1

文献信息

• Naphthocyanines for Use as Contrast Agents
  申请人：Langhals Heinz

  公开号：US20130131354A1

  公开（公告）日：2013-05-23

  Cyanine dyes having optional sulfonic acid substituents on the aromatic nucleus have been developed for use as contrast agents for assisting in surgery and diagnosis, especially for simplifying the surgical removal of basal membranes of the eye, such as the internal limiting membrane (ILM), and for dyeing the lens capsule.

  在芳香核上具有可选磺酸取代基团的青霉素染料已经被开发用作手术和诊断辅助对比剂，特别是为了简化眼睛基底膜的手术切除，例如内限膜（ILM），以及染色晶状体囊。
• Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
  申请人：——

  公开号：US20030176486A1

  公开（公告）日：2003-09-18

  The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

  本发明涉及一种新型的羟肟酸磺酸衍生物或其药理学上可接受的盐。更具体地说，本发明涉及一种羟肟酸磺酸衍生物或其药理学上可接受的盐，其用作脂多糖（LPS）抑制剂。此外，本发明涉及一种新型中间体化合物，可用于合成此羟肟酸磺酸衍生物。
• Stable conducting polymer and processes for the preparation thereof
  申请人：Korea Research Institute of Chemical Technology

  公开号：US05500474A1

  公开（公告）日：1996-03-19

  Conductive polymers having repeating units of formula (II) ##STR1## formed by chemical or electrochemical oxidation of aniline derivatives of formula (I) ##STR2## wherein R.sub.1 denotes --(CH.sub.2).sub.n --; n is an integer between 2 and 12; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 denote hydrogens or one or two of them can be a halogen atom, methyl, methoxy or nitro groups; and X denotes hydrogen an alkali metal ion, an ammonium ion, an alkyl ammonium ion or an anilinium ion. The conductive polymers have excellent stability toward electrochemical redox cyclization and good processibility.

  具有重复单元式（II）的导电聚合物 ##STR1## 由公式（I）的苯胺衍生物的化学或电化学氧化形成，其中R.sub.1表示--（CH.sub.2）.sub.n--；n是介于2和12之间的整数；R.sub.2、R.sub.3、R.sub.4和R.sub.5表示氢原子，其中一个或两个可以是卤素原子、甲基、甲氧基或硝基基团；X表示氢原子、碱金属离子、铵离子、烷基铵离子或苯胺铵离子。这些导电聚合物具有优异的电化学氧化还原循环稳定性和良好的可加工性。
• Naphthocyanines for use as contrast agents
  申请人：Langhals Heinz

  公开号：US08835484B2

  公开（公告）日：2014-09-16

  Cyanine dyes having optional sulfonic acid substituents on the aromatic nucleus have been developed for use as contrast agents for assisting in surgery and diagnosis, especially for simplifying the surgical removal of basal membranes of the eye, such as the internal limiting membrane (ILM), and for dyeing the lens capsule.

  含有芳香核上可选磺酸取代基的青霉素染料已被开发用作辅助手术和诊断的对比剂，特别是用于简化眼睛的基底膜（如内限膜（ILM））的手术切除，并用于染色晶状体囊袋。
• Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery
  作者：Heinz Langhals、Ana Varja、Peter Laubichler、Marcus Kernt、Kirsten Eibl、Christos Haritoglou

  DOI：10.1021/jm2001986

  日期：2011.6.9

  Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.