3-(2-phenylphenyl)pyridine | 911497-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-phenylphenyl)pyridine
• 英文别名: 3-(2-biphenyl)pyridine；3-([1,1'-Biphenyl]-2-yl)pyridine
• CAS: 911497-13-7
• 化学式: C₁₇H₁₃N
• 分子量: 231.297
• InChiKey: DHZYSVAMXLLIEX-UHFFFAOYSA-N

物化性质

• 沸点：
  357.9±11.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(2-phenylphenyl)pyridine 、 vinylidene-1,1-diphosphonic acid 以 水 为溶剂， 反应 2.0h， 以48%的产率得到Hydroxy-[2-[3-(2-phenylphenyl)pyridin-1-ium-1-yl]-1-phosphonoethyl]phosphinate
  参考文献：
  名称：

  Activity of Nitrogen-Containing and Non-Nitrogen-Containing Bisphosphonates on Tumor Cell Lines

  摘要：

  We synthesized and tested three series of bisphosphonates for their activity in inhibiting the growth of three human tumor cell lines: MCF-7 (breast), NCI-H460 (lung), and SF-268 (CNS). The first series of compounds consisted of 49 nitrogen-containing bisphosphonates, the most active species being a tetrakispivaloyloxymethyl (POM) ester, having an (average) IC50 of 6.8 mu M. The second series of compounds consisted of nine terphenylbisphosphonates, the most active species also being a POM ester, having an IC50 of 2.2 mu M. The third series of compounds consisted of seven halogen or cyanophenylbisphosphonates, the most active species again being a POM ester, having an IC50 of 500 nM. Taken together, these results are of interest because they show that bisphosphonate esters can have potent activity against a variety of tumor cell lines, with the most active terphenyl-and halophenyl-containing species having IC50 values similar to 10-40x lower than the most potent commercially available bisphosphonates.

  DOI：

  10.1021/jm060280e
• 作为产物：
  描述：

  3-溴吡啶 、 2-联苯硼酸 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 72.08h， 以80.6%的产率得到3-(2-phenylphenyl)pyridine
  参考文献：
  名称：

  Light Emitting Compound for Electroluminescent Applications

  摘要：

  本发明涉及发光化合物，特别是用于电致发光应用的磷光化合物，例如在OLED和激光应用中形成未掺杂的层，当通过电流激发时发射可见光。本发明的化合物包括一个核结构，符合通式(I)，其中Met=Ir、Pt、Pd、Ru、Rh、Re或Os，n=1-3，m=对于Ir、Ru、Rh、Re或Os为3-n，对于Pt或Pd为1或2，m=2-n，其中r和s分别是独立的正自然数，最好变化不超过2，更好地相同，其中组U和V可以独立选择自化学键，任何取代或未取代的芳香或非芳香多环或单环基团，烷基，双键，三键，氮，氧，硫，硒，碲，NR，其中R从氢，烷基，芳基或杂环烃中选择，Ar3是一个允许与U和V基团形成化学键的芳香或非芳香基团，分别来自于包含在基团Ar3，A1中的相邻原子，通式(II)是一个饱和配体。

  公开号：

  US20080194821A1

文献信息

• LIGHT EMITTING COMPOUND FOR ELECTROLUMINESCENT APPLICATIONS
  申请人：Technische Universität Braunschweig

  公开号：EP1883687A1

  公开（公告）日：2008-02-06
• US7045532B2
  申请人：——

  公开号：US7045532B2

  公开（公告）日：2006-05-16
• [EN] LIGHT EMITTING COMPOUND FOR ELECTROLUMINESCENT APPLICATIONS<br/>[FR] COMPOSE LUMINESCENT POUR APPLICATIONS ELECTROLUMINESCENTES
  申请人：UNIV BRAUNSCHWEIG TECH

  公开号：WO2006119800A1

  公开（公告）日：2006-11-16

  [EN] The present invention refers to light emitting compounds, especially to phosphorescent compounds useful for electroluminescent applications, for example forming a layer in OLEDs and laser applications to emit visible light when excited by electric current. The compounds of the present invention comprise a core structure according to general formula (I), wherein Met = Ir, Pt, Pd, Ru, Rh, Re, or Os with n =1-3, m = 3-n for Ir, Ru, Rh, Re or Os and with n = l or 2, m = 2-n for Pt or Pd, wherein r and s are independently positive natural numbers, preferably varying by a maximum of 2, more preferably identical, wherein groups U and V can be selected independently from a chemical bond, any substituted or unsubstituted aromatic or non-aromatic poly- or mono-cyclic group, alkyl, a double bond, a triple bond, nitrogen, oxygen, sulfur, selenium, telluride, NR with R selected from hydrogen, alkyl, aryl or heteroaryl, wherein Ar3 is an aromatic or non-aromatic moiety which allows the formation of chemical bonds to groups U and V, respectively, from neighbouring atoms contained in moiety Ar3, A1 and wherein formula (II) is a saturating ligand.
  [FR] L'invention concerne des composés luminescents, en particulier, des composés phosphorescents utiles pour des applications électroluminescentes, par exemple, la création d'une couche dans des diodes (OLED) et des applications laser afin d'émettre de la lumière visible quand ils sont excités par le courant électrique. Ces composés comprennent une structure de noyau représentée par la formule suivante (I), dans laquelle Met: Ir, Pt, Pd, Ru, Rh, Re ou Os, n=1-3, m=3-n pour Ir, Ru, Rh, Re ou Os, n=1 ou 2 et m=2-n pour Pt ou Pd, r et s étant indépendamment des nombres naturels positifs, variant de préférence selon un maximum de 2, encore de préférence identiques, les groupes U et V pouvant être sélectionnés indépendamment dans une liaison chimique, tout groupe aromatique substitué ou non substitué ou non aromatique, poly- ou monocyclique, une liaison double, une liaison triple, azote, oxygène, soufre, sélénium, tellurure, NR dans laquelle R est sélectionné dans hydrogène, alkyle, aryle ou hétéroaryle, Ar3 représentant une fraction aromatique ou non aromatique permettant à des liaisons chimiques de se créer avec les groupes U et V respectifs, à partir des atomes avoisinant contenus dans cette fraction Ar3, A1 et dans laquelle la formule (II) représente un ligand de saturation.
• Activity of Nitrogen-Containing and Non-Nitrogen-Containing Bisphosphonates on Tumor Cell Lines
  作者：Yonghui Zhang、Annette Leon、Yongcheng Song、Danielle Studer、Christa Haase、Lukasz A. Koscielski、Eric Oldfield

  DOI：10.1021/jm060280e

  日期：2006.9.1

  We synthesized and tested three series of bisphosphonates for their activity in inhibiting the growth of three human tumor cell lines: MCF-7 (breast), NCI-H460 (lung), and SF-268 (CNS). The first series of compounds consisted of 49 nitrogen-containing bisphosphonates, the most active species being a tetrakispivaloyloxymethyl (POM) ester, having an (average) IC50 of 6.8 mu M. The second series of compounds consisted of nine terphenylbisphosphonates, the most active species also being a POM ester, having an IC50 of 2.2 mu M. The third series of compounds consisted of seven halogen or cyanophenylbisphosphonates, the most active species again being a POM ester, having an IC50 of 500 nM. Taken together, these results are of interest because they show that bisphosphonate esters can have potent activity against a variety of tumor cell lines, with the most active terphenyl-and halophenyl-containing species having IC50 values similar to 10-40x lower than the most potent commercially available bisphosphonates.
• Light Emitting Compound for Electroluminescent Applications
  申请人：Johannes Hans-Hermann

  公开号：US20080194821A1

  公开（公告）日：2008-08-14

  The present invention refers to light emitting compounds, especially to phosphorescent compounds useful for electroluminescent applications, for example forming a layer in OLEDs and laser applications undoped to emit visible light when excited by electric current. The compounds of the present invention comprise a core structure according to general formula (I), wherein Met=Ir, Pt, Pd, Ru, Rh, Re, or Os with n=1-3, m=3-n for Ir, Ru, Rh, Re or Os and with n=1 or 2, m=2-n for Pt or Pd, wherein r and s are independently positive natural numbers, preferably varying by a maximum of 2, more preferably identical, wherein groups U and V can be selected independently from a chemical bond, any substituted or unsubstituted aromatic or non-aromatic poly- or mono-cyclic group, alkyl, a double bond, a triple bond, nitrogen, oxygen, sulfur, selenium, telluride, NR with R selected from hydrogen, alkyl, aryl or heteroaryl, wherein Ar3 is an aromatic or non-aromatic moiety which allows the formation of chemical bonds to groups U and V, respectively, from neighbouring atoms contained in moiety Ar3, A1 and wherein formula (II) is a saturating ligand.

  本发明涉及发光化合物，特别是用于电致发光应用的磷光化合物，例如在OLED和激光应用中形成未掺杂的层，当通过电流激发时发射可见光。本发明的化合物包括一个核结构，符合通式(I)，其中Met=Ir、Pt、Pd、Ru、Rh、Re或Os，n=1-3，m=对于Ir、Ru、Rh、Re或Os为3-n，对于Pt或Pd为1或2，m=2-n，其中r和s分别是独立的正自然数，最好变化不超过2，更好地相同，其中组U和V可以独立选择自化学键，任何取代或未取代的芳香或非芳香多环或单环基团，烷基，双键，三键，氮，氧，硫，硒，碲，NR，其中R从氢，烷基，芳基或杂环烃中选择，Ar3是一个允许与U和V基团形成化学键的芳香或非芳香基团，分别来自于包含在基团Ar3，A1中的相邻原子，通式(II)是一个饱和配体。