2-(1-acetoxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 2-(1-acetoxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione
• 英文别名: 1-(4,9-dioxobenzo[f][1]benzofuran-2-yl)ethyl acetate
• 化学式: C₁₆H₁₂O₅
• 分子量: 284.268
• InChiKey: ADEKBIWUKGUNEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(1-acetoxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以35%的产率得到2-(1-hydroxy-ethyl)-naphtho[2,3-b]furan-4,9-dione
  参考文献：
  名称：

  JP2015/34179

  摘要：

  公开号：
• 作为产物：
  描述：

  3-[(E)-but-1-enyl]-4-hydroxynaphthalene-1,2-dione 在 N-溴代丁二酰亚胺(NBS) 、 mercury(II) diacetate 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 27.0h， 生成 2-(1-acetoxyethyl)-4H,9H-naphtho[2,3-b]furan-4,9-dione
  参考文献：
  名称：

  JP2015/34179

  摘要：

  公开号：

文献信息

• NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS
  申请人：Jiang Zhiwei

  公开号：US20110112180A1

  公开（公告）日：2011-05-12

  The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

  本发明涉及一种新型的萘类化合物，作为Stat3通路抑制剂和癌症干细胞抑制剂；以及使用这些化合物治疗癌症的方法；以及使用这些化合物治疗与哺乳动物中异常Stat3通路活性相关的疾病的方法；以及含有这些化合物的药物组合物。
• Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US10738023B2

  公开（公告）日：2020-08-11

  Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.

  本发明提供了一种生产 2-烷基羰基萘并[2,3-b]呋喃-4,9-二酮相关物质的方法，该方法适于工业化生产。本发明提供了：一种生产 2-烷基羰基[2,3-b]呋喃-4,9-二酮的中间体的方法，该方法包括在金属或金属化合物和碱存在下，在溶剂中使酮或醇被保护的 1-丁炔衍生物与位置-3 上有离去基团的 2-羟基-1,4-萘醌衍生物反应；以及一种与该中间体有关的物质。
• Stat3 pathway inhibitors and cancer stem cell inhibitors
  申请人：Sumitomo Dainippon Pharma Oncology, Inc.

  公开号：US10851075B2

  公开（公告）日：2020-12-01

  The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

  本发明涉及作为Stat3通路抑制剂和癌症干细胞抑制剂的一类新型萘化合物；涉及使用此类化合物治疗癌症的方法；涉及使用此类化合物治疗哺乳动物体内与Stat3通路活性异常有关的疾病的方法；涉及含有此类化合物的药物组合物。
• METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US20200239424A1

  公开（公告）日：2020-07-30

  Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.
• US8877803B2
  申请人：——

  公开号：US8877803B2

  公开（公告）日：2014-11-04