苯并[g][1]苯并呋喃-2-甲醛 | 103997-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 中文名称: 苯并[g][1]苯并呋喃-2-甲醛
• 英文名称: naphtho[1,2-b]furan-2-carboxaldehyde
• 英文别名: naphtho[1,2-b]furan-2-carbaldehyde；Naptho[1,2-b]furan-2-carbaldehyde；benzo[g][1]benzofuran-2-carbaldehyde
• CAS: 103997-05-3
• 化学式: C₁₃H₈O₂
• 分子量: 196.205
• InChiKey: HSINFBUEWVXJAN-UHFFFAOYSA-N

物化性质

• 沸点：
  366.0±15.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯并[g][1]苯并呋喃-2-甲醛 以43.4%的产率得到2-Methyl-2-[(naphtho[1,2-b]furan-2-ylmethyl)amino]-1,3-propanediol hydrochloride
  参考文献：
  名称：

  Polycyclic compounds, their preparation and use and formulations containing them

  摘要：

  公开号：

  EP0183439B1
• 作为产物：
  描述：

  naphtho[1,2-b]furan-2-methanol 以84%的产率得到
  参考文献：
  名称：

  BAIR, KENNETH W.

  摘要：

  DOI：

文献信息

• Certain substituted naphthofurans with anti-tumor properties
  申请人：Burroughs Wellcome Co.

  公开号：US05008286A1

  公开（公告）日：1991-04-16

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acide addition salts thereof; wherein Ar is a fused tricyclic aromatic ring system containing a maximum of 14 ring atoms and at least one heteroatom or a fused pentacyclic ring system with at least 4 aromatic rings containing a maximum of 22 ring atoms and at least one heteroatom; or a substituted derivative thereof; for either the tricyclic or pentacyclic ring system there is a maximum of one heteroatom for each ring present but preferably only one or two of the rings contain a heteroatom; the rings forming the tricyclic or the pentacyclic ring system contain five or six atoms; the heteroatoms are conveniently nitrogen, phosphorus, oxygen, sulfur or selenium; suitably the heteroatom is oxygen, sulfur or nitrogen; the tricyclic or the pentacyclic ring system should be planar or deviate only slightly from planarity; suitably the ring system is aromatic or contains one non-aromatic ring; preferably the ring system is aromatic; nitrogen atoms contained in five-membered rings are substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl. The compounds have biocidal properties.

  本发明涉及化合物的公式（I）ArCH.sub.2 R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；酸盐；其中Ar是含有最多14个环原子和至少一个杂原子的融合三环芳香环系统或至少4个芳香环的含有最多22个环原子和至少一个杂原子的融合五环系统；或其取代衍生物；对于三环或五环系统，每个环最多有一个杂原子，但最好只有一个或两个环含有杂原子；形成三环或五环系统的环包含五个或六个原子；杂原子方便地是氮、磷、氧、硫或硒；适宜的杂原子是氧、硫或氮；三环或五环系统应该是平面的或仅略微偏离平面；合适的环系统是芳香的或包含一个非芳香环；最好环系统是芳香的；五元环中含氮原子被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个基团##STR1##其中m为0或1；R.sup.5是氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10是氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14是氢、甲基、羟基或羟甲基。这些化合物具有杀生物性能。
• Synthesis and Photochemistry of Styryl Substituted Annelated Furan Derivatives
  作者：Marija Sindler-Kulyk、Irena Skoric、Slavica Tomsic、Zeljko Marinic、Draginja Mrvos-Sermek

  DOI：10.3987/com-99-8502

  日期：——

  New beta-substituted benzo- and naphthofuryl derivatives (5, 6 and 7) of o-divinylbenzene, were synthesized and irradiated in order to form annelated bicyclo[3.2.1]octadienes. While 2-[2-(2-vinylphenyl)ethenyl]benzo[b]furan (5) upon irradiation gives the bicyclo[3.2.1]octadiene derivative (12) in 65% yield, 2-[2-(2-vinylphenyl) ethenyl]naphtho[2,1-b]furan (6) and 2-[2-(2-vinylphenyl)ethenyl]naphtho[1,2-b]furan (7), undergo cis-trans-isomerization but not form intramolecular photocycloaddition products. The mechanism of the intramolecular [2+2] photocycloaddition is explained via intermediate (17) which was proved by the formation of products (18) and (19), by irradiation in methanol and deuteromethanol.
• BAIR, KENNETH W.
  作者：BAIR, KENNETH W.

  DOI：——

  日期：——
• US3932301A
  申请人：——

  公开号：US3932301A

  公开（公告）日：1976-01-13
• US3993645A
  申请人：——

  公开号：US3993645A

  公开（公告）日：1976-11-23