6-methyl-7-oxooctanoic acid | 99183-34-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-methyl-7-oxooctanoic acid
• 英文别名: 6-Methyl-7-oxooctanoic acid
• CAS: 99183-34-3
• 化学式: C₉H₁₆O₃
• mdl: MFCD20639044
• 分子量: 172.224
• InChiKey: WFGUTPGXNJPFOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 储存条件：
  存储条件：2-8°C，干燥

制备方法与用途

6-甲基-7-氧代辛酸用于作为研究用途的化合物。

反应信息

• 作为反应物：
  描述：

  6-methyl-7-oxooctanoic acid 、 苯肼 在 溶剂黄146 作用下， 反应 3.5h， 以78%的产率得到5-(2,3-dimethyl-3H-indol-3-yl)pentanoic acid
  参考文献：
  名称：

  Water-soluble cyanine dyes for biological microchip technology

  摘要：

  新型吲哚二碳菁染料被合成，并测定了它们的谱学特性。对于等浓度的染料，在激发波长 λ = 635 nm 和 655 nm，以及发射波长 λ = 670 nm 和 690 nm 处，分别测量了相对荧光效率。

  DOI：

  10.1007/s11172-007-0387-3
• 作为产物：
  描述：

  rac-methyl 6-methyl-7-oxooctanoate 在 盐酸 、 水 作用下， 反应 6.0h， 以75%的产率得到6-methyl-7-oxooctanoic acid
  参考文献：
  名称：

  Synthesis of carboxyalkylindolenines from 6-methyl-7-oxooctanoic acid

  摘要：

  获得了新型3-(4-羧基丁基)吲哚啉。开发了一种合成6-甲基-7-氧代辛酸的方法，该酸是这些吲哚啉的前体。

  DOI：

  10.1007/s11172-008-0095-7

文献信息

• New indodicarbocyanine dyes for the biological microchip technology
  作者：V. E. Kuznetsova、V. A. Vasiliskov、O. V. Antonova、V. M. Mikhailovich、A. S. Zasedatelev、A. V. Chudinov

  DOI：10.1134/s1068162008010184

  日期：2008.1

  New indodicarbocyanine dyes with the carboxybutyl group in position-3 of the indolenine fragment bearing methyl and sulfonic groups in positions 5 and 7 of the cycle were synthesized in order to find the most effective fluorescent labels for the biological microchip technology. The position of absorption and fluorescence maxima, the total charge of the dye molecule, and water solubility depend on the location and the total amount of methyl and sulfonic groups. The spectral characteristics of the dyes synthesized were determined. The relative fluorescence efficiencies of the dyes at equal concentrations were measured at excitation wavelengths of 635 and 655 nm and emission wavelengths of 670 and 690 nm, respectively.

  为寻找生物微芯片技术中最有效的荧光标记物，合成了吲哚碳菁染料，其吲哚啉部分的3位带有羧丁基，环的5位和7位分别带有甲基和磺酸基。染料的吸收和荧光最大值位置、分子总电荷以及水溶性取决于甲基和磺酸基的位置和总量。测定了所合成染料的光谱特性，并在激发波长为635nm和655nm，发射波长为670nm和690nm时，分别测量了等浓度染料的相对荧光效率。
• WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS
  申请人：COOPER EDWARD MICHAEL

  公开号：US20060239922A1

  公开（公告）日：2006-10-26

  Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 R 11 , R 12 , R 13 and R 14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 comprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.

  揭示了一种对于标记和检测生物和其他材料有用的青霉素染料。该染料的化学式为（I）：其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13和R14中的至少一个是-L-M或-L-P，其中L是连接基团，M是目标键合基团，P是共轭组分，并且R3、R4、R5、R6、R7、R8、R9和R10中的至少一个包含氟。通过用氟取代并具有三个或更多磺酸基团的青霉素染料标记生物靶分子，得到的标记产品中减少了染料-染料聚集并提高了光稳定性，与没有这种取代的青霉素染料相比。本发明的染料在涉及荧光检测的分析中特别有用，其中需要连续或重复激发，例如在动力学研究中，或在微阵列分析中，微阵列玻片可能需要在数天内重新分析。
• INDICYANINE DYES AND THE DERIVATIVES THEREOF FOR ANALYSING BIOLOGICAL MICROMOLECULES
  申请人：UCHREZHDENIE ROSSIISKOI AKADEMII NAUK INSTITUT MOLEKULYARNOI BIOLOGII IM. V.A. ENGELGARDTA RAN (IMB RAN)

  公开号：EP2157088A1

  公开（公告）日：2010-02-24

  The invention relates to two series of synthesised indolenine pentamethine dyes (37 compounds) comprising a reactive group in the third and fifth positions of the indolenine cycle, respectively. A method for producing, extracting and purifying the dyes and the precursors thereof, consisting in determining the absorption and fluorescence maxima, molecular extinction factors, fluorescence quantum yields, relative fluorescence effectiveness at excitation on a wavelength of 635 nm (detection of 670 nm) and 655 nm (detection of 690 nm), relative light stability and comparative sensitivity of detection of marked oligonucleotides on biochips of the claimed dyes, is disclosed. The use of the claimed dyes in the form of fluorescent marks for oligonucleotide and protein chips is also disclosed.

  本发明涉及两个系列的合成吲哚啉五甲胺染料（37 种化合物），它们分别在吲哚啉循环的第 3 位和第 5 位含有一个活性基团。本发明公开了一种生产、提取和纯化这些染料及其前体的方法，包括确定所称染料的吸收和荧光最大值、分子消光系数、荧光量子产率、在 635 纳米波长（检测 670 纳米波长）和 655 纳米波长（检测 690 纳米波长）激发下的相对荧光效力、相对光稳定性以及在生物芯片上检测标记寡核苷酸的比较灵敏度。还公开了所要求的染料以荧光标记的形式用于寡核苷酸和蛋白质芯片。
• Indolium compounds containing fluoro-substituents
  申请人：GE Healthcare UK Limited

  公开号：EP2270106A2

  公开（公告）日：2011-01-05

  Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R12, R13 and R14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R3, R4, R5, R6, R7, R8, R9 and R10 comprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.

  所公开的氰基染料可用于标记和检测生物材料和其他材料。这些染料为式 (I)： 其中基团 R1、R2、R3、R4、R5、R6、R7、R8、R9、R10 R11、R12、R13 和 R14 中至少有一个是-L-M 或-L-P，其中 L 是连接基团，M 是目标键合基团，P 是共轭组分，基团 R3、R4、R5、R6、R7、R8、R9 和 R10 中至少有一个包含氟。使用被氟取代并另外被三个或更多磺酸基团取代的氰基染料标记生物目标分子，与没有此类取代的氰基染料相比，标记产品中的染料聚集减少，光稳定性提高。本发明的染料在需要持续或重复激发的荧光检测中特别有用，例如在动力学研究中，或在微阵列分析中，微阵列切片可能需要在几天内重新分析。
• EP2157088
  申请人：——

  公开号：——

  公开（公告）日：——