N,N'-bis(4-chlorobutyryl)cystamine | 223710-73-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-bis(4-chlorobutyryl)cystamine
• 英文别名: N,N'-(disulfanediyldiethane-2,1-diyl)bis(4-chlorobutanamide)；4-chloro-N-[2-[2-(4-chlorobutanoylamino)ethyldisulfanyl]ethyl]butanamide
• CAS: 223710-73-4
• 化学式: C₁₂H₂₂Cl₂N₂O₂S₂
• 分子量: 361.357
• InChiKey: NEEMTXNSVJGIHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-bis(4-chlorobutyryl)cystamine 在 四氢吡咯 、 溶剂黄146 作用下， 以 2-甲基-2-丁醇 、 乙醇 为溶剂， 反应 32.5h， 生成 4-[4-[(E)-2-[4-[2-cyanoethyl(methyl)amino]phenyl]vinyl]pyridine-1-ium-1-yl]-N-[2-[2-[4-[4-[(E)-2-[4-[2-cyanoethyl(methyl)amino]phenyl]vinyl]pyridine-1-ium-1-yl]butanoylamino]ethyl-disulfanyl]ethyl]butanamide dichloride
  参考文献：
  名称：

  [EN] STYRYL SULFIDE DYES
  [FR] COLORANTS DE SULFURE DE STYRYLE

  摘要：

  揭示了式（1）的苯基染料，其中R1、R2、R3、R'1、R'2和R'3彼此独立地为氢；-NH（CO）-C1-C5烷基；-N（C1-C5烷基）（C1-C5烷基-CN）；C1-C6烷氧基；一个杂环基；或者R1和R2或R'1和R'2一起形成一个5到10个成员的、单环的、碳环的或杂环的环；其中R1、R2、R3、R'1、R'2和R'3中至少有一个不同于氢；Q和Q'彼此独立地为直接键；*-C（O）-*；*-C（O）O-*；*-OCO-*；*-N（R4）-*；（AA）；*-C（O）N（R6）-*；或者*-(R6)NC（O）-*；而R4、R5和R6彼此独立地为氢；C1-C14烷基；C2-C14烯基；C6-C12芳基；C6-C12芳基-C1-C10烷基；或者C1-C10烷基（C5-C12芳基）；X和X'为*-(CH2)m-*；Y1和Y2彼此独立地为C1-C10烷基；C5-C10环烷基；C5-C12芳基；或者C5-C12芳基-(C1-C10烷基)；An-为阴离子；m为1至8的数字；n为0或1；p为0或1。

  公开号：

  WO2015028543A1
• 作为产物：
  描述：

  cystamine dihydrochioride 、 4-氯丁酰氯 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以62%的产率得到N,N'-bis(4-chlorobutyryl)cystamine
  参考文献：
  名称：

  Polymeric redox-responsive delivery systems bearing ammonium salts cross-linked via disulfides

  摘要：

  通过共聚合N,N-二乙基丙烯酰胺（DEAAm）和2-(二甲氨基)乙基甲基丙烯酸甲酯（DMAEMA），合成了一种氧化还原响应性聚阳离子体系。采用N,N'-双(4-氯丁酰基)半胱氨酸作为含二硫键的交联剂，通过季铵化三级胺基团形成网络。不溶性阳离子水凝胶可通过使用二硫苏糖醇（DTT）、三(2-羧乙基)磷酸（TCEP）或半胱氨酸将二硫键还原为巯基而变为可溶性。可溶性聚合体系可以通过在碱性条件下使用氧气或过氧化氢再次交联。氧化还原响应性聚合物网络可用于分子包含和控制释放。例如，苯酚酞、亚甲基蓝和反应性橙16被包含在网络中。经过DTT处理后，染料的释放可以被识别。交联材料的物理性质，如玻璃转变温度（Tg）、膨胀行为和云点（Tc）进行了研究。氧化还原响应性行为通过流变学测量进一步分析。

  DOI：

  10.3762/bjoc.9.189

文献信息

• [EN] PROCESS FOR TREATING KERATIN FIBRES WITH A CATIONIC DISULFIDE COMPOUND<br/>[FR] PROCÉDÉ DE TRAITEMENT DE FIBRES DE KÉRATINE AU MOYEN D'UN COMPOSÉ DE DISULFURE CATIONIQUE
  申请人：OREAL

  公开号：WO2017081122A1

  公开（公告）日：2017-05-18

  Process for treating keratin fibres with a cationic disulfide compound The invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: (i) a step of applying a compound (I) and also the acid or base salts thereof, the optical or geometrical isomers thereof, and the solvates thereof such as hydrates, in which compound of formula (I) R1, R2, R3, R4, x, m, n, X-, areas defined in the description; (ii) a step of heating the keratin fibres to a temperature of at least 100°C, preferably ranging from 100 to 250°C; it is understood that steps (i) and (ii) may be performed at the same time or separately. The process makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect. The invention also relates to the novel compounds and to a cosmetic composition comprising such a compound.

  用阳离子二硫化合物处理角蛋白纤维的方法。本发明涉及一种处理角蛋白纤维的方法，特别是人类角蛋白纤维，如头发，包括：(i) 应用化合物(I)及其酸或碱盐，其光学或几何异构体，以及其溶剂化合物，如水合物的步骤，在该化合物的公式(I)中R1、R2、R3、R4、x、m、n、X-，在描述中有定义；(ii) 将角蛋白纤维加热至至少100°C的温度，最好在100°C至250°C范围内；可以理解的是，步骤(i)和(ii)可以同时或分开进行。该方法可以获得良好的护发化妆品特性，具有持久效果。本发明还涉及新化合物和包含该化合物的化妆品组合物。
• [EN] FLUORESCENT DIRECT DYE BEARING AN ALIPHATIC CHAIN AND A DISULFIDE/THIOL/PROTECTED-THIOL FUNCTION FOR DYEING KERATIN MATERIALS<br/>[FR] COLORANT DIRECT FLUORESCENT PORTANT UNE CHAÎNE ALIPHATIQUE ET UNE FONCTION DE DISULFURE/THIOL/THIOL PROTÉGÉ POUR COLORER DES MATIÈRES KÉRATINIQUES
  申请人：OREAL

  公开号：WO2018206661A1

  公开（公告）日：2018-11-15

  The invention relates to a process for dyeing and/or lightening keratin materials, in particular keratin fibres, preferably human keratin fibres such as the hair, using at least one fluorescent direct dye bearing a disulfide, thiol or protected-thiol function and comprising at least one aliphatic chain of formula (I): A – (X)p – Csat – S – U. The invention also relates to the use i) of at least one fluorescent direct dye bearing a disulfide, thiol or protected-thiol function (I) combined with ii) steam and/or a heating iron for straightening keratin fibres, for dyeing and lightening keratin materials, and to novel fluorescent direct dyes bearing a disulfide, thiol or protected-thiol function of formula (I): A – (X)p – Csat – S – U, and also a cosmetic composition comprising same. The process used and the use of the thiol, protected-thiol or disulfide fluorescent direct dyes of formula (I) combined with steam makes it possible especially to obtain long-lasting colouring with care valency on keratin materials.

  本发明涉及一种用于染色和/或漂白角蛋白质材料，特别是角蛋白质纤维，优选人类角蛋白质纤维（如头发）的过程，使用至少一种带有二硫键，巯基或受保护巯基功能并且包含式（I）中的至少一种脂肪链的荧光直接染料：A -（X）p - Csat-S-U。本发明还涉及i）至少一种带有二硫键，巯基或受保护巯基功能（I）的荧光直接染料与ii）蒸汽和/或加热熨斗结合用于拉直角蛋白质纤维，用于染色和漂白角蛋白质材料，以及具有相同的新型带有二硫键，巯基或受保护巯基功能的荧光直接染料的化妆品组合物。所使用的过程和式（I）的巯基，受保护巯基或二硫键荧光直接染料与蒸汽结合使用，尤其是可以在角蛋白质材料上获得具有护理价值的持久染色。
• STYRYL THIOL/DISULFIDE COMPOUND WITH A HYDROXY(CYCLO)ALKYLAMINO UNIT, PROCESS FOR LIGHTENING KERATIN MATERIALS USING SAME
  申请人：DAUBRESSE Nicolas

  公开号：US20090172897A1

  公开（公告）日：2009-07-09

  The disclosure relates to the dyeing of keratin materials using styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dyes. Disclosed herein is a dye composition comprising a styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dye and a dyeing process with, for example, a lightening effect on keratin materials such as hair, using said composition. Disclosed herein are novel thiol/disulfide fluorescent dyes and the uses thereof in lightening keratin materials. This composition makes it possible to obtain a lightening effect which can be resistant and visible on dark keratin fibers.

  本公开涉及使用苯乙烯基羟基(环)烷基氨基硫醇/二硫化物荧光染料染色角蛋白质材料。本公开揭示了一种染料组合物，包括苯乙烯基羟基(环)烷基氨基硫醇/二硫化物荧光染料和染色工艺，例如，使用该组合物对角蛋白质材料（如头发）进行漂白效果的染色。本公开揭示了新型硫醇/二硫化物荧光染料及其在漂白角蛋白质材料中的用途。该组合物可以获得对深色角蛋白纤维具有耐久性和可见性的漂白效果。
• Azo quinolinium compounds comprising a disulphide/thiol unit, compositions containing same, process for dyeing keratin fibres and device
  申请人：L'Oreal S.A.

  公开号：US07967872B2

  公开（公告）日：2011-06-28

  The present invention relates to thiol/disulphide azo quinolinium compounds for dyeing keratin fibres. The invention relates to a dye composition comprising a particular thiol/disulphide azo quinolinium chromophore-containing thiol or disulphide dye, and to a process for dyeing keratin fibres such as the hair, using said composition. It similarly relates to novel particular thiol/disulphide azo quinolinium chromophore-containing dyes and to the uses thereof in dyeing keratin fibres. The dyeing process according to the invention makes it possible to dye keratin fibres without damaging them, in a manner which is particularly persistent with respect to shampooing operations and common attacks. Moreover, the novel dyes according to the invention extend the colour range to violets and blues. This process also makes it possible to dye bleached keratin fibres in a strong and chromatic manner.

  本发明涉及硫醇/二硫化物偶氮喹啉化合物用于染色角蛋白质纤维。本发明涉及一种染料组合物，包括一种特定的硫醇/二硫化物偶氮喹啉色团含硫醇或二硫化物染料，以及使用该组合物染色角蛋白质纤维（如头发）的过程。它同样涉及新的特定硫醇/二硫化物偶氮喹啉色团染料及其在染色角蛋白质纤维中的用途。本发明的染色过程可以在不损伤纤维的情况下染色，对于洗发和常见攻击非常持久。此外，本发明的新染料扩展了紫色和蓝色的色彩范围。这个过程还可以强烈和色彩鲜艳地染色漂白的角蛋白质纤维。
• AZO QUINOLINIUM COMPOUNDS COMPRISING A DISULPHIDE/THIOL UNIT, COMPOSITIONS CONTAINING SAME, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE
  申请人：Daubresse Nicolas

  公开号：US20100263139A1

  公开（公告）日：2010-10-21

  The present invention relates to thiol/disulphide azo quinolinium compounds for dyeing keratin fibres. The invention relates to a dye composition comprising a particular thiol/disulphide azo quinolinium chromophore-containing thiol or disulphide dye, and to a process for dyeing keratin fibres such as the hair, using said composition. It similarly relates to novel particular thiol/disulphide azo quinolinium chromophore-containing dyes and to the uses thereof in dyeing keratin fibres. The dyeing process according to the invention makes it possible to dye keratin fibres without damaging them, in a manner which is particularly persistent with respect to shampooing operations and common attacks. Moreover, the novel dyes according to the invention extend the colour range to violets and blues. This process also makes it possible to dye bleached keratin fibres in a strong and chromatic manner.

  本发明涉及用于染色角蛋白纤维的巯基/二硫键偶氮喹啉化合物。本发明涉及一种染料组合物，包括特定的巯基/二硫键偶氮喹啉色团含有巯基或二硫键染料，并且涉及一种用于染色角蛋白纤维（如头发）的工艺，使用该组合物。它同样涉及新的特定巯基/二硫键偶氮喹啉色团含有染料及其在染色角蛋白纤维中的用途。本发明的染色工艺使得能够在不损害角蛋白纤维的情况下染色，其染色效果在洗发和常见的攻击方面特别持久。此外，本发明的新染料扩展了紫色和蓝色的色彩范围。此工艺还使得能够强烈和色彩鲜艳地染色漂白的角蛋白纤维。