摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione | 871700-55-9

中文名称
——
中文别名
——
英文名称
1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
英文别名
1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione;1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione
1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione化学式
CAS
871700-55-9
化学式
C23H19FIN3O5
mdl
——
分子量
563.324
InChiKey
JLGZOQPEHPQEGW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    607.4±65.0 °C(Predicted)
  • 密度:
    1.79±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3.3
  • 重原子数:
    33
  • 可旋转键数:
    4
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.17
  • 拓扑面积:
    90.4
  • 氢给体数:
    1
  • 氢受体数:
    6

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量
    • 1
    • 2

反应信息

点击查看最新优质反应信息

文献信息

  • HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
    申请人:LUPIN LIMITED
    公开号:US20150133424A1
    公开(公告)日:2015-05-14
    The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:
    本公开涉及杂环芳基化合物作为MEK抑制剂。这些化合物包括式I的杂环芳基化合物,它们的药用盐,与合适药物的组合以及其制剂。本公开还包括所述化合物的制备方法和它们在治疗方法中的应用。所述化合物的化学式如下:
  • [EN] HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLYLES UTILISÉS COMME INHIBITEURS DE MEK
    申请人:LUPIN LTD
    公开号:WO2016009306A1
    公开(公告)日:2016-01-21
    The present disclosure is related to heterocyclyl compounds as MEK inhibitors. These compounds include heterocyclyl compounds of formula (I) and (Ia), their pharmaceutically acceptable salts, their combinations with suitable medicaments, and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:
    本公开涉及杂环化合物作为MEK抑制剂。这些化合物包括式(I)和(Ia)的杂环化合物,它们的药学上可接受的盐,与适当药物的组合,以及其药物组合物。本公开还包括所述化合物的制备方法和它们在治疗方法中的应用。所述化合物的化学式如下:Formula (I)
  • Pyrimidine compound and medical use thereof
    申请人:Kawasaki Hisashi
    公开号:US20060014768A1
    公开(公告)日:2006-01-19
    The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
    本发明涉及一种嘧啶化合物或其药学上可接受的盐,其由以下式[I]所表示,其中每个符号如规范中所定义,并提供了一种治疗或预防不良细胞增殖的方法,包括给予这种化合物。本发明的化合物在抑制不良细胞增殖,特别是抗肿瘤活性方面具有优越性,并可用作抗肿瘤剂,用于预防或治疗癌症、风湿病等。此外,本发明的化合物在与其他抗肿瘤剂如烷化剂或代谢拮抗剂联合使用时,可成为更有效的抗肿瘤剂。
  • PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
    申请人:Kawasaki Hisashi
    公开号:US20080312228A1
    公开(公告)日:2008-12-18
    The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
    本发明涉及一种嘧啶化合物或其药学上可接受的盐,其由以下公式[I]所表示,其中每个符号如规范中所定义,并提供了一种治疗或预防不良细胞增殖的方法,包括给予这种化合物。本发明的化合物在抑制不良细胞增殖,特别是抗肿瘤活性方面具有优越性,并且可用作抗肿瘤剂,用于预防或治疗癌症、风湿病等。此外,本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时,可成为更有效的抗肿瘤剂。
  • PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
    申请人:Japan Tobacco Inc.
    公开号:US20150183812A1
    公开(公告)日:2015-07-02
    The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
    本发明涉及一种由以下式[I]所表示的嘧啶化合物或其药学上可接受的盐,其中每个符号如规范中所定义,以及治疗或预防不良细胞增殖的方法,包括给予这样的化合物。本发明的化合物在抑制不良细胞增殖,特别是抗肿瘤活性方面具有优越性,并且在预防或治疗癌症、风湿病等方面作为抗肿瘤剂非常有用。此外,本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时,可以更有效地作为抗肿瘤剂。
查看更多

同类化合物

阿昔替酯 螺喹唑啉 苯并[g][1,2,3]三唑并[4',5':5,6]吡啶并[2,1-b]喹唑啉-13(2H)-酮 脱氢利培酮 盐酸曲林菌素 甲硫利马唑 甲基8-乙基-2-甲氧基-5-氧代-5,8-二氢吡啶并[2,3-d]嘧啶-6-羧酸酯 甲基8-乙基-2-(甲硫基)-5-氧代-5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-羧酸酯 甲基2-乙氧基-8-乙基-5-氧代-吡啶并[6,5-d]嘧啶-6-羧酸酯 溴他替尼 泮托拉唑杂质DF 氨甲酸,[(2R,3E)-2-羟基-3-戊烯基]-,1,1-二甲基乙基酯(9CI) 柱孢藻毒素 曲美替尼 曲美替尼 曲喹辛 异噻唑并[5,4-d]嘧啶,3-亚硝基-(9CI) 帕潘立酮棕榈酸酯 帕潘立酮杂质7 帕潘立酮杂质16 帕潘立酮杂质 帕潘立酮杂质 帕潘立酮去氟杂质 帕潘立酮Z-异构体 帕潘立酮 帕泊昔布杂质117 帕布昔利布杂质46 帕博西尼杂质S 帕利哌酮杂质05 帕利哌酮杂质03 帕利哌酮杂质02 帕利哌酮十四酸酯 帕利哌酮N-氧化物 布喹特林 巴马斯汀 奥卡哌酮 多夸司特 嘧啶并[4,5-d]嘧啶-2,4,5(1H,3H,6H)-三酮,7-乙氧基-1,3-二甲基-6-(苯基甲基)- 吡曲克辛 吡嘧司特钾 吡嘧司特 吡啶并[4,3-d]嘧啶-4(1H)-酮,4,5,6,7-四氢-6-甲基-2-苯基- 吡啶并[4,3-D]嘧啶-2,4(1H,3H)-二酮 吡啶并[3,4-D]嘧啶-2,4(1H,3H)-二酮 吡啶并[3,2-d]嘧啶-4(3H)-酮,3-甲基-2-(甲基氨基)- 吡啶并[3,2-d]嘧啶-4(3H)-酮 吡啶并[3,2-d]嘧啶-4(1H)-酮,2,3-二氢-3-(2-羟基苯基)-2-硫代- 吡啶并[3,2-d]嘧啶-2,4(1H,3H)-二酮 吡啶并[2,3-d]嘧啶-7(8h)-酮,2,6-二溴-8-环戊基-5-甲基- 吡啶并[2,3-d]嘧啶-7(8H)-酮