6-bromo-3-chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester | 1121058-30-7

分子结构分类

有机化合物 - 有机杂环化合物 - 咪唑并吡啶类

中文名称

——

中文别名

——

英文名称

6-bromo-3-chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester

英文别名

methyl 6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate

6-bromo-3-chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester化学式

CAS

1121058-30-7

化学式

C₁₀H₅BrClF₃N₂O₂

mdl

——

分子量

357.514

InChiKey

WAXRJBCYCKZBJN-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

密度：

1.87±0.1 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

4.5
重原子数：

19
可旋转键数：

2
环数：

2.0
sp3杂化的碳原子比例：

0.2
拓扑面积：

43.6
氢给体数：

0
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	6-Bromo-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester	1121058-16-9	C₁₀H₆BrF₃N₂O₂	323.069

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1121056-92-5	C₉H₃BrClF₃N₂O₂	343.487
——	methyl 3-chloro-6-ethynyl-8-(trifluoromethyl)imidazo[1,2-a] pyridine-2-carboxylate	1237839-88-1	C₁₂H₆ClF₃N₂O₂	302.64
——	methyl 3-chloro-6-propyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-25-6	C₁₃H₁₂ClF₃N₂O₂	320.699
——	methyl 3-chloro-6-hydroxy-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-35-8	C₁₀H₆ClF₃N₂O₃	294.617
——	methyl 3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1284243-81-7	C₁₃H₁₂ClF₃N₂O₂	320.699
——	methyl 6-butyl-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-31-4	C₁₄H₁₄ClF₃N₂O₂	334.726
——	methyl 3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-29-0	C₁₄H₁₄ClF₃N₂O₂	334.726
——	methyl 3-chloro-8-(trifluoromethyl)-6-[(trimethylsilyl)ethynyl]imidazo[1,2-a]pyridine-2-carboxylate	1237839-87-0	C₁₅H₁₄ClF₃N₂O₂Si	374.822
——	methyl 3-chloro-6-(1-methylethenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1284243-80-6	C₁₃H₁₀ClF₃N₂O₂	318.683
——	methyl 3-chloro-6-(methyloxy)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-37-0	C₁₁H₈ClF₃N₂O₃	308.644
——	methyl 3-chloro-6-(1-methyl-1-propen-1-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-65-4	C₁₄H₁₂ClF₃N₂O₂	332.71
——	3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1284243-83-9	C₁₂H₁₀ClF₃N₂O₂	306.672
——	3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1237839-60-9	C₁₃H₁₂ClF₃N₂O₂	320.699
——	methyl 3-chloro-6-(ethyloxy)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-44-9	C₁₂H₁₀ClF₃N₂O₃	322.671
——	methyl 3-chloro-6-[(1-methylethyl)oxy]-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-55-2	C₁₃H₁₂ClF₃N₂O₃	336.698
——	methyl 3-chloro-6-[(difluoromethyl)oxy]-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-72-3	C₁₁H₆ClF₅N₂O₃	344.625
——	3-chloro-6-[(difluoromethyl)oxy]-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1237839-74-5	C₁₀H₄ClF₅N₂O₃	330.598
——	methyl 3-chloro-6-(3-thienyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1284246-50-9	C₁₄H₈ClF₃N₂O₂S	360.744
——	3-chloro-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-8-trifluoromethylimidazo[1,2-a]pyridine-2-carboxylic acid methyl ester	1237839-57-4	C₁₆H₁₇BClF₃N₂O₄	404.581
——	methyl 3-chloro-6-(2-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-79-0	C₁₄H₈ClF₃N₂O₃	344.677
——	3-chloro-6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1121058-17-0	C₁₃H₆ClF₃N₂O₃	330.65
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-propyl-2-piperazinone	1284245-99-3	C₁₆H₁₅BrClF₃N₄O₂	467.673
——	3-chloro-6-(3-thienyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1284246-52-1	C₁₃H₆ClF₃N₂O₂S	346.717
——	methyl 3-chloro-6-[2-(hydroxymethyl)-2H-1,2,3-triazol-4-yl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate	1237839-91-6	C₁₃H₉ClF₃N₅O₃	375.694
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-butyl-2-piperazinone	1284246-00-9	C₁₇H₁₇BrClF₃N₄O₂	481.7
——	3-chloro-6-(2H-1,2,3-triazol-4-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1237839-92-7	C₁₁H₅ClF₃N₅O₂	331.641
——	3-chloro-6-furan-2-yl-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid	1121056-81-2	C₁₃H₆ClF₃N₂O₃	330.65
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclobutyl-2-piperazinone	1284244-21-8	C₁₇H₁₅BrClF₃N₄O₂	479.684
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1284244-10-5	C₁₈H₁₇BrClF₃N₄O₂	493.711
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(3,3-difluorocycloyl)-2-piperazinone	1284244-36-5	C₁₇H₁₃BrClF₅N₄O₂	515.665
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(4-oxocyclohexyl)-2-piperazinone	1284244-33-2	C₁₉H₁₇BrClF₃N₄O₃	521.721
——	3-Chloro-6-cyclopropyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carbonyl chloride	1284246-41-8	C₁₂H₇Cl₂F₃N₂O	323.102
——	3-chloro-6-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1H-pyrrol-3-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid	1237839-83-6	C₁₈H₁₅ClF₃N₃O₄	429.783
——	4-{[6-bromo-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(4,4-difluorocyclohexyl)-2-piperazinone	1284244-27-4	C₁₉H₁₇BrClF₅N₄O₂	543.719
——	4-{[3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclobutyl-2-piperazinone	1284245-74-4	C₂₁H₂₄ClF₃N₄O₂	456.895
——	4-{[3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1284245-72-2	C₂₂H₂₆ClF₃N₄O₂	470.922
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1284246-68-9	C₂₁H₂₄ClF₃N₄O₂	456.895
——	4-{[3-chloro-6-propyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclohexyl-2-piperazinone	1284245-44-8	C₂₂H₂₆ClF₃N₄O₂	470.922
——	4-{[3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclohexyl-2-piperazinone	1284245-45-9	C₂₃H₂₈ClF₃N₄O₂	484.949
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclohexyl-2-piperazinone	1284246-66-7	C₂₂H₂₆ClF₃N₄O₂	470.922
——	4-{[6-butyl-3-chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclohexyl-2-piperazinone	1284245-47-1	C₂₃H₂₈ClF₃N₄O₂	484.949
——	4-{[3-chloro-6-(methyloxy)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclobutyl-2-piperazinone	1284245-75-5	C₁₈H₁₈ClF₃N₄O₃	430.814
——	4-{[3-chloro-6-[(difluoromethyl)oxy]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclobutyl-2-piperazinone	1284246-47-4	C₁₈H₁₆ClF₅N₄O₃	466.795
——	(+/-)-4-{[3-chloro-6-(tetrahydro-2-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1284245-52-8	C₂₂H₂₄ClF₃N₄O₃	484.906
——	(+/-)-4-{[3-chloro-6-cyclopropyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-6-methyl-2-piperazinone	1284246-33-8	C₂₂H₂₄ClF₃N₄O₂	468.906
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(3-thienyl)-2-piperazinone	1284243-79-3	C₂₀H₁₈ClF₃N₄O₂S	470.903
——	4-{[3-chloro-6-[(1-methylethyl)oxy]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1284245-59-5	C₂₁H₂₄ClF₃N₄O₃	472.895
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(1,3-thiazol-4-yl)-2-piperazinone	1284243-92-0	C₁₉H₁₇ClF₃N₅O₂S	471.89
——	(+/-)-4-{[3-chloro-6-(tetrahydro-3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-cyclopentyl-2-piperazinone	1329623-59-7	C₂₂H₂₄ClF₃N₄O₃	484.906
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(3-fluorophenyl)-2-piperazinone	1284246-69-0	C₂₂H₁₉ClF₄N₄O₂	482.865
——	4-{[3-chloro-6-(1-methylethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(1,3-thiazol-2-yl)-2-piperazinone	1284246-64-5	C₁₉H₁₇ClF₃N₅O₂S	471.89
——	4-{[3-chloro-6-(2-methylpropyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-1-(1,3-thiazol-2-yl)-2-piperazinone	1284245-69-7	C₂₀H₁₉ClF₃N₅O₂S	485.917