4-methyl-3-phenyl-2-p-toluenesulfonyl-1H-pyrrole | 374572-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-methyl-3-phenyl-2-p-toluenesulfonyl-1H-pyrrole
• 英文别名: 4-methyl-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-pyrrole；4-methyl-2-(4-methylphenyl)sulfonyl-3-phenyl-1H-pyrrole
• CAS: 374572-47-1
• 化学式: C₁₈H₁₇NO₂S
• 分子量: 311.404
• InChiKey: CVDXPWADTRTBIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-3-phenyl-2-p-toluenesulfonyl-1H-pyrrole 在 (氯亚甲基)二甲基氯化铵 、 水 、 碳酸氢钠 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 16.0h， 以46%的产率得到3-methyl-5-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrrole-2-carbaldehyde
  参考文献：
  名称：

  ACID SECRETION INHIBITOR

  摘要：

  公开号：

  EP2005957B1
• 作为产物：
  描述：

  对甲基苯磺酰甲基异腈 、 1-苯基-2-硝基-1-丙醇乙酸酯 在 四甲基胍 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 以53%的产率得到4-methyl-3-phenyl-2-p-toluenesulfonyl-1H-pyrrole
  参考文献：
  名称：

  胆红素的芳香同源物：合成，立体化学，葡萄糖醛酸化和肝转运

  摘要：

  通过将两个新的对称胆红素苯基胆红素类似物（2和3）的混合物进行结构加扰反应，制备了一个新的苯酚色素胆红素-IXα（胆红素，图1）的合成类似物（1），其中苯基取代了乙烯基。 -XIIIα和IIIα。前者（2）具有两个内切-phenyls，而后者（3）具有两个外-phenyls通过一个dipyrrylmethane二醛与适当methylphenylpyrrolinones，将其在几个步骤中制备的由4-甲基-3-苯基-2的缩合合成-（对甲苯磺酰基）吡咯，由Barton-Zard吡咯合成而得。核过载效应11 – 3的1 H NMR研究证实，与它们的胆红素当量一样，这些橙黄色颜料采用分子内氢键键合的脊-瓦构象。反相HPLC和TLC表明3的极性小于2，而1的极性中等。在的感应圆二色光谱差异大1 - 3中的人血清白蛋白的pH7.4的缓冲水溶液中发现。

  DOI：

  10.1016/s0040-4020(01)00773-6

文献信息

• Acid Secretion Inhibitor
  申请人：Hasuoka Atsushi

  公开号：US20090118335A1

  公开（公告）日：2009-05-07

  The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X 1 and X 2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X 3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R 1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R 2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R 3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X 1 , X 2 and X 3 , and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

  本发明提供了一种具有优异的抑制酸分泌、抗溃疡活性等的化合物。该质子泵抑制剂包含由式(I)表示的化合物，其中环A是饱和或不饱和的5-或6-成员环基团，可选地具有作为环构成原子的碳原子以外的1至4个异原子，所述异原子选自氮原子、氧原子和硫原子，环构成原子X1和X2分别为碳原子或氮原子，环构成原子X3为碳原子、氮原子、氧原子或硫原子，R1为可选取代的芳基基团或可选取代的杂环基团，R2为可选取代的烷基基团、可选取代的芳基基团或可选取代的杂环基团，R3为氨甲基基团，可选地被1或2个低碳基取代，该基团是除X1、X2和X3以外的环构成原子上的取代基，环A可选地进一步具有从低碳基、卤素原子、氰基和氧代基中选择的取代基，或其盐或前药。
• ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS
  申请人：Hasuoka Atsushi

  公开号：US20110288040A1

  公开（公告）日：2011-11-24

  The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X 1 and X 2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X 3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R 1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R 2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R 3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X 1 , X 2 and X 3 , and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

  本发明提供了一种具有优异的抑制酸分泌作用、抗溃疡活性等的化合物。一种质子泵抑制剂，包含一种由式(I)表示的化合物，其中环A是一个饱和或不饱和的5或6元环基团，可选地具有除碳原子外的1到4个异原子，所述异原子选自氮原子、氧原子和硫原子，环构成原子X1和X2分别是碳原子或氮原子，环构成原子X3是碳原子、氮原子、氧原子或硫原子，R1是可选取代的芳基基团或可选取代的杂环芳基基团，R2是可选取代的烷基基团、可选取代的芳基基团或可选取代的杂环芳基基团，R3是在除X1、X2和X3之外的环构成原子上取代的氨甲基基团，可选地被1或2个较低烷基取代，环A可选地进一步具有来自较低烷基、卤素原子、氰基和氧基的取代基，或其盐或前药。
• Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US07994205B2

  公开（公告）日：2011-08-09

  The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. The compound has superior acid secretion inhibitory action, an antiulcer activity and the like.

  本发明提供了一种芳基或杂环芳基化合物，其化学式为(Ia)或(Ib)，其中每个符号如规范中所定义，或其盐，或包括该化合物和药用可接受载体的药物组合物。该化合物具有优异的酸分泌抑制作用，抗溃疡活性等。
• Aryl- or heteroaryl-sulfonyl compounds as acid secretion inhibitors
  申请人：Hasuoka Atsushi

  公开号：US08686010B2

  公开（公告）日：2014-04-01

  The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.

  本发明提供了一种具有优良的酸分泌抑制作用、抗溃疡活性等的化合物。一种质子泵抑制剂包含式（I）所表示的化合物，其中环A是一个饱和或不饱和的5-或6-成员环基团，选项包括作为环构成原子的碳原子以外的1到4个异原子，所述异原子选自氮原子、氧原子和硫原子，环构成原子X1和X2分别是碳原子或氮原子，环构成原子X3是碳原子、氮原子、氧原子或硫原子，R1是可选的取代芳基基团或可选的取代杂环芳基基团，R2是可选的取代烷基基团、可选的取代芳基基团或可选的取代杂环芳基基团，R3是氨甲基基团，该基团可选地由1或2个低碳烷基取代，该基团是除X1、X2和X3外的环构成原子上的取代基，并且环A还可以进一步具有从低碳烷基、卤素原子、氰基和氧代基中选择的取代基，或其盐或前药。
• US7994205B2
  申请人：——

  公开号：US7994205B2

  公开（公告）日：2011-08-09