1-[4-(4-哌啶基氧基)苯基]乙酮 | 97840-07-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[4-(4-哌啶基氧基)苯基]乙酮
• 英文名称: 4-(4-acetylphenoxy)piperidine
• 英文别名: 1-{4-[(Piperidin-4-yl)oxy]phenyl}ethan-1-one；1-(4-piperidin-4-yloxyphenyl)ethanone
• CAS: 97840-07-8
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: VIQQHIFMUUEXLB-UHFFFAOYSA-N

物化性质

• 沸点：
  371.3±32.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[4-(4-哌啶基氧基)苯基]乙酮 生成 2-[4-(4-acetylphenoxy)piperidin-1-yl]-1-naphthalen-2-ylethanone;hydrochloride
  参考文献：
  名称：

  SUGIMOTO, XATIRO;NAKAMURA, TAKAXARU;KARIBEH, NORIO;UEHNO, KOTSUGI;SAJTO, +

  摘要：

  DOI：

文献信息

• Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04518713A1

  公开（公告）日：1985-05-21

  There are described analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines of the formula ##STR1## where X is hydrogen, loweralkyl, CF.sub.3, acetyl or halogen; n is 1 or 2; R.sub.1 is H.sub.2 or oxygen; R.sub.2 is H, loweralkyl or benzyl; and R.sub.3 is oxygen or --OCH.sub.2 CH.sub.2 O--, which are useful as analgesic agents and intermediate compounds therefor.

  描述了一种镇痛替代的1-氨基烷基氨基-4-芳氧基哌啶类化合物，其化学式为##STR1##其中X为氢、较低烷基、CF.sub.3、乙酰基或卤素；n为1或2；R.sub.1为H.sub.2或氧；R.sub.2为H、较低烷基或苄基；R.sub.3为氧或--OCH.sub.2 CH.sub.2 O--，这些化合物可用作镇痛剂和其中间体化合物。
• [EN] QUINOXALINE DERIVATIVES AS GPR6 MODULATORS<br/>[FR] DÉRIVÉS DE QUINOXALINE EN TANT QUE MODULATEURS DU GPR6
  申请人：ENVOY THERAPEUTICS INC

  公开号：WO2014028479A1

  公开（公告）日：2014-02-20

  The present invention provides compounds of Formula (I) that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明提供了式(I)化合物，该化合物是GPR6调节剂，因此可用于治疗可通过调节GPR6来治疗的疾病，特别是治疗帕金森病、左旋多巴诱导的舞蹈病、亨廷顿病、其他舞蹈病、运动不能、涉及纹状体功能障碍的运动障碍、精神分裂症和药物成瘾。还提供了含有此类化合物的药物组合物以及制备此类化合物的过程。
• QUINOXALINE DERIVATIVES AS GPR6 MODULATORS
  申请人：ENVOY THERAPEUTICS, INC.

  公开号：US20150232469A1

  公开（公告）日：2015-08-20

  The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明提供的化合物为式(I)的GPR6调节剂，因此可用于治疗可通过GPR6调节治疗的疾病，特别是治疗帕金森病、左多巴引起的运动障碍、亨廷顿病、其他运动障碍、无动力障碍以及涉及纹状体功能障碍的运动障碍、精神分裂症和药物成瘾。还提供了含有这种化合物的制药组合物以及制备这种化合物的过程。
• Substituted 1-aminoalkylamino-4-aryloxypiperidines, a process for their preparation, intermediates thereof, and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0158283A2

  公开（公告）日：1985-10-16

  The present invention relates to substituted-1-amino- alkylamino-4-aryloxypiperidines of the formula where X is hydrogen, loweralkyl, CF3, acetyl or halogen; n is 1 or 2; R, is H2 or oxygen; R2 is H, loweralkyl or benzyl; and R3 is oxygen or -O-CH2CH2-O-, which are useful as analgesic agents, a process for their preparation and intermediate compounds therefor.

  本发明涉及式中 X 为氢、低级烷基、CF3、乙酰基或卤素；n 为 1 或 2；R，为 H2 或氧；R2 为 H、低级烷基或苄基；R3 为氧或 -O-CH2CH2-O-的取代-1-氨基-烷基氨基-4-芳氧基哌啶，它们可用作镇痛剂，本发明还涉及其制备方法和中间化合物。
• HETEROCONDENSED PYRIDONES COMPOUNDS AND THEIR USE AS IDH INHIBITORS
  申请人：Nerviano Medical Sciences S.r.l.

  公开号：EP3797107A1

  公开（公告）日：2021-03-31