Z-Gly-DL-Phe | 5540-03-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Gly-DL-Phe
• 英文别名: N-[(benzyloxy)carbonyl]glycylphenylalanine；3-phenyl-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanoic acid
• CAS: 5540-03-4
• 化学式: C₁₉H₂₀N₂O₅
• mdl: MFCD00063161
• 分子量: 356.378
• InChiKey: FLGYJBNDDWLTQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Z-Gly-DL-Phe 在 硝基甲烷 、 氢溴酸 作用下， 生成 glycylphenylalanine
  参考文献：
  名称：

  Acid-catalyzed Decarbobenzoxylation

  摘要：

  DOI：

  10.1021/ja01117a053
• 作为产物：
  描述：

  L-苯丙氨酸甲酯盐酸盐 在 thermolysin sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成 Z-Gly-DL-Phe
  参考文献：
  名称：

  EP1974732

  摘要：

  公开号：

文献信息

• α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles
  作者：Uroš Grošelj、Mojca Žorž、Amalija Golobič、Branko Stanovnik、Jurij Svete

  DOI：10.1016/j.tet.2013.11.008

  日期：2013.12

  simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose

  的新颖的新的和简单的合成ñ -保护的5-取代-4-羟基吡咯-3-羧酸酯，其存在于与他们的4-氧代互变异构体平衡，已经在从开始的两个步骤被开发ñ -保护的α氨基酸。关键中间体是烯胺酮，其也被分离，表征，并用于其它官能化杂环的结构，才自发分解到吡咯产物。4-羟基吡咯易于部分空中氧化，但是可以有效地烷基化或还原成稳定的多取代的吡咯烷衍生物。
• Polymer-Supported Mukaiyama Reagent:  A Useful Coupling Reagent for the Synthesis of Esters and Amides
  作者：Stefano Crosignani、Jerome Gonzalez、Dominique Swinnen

  DOI：10.1021/ol0480372

  日期：2004.11.1

  Polymer-supported N-alkyl-2-chloro pyridinium triflate was synthesized in one step from Wang resin. This reagent proved to be a very effective coupling reagent for the synthesis of esters or amides from carboxylic acids and alcohols or amines (primary and secondary). [reaction: see text]

  由Wang树脂一步合成了聚合物负载的N-烷基-2-氯吡啶鎓三氟甲磺酸盐。该试剂被证明是从羧酸和醇或胺（伯和仲）合成​​酯或酰胺的非常有效的偶联剂。[反应：看文字]
• The history of Iberian archaeology: one archaeology for two Spains
  作者：Arturo Ruiz、Alberto Sánchez、Juan P. Bellón

  DOI：10.1017/s0003598x00089973

  日期：2002.3

  Introduction

  In this article we set out to analyse, from an archaeological point of view, a political problem which, as demonstrated by current debate, including acts of violence, goes well beyond archaeology. Throughout the 19th century, and especially in its latter half, a centralist political model for Spain was developed in which a political balance could not be found between the State and [lie autonomous traditions of the varions regions of the Iherian Peninsula. As a result of this failure, legitimation programmes began to be constructed towards the end of 19th century, based on the history of the peoples of these regions. This led to a search in protohistorical archaeology [Iberians, Celts, Tartessians, etc.) for a possible solution to the political problems caused by a lack of institutional agreement between states and regions.

  引言 本文旨在从考古学的角度分析一个政治问题，正如当前的辩论（包括暴力行为）所表明 的那样，这个问题远远超出了考古学的范畴。在整个 19 世纪，尤其是后半叶，西班牙形成了一种中央集权的政治模式，在这种模式下，国家与伊赫里亚半岛各地区的自治传统之间无法达成政治平衡。由于这一失败，西班牙在 19 世纪末开始根据这些地区人民的历史制定合法化方案。这促使人们在原历史考古学（伊比利亚人、凯尔特人、鞑靼人等）中寻找可能的办法，以解决国家和地区之间缺乏制度性协议所造成的政治问题。
• A useful synthesis of peptides
  作者：R.B. Woodward、R.A. Olofson、H. Mayer

  DOI：10.1016/s0040-4020(01)82192-x

  日期：1966.1

  Carboxylates react rapidly and smoothly with 3-unsubstituted isoxazolium salts under very mild conditions to yield enol esters. In this paper we report the application of this reaction as the carboxyl-activating step in a simple and practical synthesis of peptides. The utility of the specific peptide forming reagent, N-ethyl-5-phenylisoxazolium-3′-sulfonate, is described in some detail.

  羧酸盐在非常温和的条件下与3-未取代的异恶唑鎓盐快速平稳地反应，生成烯醇酯。在本文中，我们报告了该反应作为简单而实用的肽合成中的羧基活化步骤的应用。详细描述了特定的肽形成试剂N-乙基-5-苯基异恶唑-3'-磺酸盐的用途。
• A Divergent Strategy for Site‐Selective Radical Disulfuration of Carboxylic Acids with Trisulfide‐1,1‐Dioxides
  作者：Zijun Wu、Derek A. Pratt

  DOI：10.1002/anie.202104595

  日期：2021.7.5

  direct conversion of carboxylic acids into disulfides is described. The approach employs oxidative photocatalysis for base-promoted decarboxylation of the substrate, which yields an alkyl radical that reacts with a trisulfide dioxide through homolytic substitution. The trisulfide dioxides are easily prepared by a newly described approach. 1°, 2°, and 3° carboxylic acids with varied substitution are good

  描述了羧酸直接转化为二硫化物。该方法采用氧化光催化对底物进行碱促进脱羧，产生烷基自由基，通过均裂取代与二氧化三硫化物反应。二氧化三硫化物很容易通过新描述的方法制备。具有不同取代度的 1°、2° 和 3° 羧酸是良好的底物，包括氨基酸和具有高度活化的 CH 键的底物。二氧化三硫化物也用于通过自由基中继序列实现酰胺的 γ-C(sp 3 )-H 二硫化。在这两个反应中，由取代产生的磺酰基会促进反应。已经探索了控制三硫化物二氧化物在 S2 与 S3 处的取代选择性的因素。