4-二乙氨基哌啶 | 143300-64-5

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-二乙氨基哌啶
• 中文别名: 4-二乙胺基哌啶；4-二乙基氨基哌啶
• 英文名称: 4-diethylaminopiperidine
• 英文别名: N,N-diethylpiperidin-4-amine；4-Diethylamino-piperidine
• CAS: 143300-64-5
• 化学式: C₉H₂₀N₂
• mdl: MFCD04971982
• 分子量: 156.271
• InChiKey: OUXRMEUJNPVXMM-UHFFFAOYSA-N

物化性质

• 沸点：
  108°C/6mm
• 密度：
  0.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933399090
• 危险性防范说明：
  P280
• 危险性描述：
  H302+H312+H332
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Diethylamino-piperidine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Diethylamino-piperidine
CAS number: 143300-64-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H20N2
Molecular weight: 156.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-二乙氨基哌啶 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成 (+/-)-8-cyclohexyl-1a-[[4-(diethylamino)-1-piperidinyl]carbonyl]-N-[(dimethylamino)sulfonyl]-1,1a,2,12b-tetrahydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide
  参考文献：
  名称：

  Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors

  摘要：

  该发明涵盖了Formula I的化合物，其药用盐，组合物以及使用这些化合物的方法。这些化合物对丙型肝炎病毒（HCV）具有活性，并可用于治疗感染HCV的患者。

  公开号：

  US20070060565A1
• 作为产物：
  描述：

  Benzyl 4-(diethylamino)piperidine-1-carboxylate 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 反应 16.0h， 生成 4-二乙氨基哌啶
  参考文献：
  名称：

  CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

  摘要：

  一种化合物对疼痛，特别是神经病性疼痛和/或纤维肌痛综合征具有强烈的镇痛作用。该环胺衍生物由以下公式代表，其前药或药理学上可接受的盐： 其中A代表由公式（IIa）、（IIb）或（IIc）表示的基团： 其中 R 3 代表氢原子或具有1至6个碳原子的烷基基团，R 4 代表氢原子或具有2至6个碳原子的烷基羰基基团或具有1至6个碳原子的烷基基团，并且可选择地被取代为具有2至6个碳原子的烷基羰基氨基基团，n代表1或2，在其中当R 3 和R 4 各自独立地代表具有1至6个碳原子的烷基基团时，R 1 代表具有1至6个碳原子的烷基基团，并且被取代为具有羟基、氨基或羧基。

  公开号：

  US20160194302A1

文献信息

• MODIFIED COMPOUND OF ANDROGRAPHOLIDE
  申请人：Heilongjiang Zhenbaodao Pharmaceutical Co., Ltd.

  公开号：US20180346438A1

  公开（公告）日：2018-12-06

  The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.

  本公开披露了穿心莲内酯的修改化合物，特别是公开了公式(I)和(II)所示的化合物或其药用可接受的盐。
• Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite
  作者：Jia Hao Pang、Atsushi Kaga、Shunsuke Chiba

  DOI：10.1039/c8cc05979a

  日期：——

  A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

  在碘化锂（LiI）存在下，使用氢化钠（NaH）开发了甲氧基吡啶及其衍生物亲核胺化的新方案。该方法提供了对可能具有医学意义的各种氨基吡啶的简洁途径。
• Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.
  作者：Seigo SAWADA、Satoru OKAJIMA、Ritsuo AIYAMA、Ken-ichiro NOKATA、Tomio FURUTA、Teruo YOKOKURA、Eiichi SUGINO、Kentaro YAMAGUCHI、Tadashi MIYASAKA

  DOI：10.1248/cpb.39.1446

  日期：——

  Nevel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HC1 salts wiht the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors.The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.

  Nevel 36衍生物（6个）通过单氨基甲酸酯连接，将7-乙基-10-羟基喜树碱（4）的酚羟基与二胺结合，经过合成并在体内评估了它们的抗肿瘤活性。这些衍生物作为盐酸盐在水中有较好的溶解度，且其E内酯环保持完整，并表现出显著的抗肿瘤活性。其中一种衍生物6-27对L1210白血病和其他小鼠肿瘤显示出极佳的活性。其三水合盐酸盐（CPT-11）的结构通过光谱学和结晶学方法得以确定。
• Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation
  作者：Li-Jun Wang、Chuan-Long Guo、Xiang-Qian Li、Shuai-Yu Wang、Bo Jiang、Yue Zhao、Jiao Luo、Kuo Xu、Hua Liu、Shu-Ju Guo、Ning Wu、Da-Yong Shi

  DOI：10.3390/md15110343

  日期：——

  A series of bromophenol hybrids with N-containing heterocyclic moieties were designed, and their anticancer activities against a panel of five human cancer cell lines (A549, Bel7402, HepG2, HCT116 and Caco2) using MTT assay in vitro were explored. Among them, thirteen compounds (17a, 17b, 18a, 19a, 19b, 20a, 20b, 21a, 21b, 22a, 22b, 23a, and 23b) exhibited significant inhibitory activity against the

  设计了一系列具有含氮杂环部分的溴酚杂化物，并在体外使用MTT法检测了它们对五种人类癌细胞系（A549，Bel7402，HepG2，HCT116和Caco2）的抗癌活性。其中，十三种化合物（17a，17b，18a，19a，19b，20a，20b，21a，21b，22a，22b，23a和23b）对测试的癌细胞系表现出显着的抑制活性。讨论了溴酚衍生物的构效关系（SAR）。有希望的候选化合物17a可以通过机制研究诱导细胞周期停滞在G0 / G1期并诱导A549细胞凋亡，以及引起DNA片段化，形态变化和ROS生成。此外，观察到化合物17a抑制了A549细胞中Bcl-2的水平（抗凋亡蛋白Bcl-2的表达降低和Bcl-2的表达水平下调）以及激活caspase-3和PARP，这表明化合物17a通过ROS介导的凋亡途径在体外诱导A549细胞凋亡。这些结果可能对溴酚衍生物作为新型抗癌药的探索和开发有用。
• [EN] SUBSTITUTED UREA DERIVATIVES AND USES THEREOF IN MEDICINE<br/>[FR] DÉRIVÉS D'URÉE SUBSTITUÉS ET LEUR UTILISATION EN MÉDECINE
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2015043492A1

  公开（公告）日：2015-04-02

  Provided herein are substituted urea derivatives or stereoisomers, geometric isomers, tautomers, N-oxides, hydrates, solvates, metabolites, esters, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions thereof, which are useful in modulating the FLT3 kinase activity, inhibiting FLT3-ITD, and treating the diseases mediated by FLT3 kinase or caused by FLT3-ITD.

  本文提供了替代尿素衍生物或其立体异构体、几何异构体、互变异构体、N-氧化物、水合物、溶剂合物、代谢物、酯类、药学上可接受的盐或其前药，以及用于调节FLT3激酶活性、抑制FLT3-ITD并治疗由FLT3激酶介导或由FLT3-ITD引起的疾病的药物组合物。