1-[3-[4-[2-((E)-2-phenylethenyl)-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole | 202592-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[3-[4-[2-((E)-2-phenylethenyl)-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole
• 英文别名: 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole；2-[(E)-2-phenylethenyl]-4-[[4-[3-(1,2,4-triazol-1-yl)propyl]phenoxy]methyl]-1,3-oxazole
• CAS: 202592-52-7
• 化学式: C₂₃H₂₂N₄O₂
• 分子量: 386.453
• InChiKey: JTTLJDZKGGLCQT-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1H-1,2,4-三唑 、 1-[3-[4-[2-((E)-2-phenylethenyl)-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole 、 6-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]hexanol 以65%的产率得到1-[6-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]hexyl]-1,2,4-triazole
  参考文献：
  名称：

  Heterocyclic compounds, their production and use

  摘要：

  通式（I）代表的杂环化合物，其中R代表一个可选择取代的芳香杂环基团；X代表氧原子，一个可选择氧化的硫原子，—C(═O)—或—CH(OH)—；Y代表CH或N；m表示0到10的整数；n表示1到5的整数；环状基团代表一个可选择取代的芳香唑基团；环A可以是可选择进一步取代的，或其盐。化合物（I）具有抑制酪氨酸激酶的作用，并可用作抗肿瘤剂。

  公开号：

  US06211215B1
• 作为产物：
  描述：

  1H-1,2,4-三唑 、 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl] propanol 、 偶氮二甲酸二乙酯 在 三丁基膦 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到1-[3-[4-[2-((E)-2-phenylethenyl)-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole
  参考文献：
  名称：

  EP1136079

  摘要：

  公开号：

文献信息

• SUSTAINED RELEASE COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1291023A1

  公开（公告）日：2003-03-12

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  通过含有或混合生理活性非肽物质和具有两个或两个以上羧基末端的可生物降解聚合物或其盐制备的组合物具有以下特点：（1）可以含有更多生理活性非肽物质，并且可以控制或加速其释放，从而实现安全的药效；（2）当生理活性非肽物质引起皮下刺激时，预计具有在其末端具有强酸性基团的活性来取消刺激；以及（3）高玻璃转变温度和高稳定性。
• MEDICINAL SOLUTIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1374855A1

  公开（公告）日：2004-01-02

  The present invention relates to a pharmaceutical solution containing a physiologically active non-peptide substance, an organic acid and a biocompatible organic solvent, and provides a pharmaceutical solution wherein a physiologically active non-peptide substance is dissolved at a high concentration.

  本发明涉及一种含有生理活性非肽物质、有机酸和生物相容性有机溶剂的药物溶液，并提供了一种药物溶液，其中生理活性非肽物质以高浓度溶解。
• [EN] THIENOPYRIMIDINE COMPOUNDS, THEIR PRODUCTION AND USE<br/>[FR] COMPOSES DE THIENOPYRIMIDINE, LEUR PRODUCTION ET LEUR UTILISATION
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2000056739A1

  公开（公告）日：2000-09-28

  A compound of formula (I) wherein R?1 and R2¿ each is hydrogen, hydroxy, C¿1-4? alkoxy, C1-4 alkoxy-carbonyl or C1-4 alkyl which may be substituted; R?3¿ is hydrogen, halogen, hydroxy or C¿1-4? alkoxy which may be substituted; or adjacent two R?3¿ may form C¿1-4? alkylenedioxy; R?4¿ is hydrogen or C¿1-4? alkyl; R?6¿ is C¿1-4? alkyl which may be substituted or a group of the formula (A) wherein R?5¿ is hydrogen or R?4 and R5¿ may form heterocycle; and n is 0-5, or a salt thereof, has an excellent GnRH-antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases.

  化合物的化学式（I）其中R1和R2分别是氢，羟基，C1-4烷氧基，C1-4烷氧羰基或C1-4烷基，可能被取代; R3是氢，卤素，羟基或C1-4烷氧基，可能被取代; 或相邻的两个R3可以形成C1-4烷基二氧桥; R4是氢或C1-4烷基; R6是C1-4烷基，可能被取代或具有(A)式中R5为氢或R4和R5可以形成杂环的基团; n为0-5，或其盐，具有优异的GnRH拮抗活性，并且可用于预防或治疗性激素依赖性疾病。
• THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20140221381A1

  公开（公告）日：2014-08-07

  The present invention provides a compound represented by the formula: wherein R 1 is a C 1-4 alkyl; R 2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C 1-4 alkyl and (4′) a C 1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C 1-4 alkoxy-C 1-4 alkyl, (3′) a mono-C 1-4 alkyl-carbamoyl-C 1-4 alkyl, (4′) a C 1-4 alkoxy and (5′) a mono-C 1-4 alkylcarbamoyl-C 1-4 alkoxy, or the like; R 3 is a C 1-4 alkyl; R 4 is a C 1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.

  本发明提供了一种化合物，其表示为式：其中，R1是C1-4烷基；R2是(1)含氮的5-7元杂环基团，该基团可以具有从群组(1')卤素，(2')羟基，(3')C1-4烷基和(4')C1-4烷氧基中选择的取代基，或(2)苯基，该苯基可以具有从群组(1')卤素，(2')C1-4烷氧基-C1-4烷基，(3')单个C1-4烷基-氨基甲酰-C1-4烷基，(4')C1-4烷氧基和(5')单个C1-4烷基-氨基甲酰-C1-4烷氧基等中选择的取代基；R3是C1-4烷基；R4是C1-4烷氧基或类似物；n是1到4的整数；或其盐，作为一种具有促性腺激素释放激素拮抗活性的噻唑嘧啶化合物。
• Agent that retards transformation of hormone-dependent cancer to non-hormone-dependent cancer
  申请人：Matsutani Etsuya

  公开号：US20060135435A1

  公开（公告）日：2006-06-22

  The present invention relates to a composition that retards the transformation of a hormone-dependent cancer to a non-hormone-dependent cancer, which contains a hormonal agent. The composition of the present invention that retards the transformation of a hormone-dependent cancer to a non-hormone-dependent cancer, which contains a hormonal agent, is capable of efficiently exhibiting a retarding effect on the transformation of a hormone-dependent cancer to a non-hormone-dependent cancer.

  本发明涉及一种含有激素剂的组合物，用于延缓激素依赖性癌症向非激素依赖性癌症的转化。本发明的含有激素剂的组合物能够有效地对激素依赖性癌症向非激素依赖性癌症的转化产生延缓作用。