(2-pyridyl)methyl tri-n-butylphosphonium chloride | 691868-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2-pyridyl)methyl tri-n-butylphosphonium chloride
• 英文别名: (2-Pyridyl)methyltri-n-butylphosphonium chloride；tributyl(pyridin-2-ylmethyl)phosphanium;chloride
• CAS: 691868-24-3
• 化学式: C₁₈H₃₃NP*Cl
• 分子量: 329.893
• InChiKey: SORFFONWCPCVFW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯甲基吡啶 、 三丁基膦 以 苯 为溶剂， 反应 18.0h， 生成 (2-pyridyl)methyl tri-n-butylphosphonium chloride
  参考文献：
  名称：

  EPOTHILONE ANALOGUES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR USE AND THEIR PREPA RATIONS

  摘要：

  本发明涉及新型的15-成员噻唑内酯或内酰胺多酮化合物，它们的药物组合物，它们的用途和它们的制备。所公开的化合物涉及一般式I的化合物，它们的制备以及它们用于制备作为细胞抑制剂使用的治疗组合物。

  公开号：

  US20110112149A1

文献信息

• Trans-9,10-dehydroepothilone C and D, analogs thereof and methods of making the same
  申请人：——

  公开号：US20040152708A1

  公开（公告）日：2004-08-05

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了基于trans-9,10-dehydroepothilone C和trans-9,10-dehydroepothilone D的新衍生物化合物、组合物和方法，用于体外抑制细胞过度增殖和/或稳定微管，并用于体内治疗过度增殖性疾病。本发明还揭示了制备这些化合物的方法。
• TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME
  申请人：Li Yong

  公开号：US20090186927A1

  公开（公告）日：2009-07-23

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了基于新的trans-9,10-dehydroepothilone C和trans-9,10-dehydroepothilone D衍生物化合物、组合物和方法，在体外抑制细胞过度增殖和/或稳定微管，并在体内治疗过度增殖性疾病。还揭示了制备这些化合物的方法。
• Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same
  申请人：Kosan Biosciences Incorporated

  公开号：EP2135867A1

  公开（公告）日：2009-12-23

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了新的反式-9,10-脱氢埃坡霉素 C 和反式-9,10-脱氢埃坡霉素 D 衍生物化合物、组合物以及体外抑制细胞过度增殖和/或稳定微管和体内治疗过度增殖性疾病的方法。还公开了制造这些化合物的方法。
• TRANS-9, 10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME
  申请人：Kosan Biosciences Incorporated

  公开号：EP2135868A1

  公开（公告）日：2009-12-23

  The present invention provides a method of making trans-9,10-dehydroepothilones, comprising converting a 9-oxo-epothilone into the trans-9,10-dehydroepothilone.

  本发明提供了一种制造反式-9,10-脱氢埃坡霉素酮的方法，包括将 9-氧代埃坡霉素酮转化为反式-9,10-脱氢埃坡霉素酮。
• EPOTHILONE ANALOGUES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR USE AND THEIR PREPARATIONS
  申请人：Tang, Li

  公开号：EP2261221A1

  公开（公告）日：2010-12-15

  The present invention discloses novel Epothilone analogues, their pharmaceutical compositions, their use and their preparations, especially discloses the compounds of general formula I, their preparations and their use for preparing therapeutical compositions used as cell inhibitors.

  本发明公开了新型埃博霉素类似物、它们的药物组合物、它们的用途和它们的制剂，特别是公开了通式 I 的化合物、它们的制剂和它们在制备用作细胞抑制剂的治疗组合物中的用途。