2-amino-5-hydroxypyrimidine-4,6(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-amino-5-hydroxypyrimidine-4,6(1H,3H)-dione
• 英文别名: 2-amino-4,5,6-trihydroxypyrimidine；2-Amino-5,6-dihydroxypyrimidin-4(1H)-one；2-amino-4,5-dihydroxy-1H-pyrimidin-6-one
• 化学式: C₄H₅N₃O₃
• mdl: MFCD19211854
• 分子量: 143.102
• InChiKey: IUERSPKKRZJKJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl hydrogen sulfate 在 盐酸 作用下， 反应 0.25h， 生成 2-amino-5-hydroxypyrimidine-4,6(1H,3H)-dione
  参考文献：
  名称：

  Hurst, Derek T., Australian Journal of Chemistry, 1983, vol. 36, # 6, p. 1285 - 1289

  摘要：

  DOI：

文献信息

• The performance and degradation mechanism of sulfamethazine from wastewater using IFAS-MBR
  作者：Huanhuan Hou、Liang Duan、Beihai Zhou、Yuan Tian、Jian Wei、Feng Qian

  DOI：10.1016/j.cclet.2019.08.031

  日期：2020.2

  Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norankp-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
• HURST, D. T., AUSTRAL. J. CHEM., 1983, 36, N 6, 1285-1289
  作者：HURST, D. T.

  DOI：——

  日期：——
• Hurst, Derek T., Australian Journal of Chemistry, 1983, vol. 36, # 6, p. 1285 - 1289
  作者：Hurst, Derek T.

  DOI：——

  日期：——