2-(2-t-butylaminoethoxy)ethyl acetate | 863880-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-t-butylaminoethoxy)ethyl acetate
• 英文别名: t-BuNHCH2CH2OCH2CH2OAc；2-[2-(tert-butylamino)ethoxy]ethyl acetate
• CAS: 863880-61-9
• 化学式: C₁₀H₂₁NO₃
• 分子量: 203.282
• InChiKey: IFCWTENPVAHBJL-UHFFFAOYSA-N

物化性质

• 沸点：
  263.1±15.0 °C(Predicted)
• 密度：
  0.957±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-t-butylaminoethoxy)ethyl acetate 在 甲醇 、 sodium methylate 作用下， 反应 10.0h， 以70%的产率得到叔丁胺基乙氧基乙醇
  参考文献：
  名称：

  [EN] SYNTHESIS OF STERICALLY HINDERED SECONDARY AMINOETHER ALCOHOLS
  [FR] SYNTHESE D'ALCOOLS AMINOÉTHER SECONDAIRES A ENCOMBREMENT STERIQUE

  摘要：

  通过将有机羧酸、有机羧酸酰卤、酸酐或酮烯与烷基、烷基芳基或烷基卤代磺酸酯反应，制备严重立体阻碍的二级氨醚醇，产物为磺酸。然后将羧酸酐化合物与二氧六环反应，裂解二氧六环的环，产生一个裂解产物，该裂解产物然后与烷基胺进行胺化反应，并用碱水解，得到严重立体阻碍的二级氨醚醇。

  公开号：

  WO2005082835A1
• 作为产物：
  描述：

  2-acetoxyethyl-2'-tosyloxyethyl ether 、 叔丁胺 以 甲苯 为溶剂， 反应 3.0h， 以88%的产率得到2-(2-t-butylaminoethoxy)ethyl acetate
  参考文献：
  名称：

  [EN] SYNTHESIS OF STERICALLY HINDERED SECONDARY AMINOETHER ALCOHOLS
  [FR] SYNTHESE D'ALCOOLS AMINOÉTHER SECONDAIRES A ENCOMBREMENT STERIQUE

  摘要：

  通过将有机羧酸、有机羧酸酰卤、酸酐或酮烯与烷基、烷基芳基或烷基卤代磺酸酯反应，制备严重立体阻碍的二级氨醚醇，产物为磺酸。然后将羧酸酐化合物与二氧六环反应，裂解二氧六环的环，产生一个裂解产物，该裂解产物然后与烷基胺进行胺化反应，并用碱水解，得到严重立体阻碍的二级氨醚醇。

  公开号：

  WO2005082835A1

文献信息

• Synthesis of Sterically Hindered Secondary Aminoether Alcohols
  申请人：Siskin Michael

  公开号：US20070219400A1

  公开（公告）日：2007-09-20

  Severely sterically hindered secondary aminoether alcohols are prepared by reacting an organic carboxylic acid or alkali metal salt of an organic carboxylic acid with a sulfonyl halide, a sulfuryl halide, a mixed sulfuryl ester halide or a mixed sulfuryl amide halide to yield a sulfonic-carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane, yielding a cleavage product which cleavage product is then aminated with an alkylamine and hydrolyzed with base to yield the severely sterically hindered secondary aminoether alcohol.

  通过将有机羧酸或有机羧酸的碱金属盐与磺酰卤、亚磺酰卤、混合亚磺酰酯卤或混合亚磺酰酰胺卤反应，制备了严重受立体位阻的二级氨醚醇。得到磺酸羧酸酐化合物，然后与二噁烷反应以裂解二噁烷的环，产生一个裂解产物，然后用烷基胺进行胺化，再用碱水解，得到严重受立体位阻的二级氨醚醇。
• [EN] SYNTHESIS OF STERICALLY HINDERED SECONDARY AMINOETHER ALCOHOLS FROM ACID ANHYDRIDE AND/OR ACID HALIDE AND SULFUR TRIOXIDE<br/>[FR] SYNTHESE AMELIOREE D'ALCOOLS D'AMINOETHER SECONDAIRE A ENCOMBREMENT STERIQUE SEVERE A PARTIR D'ANHYDRIDES ACIDES ET/OU D'HALOGENURES ACIDES ET DE TRIOXYDES DE SOUFRE
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2005082837A1

  公开（公告）日：2005-09-09

  Severely sterically hindered secondary aminoether alcohols are prepared by reacting acid anhydrides or organic carboxylic acid halides with S03 to yield a sulfonic carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane yielding a cleavage product which is then aminated with an alkylamine and hydrolyzed with a base to yield the severely sterically hindered secondary aminoether alcohol.

  通过将酸酐或有机羧酸卤化物与S03反应，制备了严重受立体位阻的二级氨醚醇。生成磺酸羧酸酐化合物，然后与二氧六环反应裂解二氧六环的环，生成裂解产物，随后用烷基胺进行胺化反应，并用碱水解，得到严重受立体位阻的二级氨醚醇。
• [EN] SYNTHESIS OF SEVERELY STERICALLY HINDERED SECONDARY AMINOETHER ALCOHOLS FROM A KETENE AND/OR CARBOXYLIC ACID HALIDE AND/OR CARBOXYLIC ACID ANHYDRIDE<br/>[FR] SYNTHESE D'ALCOOLS D'AMINOETHER SECONDAIRE A ENCOMBREMENT STERIQUE SEVERE A PARTIR DE CETENES ET/OU D'HALOGENURES ACIDES CARBOXYLIQUES ET/OU D'ANHYDRIDES ACIDES CARBOXYLIQUES
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2005082836A1

  公开（公告）日：2005-09-09

  Severely sterically hindered secondary aminoether alcohols are prepared by a process comprising reacting a ketene with sulfuric acid to produce an anhydride which is then reacted with, to cleave the ring of, a dioxane to yield a cleavage product which is then aminated using an amine, followed by hydrolysis with a base to yield the desired severely sterically hindered secondary aminoether alcohol.

  严重有立体位阻的次级氨基醚醇是通过以下过程制备的：将酮与硫酸反应以产生酸酐，然后将酸酐与二氧六环反应，以裂解环，得到裂解产物，然后使用胺进行氨基化，接着使用碱水解，得到所需的严重有立体位阻的次级氨基醚醇。
• Synthesis of Sterically Hindered Secondary Aminoether Alcohols from Acid Anhydride and/or Acid Halide and Sulfur Trioxide
  申请人：Siskin Michael

  公开号：US20070260092A1

  公开（公告）日：2007-11-08

  Severely sterically hindered secondary aminoether alcohols are prepared by reacting acid anhydrides or organic carboxylic acid halides with SO 3 to yield a sulfonic carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane yielding a cleavage product which is then aminated with an alkylamine and hydrolyzed with a base to yield the severely sterically hindered secondary aminoether alcohol.

  严重空间位阻的次级氨基醚醇是通过将酸酐或有机羧酸卤化物与SO3反应制备而成，以产生磺酸羧酸酐化合物，然后与二噁烷反应裂解二噁烷环，得到一个裂解产物，然后用烷基胺进行氨基化，再用碱水解，最终得到严重空间位阻的次级氨基醚醇。
• Synthesis of sterically hindered secondary aminoether alcohols from acid anhydride and/or acid halide and sulfur trioxide
  申请人：ExxonMobil Research and Engineering Company

  公开号：US07351865B2

  公开（公告）日：2008-04-01

  Severely sterically hindered secondary aminoether alcohols are prepared by reacting acid anhydrides or organic carboxylic acid halides with SO3 to yield a sulfonic carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane yielding a cleavage product which is then aminated with an alkylamine and hydrolyzed with a base to yield the severely sterically hindered secondary aminoether alcohol.

  严重的立体阻碍次级氨基醚醇是通过将酸酐或有机羧酸卤化物与SO3反应制备的，以产生磺酸羧酸酐化合物，然后与二噁烷反应断开二噁烷环，生成断裂产物，然后用烷基胺进行氨化，再用碱水解，得到严重的立体阻碍次级氨基醚醇。