3-tert-butyl-2H-isoxazol-5-one | 92745-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-tert-butyl-2H-isoxazol-5-one
• 英文别名: 3-tert-Butyl-2H-isoxazol-5-on；3-t-butyl-5-isoxazolone；3-Tert-butyl-1,2-oxazol-5-ol；3-tert-butyl-2H-1,2-oxazol-5-one
• CAS: 92745-97-6
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: CBGJIFANNVKZNE-UHFFFAOYSA-N

物化性质

• 沸点：
  174.6±23.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  特戊酰基乙酸乙酯 在 盐酸 、 甲醇 、 羟胺 、 苯胺 作用下， 生成 3-tert-butyl-2H-isoxazol-5-one
  参考文献：
  名称：

  P REHOSPITAL A IRWAY M ANAGEMENT WITH THE L ARYNGEAL M ASK A IRWAY IN P OLYTRAUMATIZED P ATIENTS

  摘要：

  DOI：

  10.1080/10903120190939869

文献信息

• KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：US20170291917A1

  公开（公告）日：2017-10-12

  There are provided compounds of formula I, wherein T, A, Q, Z, G, R 4 , R 5a , R 5b and n have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了化合物I的公式，其中T、A、Q、Z、G、R4、R5a、R5b和n的含义如描述中所示，这些化合物具有抗炎活性（例如，通过抑制p38丝裂原活化蛋白激酶酶家族中的一个或多个成员；Syk激酶；以及酪氨酸激酶Src家族的成员之一）并且在治疗中有用，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• Process for the production of 3-amino-5-t-butylisoxazole
  申请人：Shionogi & Co., Ltd.

  公开号：US04256899A1

  公开（公告）日：1981-03-17

  3-Amino-5-t-butylisoxazole is prepared by reacting pivaloylacetonitrile with hydroxylamine in aqueous medium under basic conditions and treating the reaction products with an acid. The process is economical and industrial.

  3-氨基-5-t-丁基异噁唑是通过在碱性条件下在水性介质中将假丙酰基乙腈与羟胺反应，并用酸处理反应产物制备的。这个过程经济实用，适用于工业生产。
• Visible image dyes for positive-acting no-process printing plates
  申请人：Minnesota Mining and Manufacturing Company

  公开号：US05665522A1

  公开（公告）日：1997-09-09

  Positive-acting no-process printing plates are disclosed in which a stable visual or print-out image is obtained upon exposure of the plate to actinic radiation. The visual image is obtained by incorporation into the photosensitive layer, a dye which is irreversibly bleached upon exposure of the printing plate. For example, an acid which is generated upon exposure of a photopolymer to radiation may be used to bleach a dye of this invention. The visual or print-out images produced are useful in the production cycle and are stable to basic environments that may be encountered in the production setting.

  本发明揭示了一种正作用无工艺印刷版，其中在将版曝光于光敏辐射下后得到稳定的视觉或印刷图像。通过将一种染料不可逆地漂白到印刷版的光敏层中，可以获得视觉图像。例如，通过曝光光敏聚合物产生的酸可以用来漂白本发明中的染料。所产生的视觉或印刷图像在生产周期中非常有用，并且对于在生产环境中可能遇到的碱性环境是稳定的。
• Process for preparing 3-amino-5-t-butylisoxazole
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0010262A1

  公开（公告）日：1980-04-30

  The invention relates to a process for preparing 3-amino-5-t-butylisoxazole by reacting pivaloylacetonitrile whith hydroxylamine in an aqueous medium under basic conditions and treating the reaction products with an acid.

  本发明涉及一种制备 3-氨基-5-t-丁基异噁唑的工艺，其方法是在碱性条件下，在水介质中使新戊酰乙腈与羟胺反应，并用酸处理反应产物。
• Kinase inhibitors
  申请人：Topivert Pharma Limited

  公开号：US10442828B2

  公开（公告）日：2019-10-15

  There are provided compounds of: wherein T, A, Q, Z, R4, R5a, R5b, n, r, Het1 and Rx have meanings given in the description, which compounds are useful in synthesizing compounds that have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供的化合物包括 其中 T、A、Q、Z、R4、R5a、R5b、n、r、Het1 和 Rx 具有描述中给出的含义，这些化合物可用于合成具有抗炎活性（例如、p38 丝裂原活化蛋白激酶家族；Syk 激酶；和酪氨酸激酶 Src 家族成员）中的一个或多个成员的抑制作用，可用于治疗，包括药物组合，特别是治疗炎症性疾病，包括肺部、眼部和肠道的炎症性疾病。