5,7-Dihydroxy-6-methoxy-2-phenyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one | 1021312-36-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7-Dihydroxy-6-methoxy-2-phenyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one
• CAS: 1021312-36-6
• 化学式: C₂₁H₂₁NO₅
• 分子量: 367.401
• InChiKey: HLCLPIQUDJBLCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 聚合甲醛 、 千层纸素A 以 异丙醇 为溶剂， 生成 5,7-Dihydroxy-6-methoxy-2-phenyl-8-(pyrrolidin-1-ylmethyl)chromen-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors

  摘要：

  A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A). (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.055

文献信息

• Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors
  作者：T. Hari Babu、V. Rama Subba Rao、Ashok K. Tiwari、K. Suresh Babu、P.V. Srinivas、Amtul Z. Ali、J. Madhusudana Rao

  DOI：10.1016/j.bmcl.2008.01.055

  日期：2008.3

  A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A). (c) 2008 Elsevier Ltd. All rights reserved.