3-acetyl-9,10-dimethoxyphenanthrene | 897649-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-acetyl-9,10-dimethoxyphenanthrene
• 英文别名: 1-(9,10-Dimethoxyphenanthren-3-yl)ethanone
• CAS: 897649-08-0
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: BUNVAXIAOSTHHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-acetyl-9,10-dimethoxyphenanthrene 在 4-二甲氨基吡啶 、 sodium dithionite 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 乙酸乙酯 、 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 30.67h， 生成 4,7,7-trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid 1,2,5,7-tetramethoxy-dibenzo[c,g]phenanthren-10-yl ester
  参考文献：
  名称：

  A [5]HELOL Analogue That Senses Remote Chirality in Alcohols, Phenols, Amines, and Carboxylic Acids

  摘要：

  A route is developed to a structural analogue of [5]HELOL, a previously reported helically grooved sensor of remote chirality. It gives the material enantiomerically pure and in multigram quantities. The enantiomers of alcohols, phenols, amines, and carboxylic acids, even when their centers of chirality are remote from any functional groups, can be differentiated by P-31 NMR spectroscopic analyses of their reaction products with the chlorophosphite of this material.

  DOI：

  10.1021/jo0512913
• 作为产物：
  描述：

  9,10-dimethoxyphenanthrene 、 乙酰氯 在 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 以28.2 g的产率得到3-acetyl-9,10-dimethoxyphenanthrene
  参考文献：
  名称：

  A [5]HELOL Analogue That Senses Remote Chirality in Alcohols, Phenols, Amines, and Carboxylic Acids

  摘要：

  A route is developed to a structural analogue of [5]HELOL, a previously reported helically grooved sensor of remote chirality. It gives the material enantiomerically pure and in multigram quantities. The enantiomers of alcohols, phenols, amines, and carboxylic acids, even when their centers of chirality are remote from any functional groups, can be differentiated by P-31 NMR spectroscopic analyses of their reaction products with the chlorophosphite of this material.

  DOI：

  10.1021/jo0512913

文献信息

• Continuous flow photocyclization of stilbenes – scalable synthesis of functionalized phenanthrenes and helicenes
  作者：Quentin Lefebvre、Marc Jentsch、Magnus Rueping

  DOI：10.3762/bjoc.9.221

  日期：——

  A continuous flow oxidative photocyclization of stilbene derivatives has been developed which allows the scalable synthesis of backbone functionalized phenanthrenes and helicenes of various sizes in good yields.

  已经开发了二苯乙烯衍生物的连续流动氧化光环化，它允许以良好的产率大规模合成各种尺寸的骨架官能化菲和螺旋。
• Substituted phenanthrene diketo acids and uses therefor
  申请人：Buolamwini John K.

  公开号：US20090088444A1

  公开（公告）日：2009-04-02

  Provided herein are substituted phenanthrene diketo acid compounds. These compounds comprise the diketo acid moiety on one of carbons C1-C4 and C9 in the phenanthrene ring and at least one further substitutent on the other ring carbons. Also provided are methods of inhibiting an activity of a human immunodeficiency virus (HIV) integrase protein and treating an HIV infection in a subject using the substituted phenanthrene diketo acid compounds.
• A [5]HELOL Analogue That Senses Remote Chirality in Alcohols, Phenols, Amines, and Carboxylic Acids
  作者：David Zhigang Wang、Thomas J. Katz

  DOI：10.1021/jo0512913

  日期：2005.10.1

  A route is developed to a structural analogue of [5]HELOL, a previously reported helically grooved sensor of remote chirality. It gives the material enantiomerically pure and in multigram quantities. The enantiomers of alcohols, phenols, amines, and carboxylic acids, even when their centers of chirality are remote from any functional groups, can be differentiated by P-31 NMR spectroscopic analyses of their reaction products with the chlorophosphite of this material.