3-(tert-butyldimethylsilyloxymethyl)-2-nitrobenzoic acid | 936943-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(tert-butyldimethylsilyloxymethyl)-2-nitrobenzoic acid
• 英文别名: 3-[[tert-butyl(dimethyl)silyl]oxymethyl]-2-nitrobenzoic acid
• CAS: 936943-03-2
• 化学式: C₁₄H₂₁NO₅Si
• 分子量: 311.41
• InChiKey: GZBGAZVZEHEUII-UHFFFAOYSA-N

物化性质

• 沸点：
  398.4±37.0 °C(Predicted)
• 密度：
  1.147±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(tert-butyldimethylsilyloxymethyl)-2-nitrobenzoic acid 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.25h， 生成 3-((3-azidopropyl)carbamoyl)-2-nitrobenzyl (4-nitrophenyl) carbonate
  参考文献：
  名称：

  Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP

  摘要：

  Graft through ring-opening metathesis polymerization (ROMP) using ruthenium N heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control Here we report the first bivalent-brush polymers, these materials were prepared by graft through ROMP of drug-loaded poly(ethylene glycol) (PEG) based macromonomers (MMs) Anticancer drugs doxorubicin (DOX) and camptothecin (CT) were attached to a norbornene alkyne-PEG MM via a photocleavable linker ROMP of either or both drug loaded MMs generated brush homo and copolymers with low polydispersities and defined molecular weights Release of free DOX and CT from these materials was initiated by exposure to 365 nm light All of the CT and DOX polymers were at least 10 fold more toxic to human cancer cells after photoinitiated drug release while a copolymer carrying both CT and DOX displayed 30-fold increased toxicity upon irradiation Graft through ROMP of drug loaded macromonomers provides a general method for the systematic study of structure function relationships for stimuli responsive polymers in biological systems

  DOI：

  10.1021/ma1021506
• 作为产物：
  描述：

  2-nitro-3-(tert-butyldimethylsilyloxymethyl)-hydroxymethylbenzene 、 三氯异氰尿酸 、 异丙醇 在 氟氯氰菊酯 、 碳酸氢钠 、 sodium bromide 作用下， 以 sodium carbonate 、 丙酮 为溶剂， 以56%的产率得到3-(tert-butyldimethylsilyloxymethyl)-2-nitrobenzoic acid
  参考文献：
  名称：

  MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS

  摘要：

  本发明涉及一种从任何单体官能团制备可降解模型网络的方法。它基于使用原子转移自由基聚合和CLICK化学来形成所需的产物。

  公开号：

  US20090259016A1

文献信息

• Method of preparing a star polymer macromonomer
  申请人：Johnson Jeremiah

  公开号：US08378041B2

  公开（公告）日：2013-02-19

  The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.

  本发明涉及使用任何单体官能团和任何降解方法制备可降解模型网络的方法。它基于使用原子转移自由基聚合CLICK化学和具有端部卤素基团的四官能基引发剂来形成所需的产物。
• Macromonomers for preparation of degradable polymers and model networks
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US09200097B2

  公开（公告）日：2015-12-01

  The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.

  本发明涉及制备可降解模型网络的方法，该方法可以使用任何单体功能和任何降解方法。该方法基于使用原子转移自由基聚合和点击化学来形成所需的产品。
• Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP
  作者：Jeremiah A. Johnson、Ying Y. Lu、Alan O. Burts、Yan Xia、Alec C. Durrell、David A. Tirrell、Robert H. Grubbs

  DOI：10.1021/ma1021506

  日期：2010.12.28

  Graft through ring-opening metathesis polymerization (ROMP) using ruthenium N heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control Here we report the first bivalent-brush polymers, these materials were prepared by graft through ROMP of drug-loaded poly(ethylene glycol) (PEG) based macromonomers (MMs) Anticancer drugs doxorubicin (DOX) and camptothecin (CT) were attached to a norbornene alkyne-PEG MM via a photocleavable linker ROMP of either or both drug loaded MMs generated brush homo and copolymers with low polydispersities and defined molecular weights Release of free DOX and CT from these materials was initiated by exposure to 365 nm light All of the CT and DOX polymers were at least 10 fold more toxic to human cancer cells after photoinitiated drug release while a copolymer carrying both CT and DOX displayed 30-fold increased toxicity upon irradiation Graft through ROMP of drug loaded macromonomers provides a general method for the systematic study of structure function relationships for stimuli responsive polymers in biological systems
• MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS
  申请人：Johnson Jeremiah

  公开号：US20090259016A1

  公开（公告）日：2009-10-15

  The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.

  本发明涉及一种从任何单体官能团制备可降解模型网络的方法。它基于使用原子转移自由基聚合和CLICK化学来形成所需的产物。